piperidines and Tongue-Neoplasms

Endothelin plays important roles in various physiological functions including vascular constriction. Recent studies reported that the endothelin receptors ETA and ETB are highly expressed in lung and skin tumor tissues. In contrast, there are few reports on endothelin signalling in the proliferation of head and neck cancer. We found that both ETA and ETB endothelin receptors were overexpressed in tumor cells of tongue cancer samples by immunohistochemistry. ETA and ETB were expressed in cultured lingual and esophageal squamous cell carcinoma (SCCs) cell lines. When both cultured cell lines were treated with an ETA selective antagonist (BQ123) or an ETB selective antagonist (BQ788), inhibition of cell growth was observed. Similar results were observed when SCCs were treated with specific siRNA for the suppression of ETA or ETB. Furthermore, inhibition of the mitogen-activated protein (MAP) kinase pathway by the treatments with ET receptor antagonists and siRNA was also observed. These results indicate that endothelin signalling may, in part, play important roles in cell growth in SCCs through the MAP kinase pathway.

Topics: Adult; Aged; Aged, 80 and over; Cell Growth Processes; Cell Line, Tumor; Cisplatin; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelins; Female; Humans; Immunohistochemistry; Male; MAP Kinase Signaling System; Middle Aged; Neoplasms, Squamous Cell; Oligopeptides; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; RNA Interference; RNA, Small Interfering; Signal Transduction; Tongue Neoplasms

Topics: Carcinoma; Chemotherapy, Adjuvant; Drug Eruptions; Histamine H2 Antagonists; Humans; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Piperidines; Psoriasis; Radiodermatitis; Radiotherapy, Adjuvant; Tongue Neoplasms

We present a unique, practical, and safe approach to the clinical management of a young male with a large tongue hemangioma who presented for serial surgical treatment of the lesion. Laser ablation was undertaken in the operating room under topical anesthesia with remifentanil analgosedation without the use of supplemental oxygen. Significant involution of the hemangioma was achieved without complication while the patient was awake, cooperative, and able to protect his airway. The application of remifentanil infusion for analgosedation during airway surgery is described. The utility of pharmacokinetic modeling in these applications is discussed along with the use of non-invasive respiratory inductance plethysmography to monitor ventilation during opioid sedation. The concept of analgosedation for airway surgery is introduced and relative risk versus benefit considerations of the approach in comparison to general anesthesia are discussed. This approach can be conceived of as an ORL endoscopy suite model for limited airway procedures.

Topics: Administration, Topical; Conscious Sedation; Hemangioma; Humans; Hypnotics and Sedatives; Laser Therapy; Male; Oral Surgical Procedures; Piperidines; Plethysmography; Remifentanil; Tongue Neoplasms; Young Adult

Topics: Aged; Analgesics, Opioid; Humans; Male; Myasthenia Gravis; Piperidines; Remifentanil; Tongue Neoplasms

Three chlorinated nitrosopiperidines, 3-chloro-, 4-chloro-, and 3,4-dichloronitrosopiperidine, were administered to groups of 20 male Fischer 344 rats at a concentration of 0.17 mM in drinking water. Treatment with the monochloro compounds lasted for 30 weeks, while treatment with the dichloro compound lasted for 21 weeks. Almost all of the animals died with esophageal tumors. There was also a significant incidence of tumors of the forestomach and tongue in the rats treated with the monochloro compounds. Using the rate of death of the animals with tumors as an index, the relative potency of the three compounds increases from 3-chloro- to 4-chloro- to 3,4-dichloronitrosopiperidine.

Topics: Animals; Carcinogens; Carcinoma; Drinking; Esophageal Neoplasms; Male; Nitrosamines; Papilloma; Piperidines; Rats; Stomach Neoplasms; Time Factors; Tongue Neoplasms

The carcinogenic potencies of 3,4-dichloro- and 3,4-dibromonitrosopiperdine were compared with that of nitrosopiperidine by feeding to groups of 15 male rats in drinking water. A treatment of 15 weeks with a total of 0.5 mmole of the dichloro compound led to death of all animals before 24 weeks with tumors of the tongue, pharynx, esophagus, nonglandular stomach, nasal turbinates, trachea, bronchi, and bronchioles. Treatment of 27 weeks with the dibromo compound, a total of 1.0 mmole, caused death of all the animals by 41 weeks, with the same types of tumors. One-half of the rats treated with an almost 3-fold higher daily dose of nitrosopiperidine, 3.9 mmoles total, were alive at 40 weeks, and all were not dead until 55 weeks. Most of these animals died with tumors of the tongue, pharynx, esophagus, and nonglandular stomach and with squamous cell tumors and olfactory carcinomas of the nasal cavity, but there were no tumors of the respiratory tree. Substitution of chlorine or bromine in nitrosopiperidine greatly increased the carcinogenicity of the compound.

Topics: Animals; Carcinoma, Squamous Cell; Esophageal Neoplasms; Male; Nasopharyngeal Neoplasms; Neoplasms, Experimental; Nitrosamines; Pharyngeal Neoplasms; Piperidines; Rats; Stomach Neoplasms; Tongue Neoplasms

Topics: Amino Alcohols; Animals; Carcinogens; Carcinoma, Squamous Cell; Esophageal Neoplasms; Esters; Ethylamines; Ethylenediamines; Gastrointestinal Neoplasms; Neoplasms, Experimental; Nitrosamines; Nitroso Compounds; Papilloma; Piperazines; Piperidines; Precancerous Conditions; Rats; Sarcosine; Stomach Neoplasms; Time Factors; Tongue Neoplasms; Urethane