piplartine has been researched along with Osteolysis* in 1 studies
1 other study(ies) available for piplartine and Osteolysis
| Article | Year |
|---|---|
Piperlongumine Inhibits Titanium Particles-Induced Osteolysis, Osteoclast Formation, and RANKL-Induced Signaling Pathways.
Wear particle-induced aseptic loosening is the most common complication of total joint arthroplasty (TJA). Excessive osteoclast formation and bone resorptive activation have been considered to be responsible for extensive bone destruction and prosthesis failure. Therefore, identification of anti-osteoclastogenesis agents is a potential therapy strategy for the treatment of aseptic loosening and other osteoclast-related osteolysis diseases. In the present study, we reported, for the first time, that piperlongumine (PL), a key alkaloid compound from Topics: Animals; Bone Resorption; Dioxolanes; Mice; Mice, Inbred C57BL; NF-kappa B; Osteoclasts; Osteogenesis; Osteolysis; RANK Ligand; Signal Transduction; Titanium | 2022 |