piperidines and Vulvar-Neoplasms

Mucosal melanoma is rare and accounts for 1.3-1.4% of all melanomas. Kit mutations are found in approximately 15-20% of mucosal melanomas. Immunotherapy with anti cytotoxic T-lymphocyte associated protein 4 and antiprogrammed cell death protein 1 have reported low clinical efficacy in this melanoma subtype. Studies with Kit inhibitor Imatinib showed response rates ranging from 20 to 30%. We present the case of a patient with a c-kit mutated metastatic melanoma who developed autoimmune vitiligo during treatment with oral tyrosine kinase inhibitor Masitinib.

Topics: Antineoplastic Agents; Benzamides; Female; Humans; Lymphatic Metastasis; Melanoma; Middle Aged; Piperidines; Prognosis; Proto-Oncogene Proteins c-kit; Pyridines; Thiazoles; Vitiligo; Vulvar Neoplasms