piperine and Stomach-Ulcer

Topics: Animals; Ethanol; Gastric Mucosa; Kelch-Like ECH-Associated Protein 1; NF-E2-Related Factor 2; Oxidative Stress; Rats; RNA, Messenger; Stomach Ulcer; Superoxide Dismutase

Nineteen novel piperine based triazoles have been synthesized using click chemistry approach and were tested for in vivo anti-inflammatory activity. The most active compounds were evaluated for in vitro TNF-α expression. Compounds 3g and 3f were found to show significant in vivo inhibition of inflammation, 80.40% and 76.71%, respectively after 5 h in comparison to piperine (54.72%) and the standard drug indomethacin (77.02%) without causing any damage to the stomach. Compounds 3g and 3f suppressed TNF-α level by 73.73% and 70.64%, respectively and protein expression of COX-2, NF-κB and TNF-α more than indomethacin. Moreover, the compound 3g was found to show significant analgesic activity of 54.09% which was comparable with the indomethacin (57.43%).

Topics: Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti-Ulcer Agents; Cell Line; Cell Survival; Click Chemistry; Dose-Response Relationship, Drug; Drug Design; Fatty Acids, Unsaturated; Mice; Models, Molecular; Molecular Structure; Piper nigrum; Rats; Rats, Wistar; Stomach Ulcer; Structure-Activity Relationship; Triazoles

To study the effects of piperine (Pip) on several experimental gastric ulcers in rats and mice.. The gastric mucosa damage was induced by stress, indometacin, HCl, and pyloric ligation in rats or mice. The number of gastric ulcers, the volume and acidity of gastric juices, and pepsin A activity were detected.. Pip 25, 50, 100 mg/kg ig protected animals from gastric ulceration in a dose-dependent manner. The inhibitory rates were 16.9%, 36.0%, and 48.3% in stress ulcers; 4.4%, 51.1%, and 64.4% in indometacin ulcers; 19.2%, 41.5%, and 59.6% in HCl ulcers; 4.8%, 11.9%, and 26.2% in pyloric ligation ulcers, respectively; Pip inhibited the volume of gastric juice, gastric acidity, and pepsin A activity.. Pip has the protective effects against gastric ulceration.

Topics: Alkaloids; Animals; Anti-Ulcer Agents; Benzodioxoles; Dose-Response Relationship, Drug; Female; Gastric Acid; Gastric Juice; Gastric Mucosa; Male; Mice; Piperidines; Polyunsaturated Alkamides; Rats; Stomach Ulcer; Tyrosine

Topics: Alkaloids; Animals; Anti-Ulcer Agents; Benzodioxoles; Capsaicin; Diterpenes; Ethanol; Female; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Inbred Strains; Stomach Ulcer