piperidines and Torticollis

Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Piperidines; Torticollis

We reported a patient with probable dementia with Lewy bodies (DLB) showing cervical dystonia during treatment with donepezil. A 78-year-old female had been treated with donepezil 5 mg/day for 18 months. The patient admitted to our hospital because of severe antecollis. Antecollis disappeard three weeks after discontinuation of donepezil. Five months later the patient received donepezil 3-5 mg/day for disease progression. The patient showed laterocollis again after a month-treatment with donepezil. Physical examination and labolatory tests were nomal. Magnetic resonance imaging of the neck showed no abnormal finding, but electromyography revealed dystonic changes in the neck muscles. Three weeks after discontinuation of donepezil, laterocollis disappeared. These findings suggest that treatment with donepezil induced cervical dystona in a patient with DLB.

Topics: Aged; Donepezil; Electromyography; Female; Humans; Indans; Lewy Body Disease; Piperidines; Torticollis

Striatal dysfunction is thought to underlie many dystonias. We used [(123)I]iodobenzovesamicol single-photon emission computed tomography imaging to determine the density of cholinergic terminals in the striatum and other brain regions in 13 subjects with idiopathic cervical dystonia. Striatal [(131)I]iodobenzovesamicol binding was reduced. These results support a role for striatal dysfunction in idiopathic dystonias and suggest diminished striatal cholinergic interneuron density in cervical dystonia.

Topics: Adult; Aged; Carrier Proteins; Cholinergic Fibers; Corpus Striatum; Female; Humans; Iodine Radioisotopes; Male; Membrane Transport Proteins; Middle Aged; Piperidines; Tetrahydronaphthalenes; Tomography, Emission-Computed, Single-Photon; Torticollis; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins

Topics: Cisapride; Esophagitis; Female; Humans; Infant; Piperidines; Torticollis; Trimebutine

To clarify clinical roles of sigma receptor binding affinity of neuroleptics, neck dystonia induced by microinjection of sigma receptor ligands and neuroleptics into rat red nucleus was investigated. DTG and (+)-3-PPP, putative sigma receptor agonists, induced neck dystonia in dose-dependent and reversible manner. Haloperidol and perphenazine induced dystonia in the same way as sigma receptor agonists, whereas zotepine and (-)-sulpiride did not. The rank order of potency in induction of dystonia and sigma receptor affinity of these compounds showed positive correlation. Although BMY-14802 has a high affinity for sigma receptors, it never produced dystonia by itself. On the other hand, combined injection of BMY-14802 with DTG attenuated DTG-induced dystonia. Therefore, it is suggested that typical neuroleptics such as haloperidol act agonistic and atypical neuroleptics such as BMY-14802 act antagonistic at rubral sigma receptors in the induction of neck dystonia.

Topics: Animals; Antipsychotic Agents; Dibenzothiepins; Dopamine Antagonists; Dopamine D2 Receptor Antagonists; Dystonia; Guanidines; Haloperidol; Male; Microinjections; Nerve Tissue Proteins; Perphenazine; Piperidines; Pyrimidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine D2; Receptors, sigma; Red Nucleus; Sulpiride; Torticollis

Topics: Adult; Benzydamine; Contusions; Dibucaine; Drug Combinations; Female; Humans; Hyaluronoglucosaminidase; Joint Diseases; Male; Middle Aged; Periarthritis; Piperidines; Pyrazoles; Rheumatic Diseases; Sprains and Strains; Torticollis

Topics: Aminopyrine; Dipyrone; Drug Combinations; Drug Evaluation; Drug Synergism; Humans; Neuritis; Piperidines; Torticollis