piplartine has been researched along with Brain-Ischemia* in 1 studies
1 other study(ies) available for piplartine and Brain-Ischemia
Article | Year |
---|---|
Design and Green Synthesis of Piperlongumine Analogs and Their Antioxidant Activity against Cerebral Ischemia-Reperfusion Injury.
The supplementation of exogenous antioxidants to scavenge excessive reactive oxygen species (ROS) is an effective treatment for cerebral ischemia-reperfusion injury (CIRI) in stroke. Piperlongumine (PL), a natural alkaloid, has a great potential as a neuroprotective agent, but it also has obvious toxicity. Moreover, its neuroprotective effects remain to be improved. In this study, we designed a series of novel PL analogs by hybridizing the screened low-toxicity diketene skeleton with antioxidant effect and the 3,4,5-trimethoxyphenyl group, which may increase the antioxidant activity of PL. The intermediate was synthesized by a novel green synthesis method, and 34 compounds were obtained. The compounds without obvious cytotoxicity have remarkable antioxidant effects, especially compared with diketene skeletons and PL. The cytoprotection of the active compound decreased significantly by reduction of the carbon-carbon double bonds of the Michael acceptor in the diketene skeleton. More importantly, further study revealed that compound Topics: Animals; Antioxidants; Astrocytes; Brain Ischemia; Cell Survival; Dioxolanes; Drug Design; Green Chemistry Technology; Male; Oxidative Stress; PC12 Cells; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Reperfusion Injury | 2019 |