piperidines and Sinoatrial-Block

piperidines has been researched along with Sinoatrial-Block* in 3 studies

Other Studies

3 other study(ies) available for piperidines and Sinoatrial-Block

ArticleYear
[General anesthesia with remifentanil for a patient having sinoatrial block and constrictive pulmonary disorder].
    Masui. The Japanese journal of anesthesiology, 2008, Volume: 57, Issue:8

    There is little report describing the effect of remifentanil on cardiac conduction system. We present a successful anesthetic management with remifentanil in a patient with sick sinus syndrome. A 66-year-old woman (31-kg, 121-cm) having sinoatrial (SA) block was diagnosed as having hepatic cell carcinoma, and radiofrequency ablation (RFA) was scheduled. She was also suffering from kyphosis due to the past history of tuberculous spondylitis. Preoperative examination of her respiratory function indicated a severe constrictive pulmonary disorder. Anesthesia was induced with propofol (30 mg), and maintained with sevoflurane (1-2%) and oxygen/air in combination with remifentanil (0.5 microg x kg(-1) x min(-1)). Temporary pacemaker was prepared during anesthesia. Neither remifentanil nor sevoflurane deteriorated SA block and her heart rate was well controlled. Respiratory dysfunction was not seen in the postoperative course. Our case suggests that remifentanil may be a suitable analgesic for patients with cardiac conduction abnormalities.

    Topics: Aged; Anesthesia, General; Anesthetics, Intravenous; Catheter Ablation; Constriction, Pathologic; Female; Humans; Kyphosis; Liver Neoplasms; Lung Diseases; Piperidines; Remifentanil; Sinoatrial Block

2008
Atrio-sinus interaction demonstrated by blockade of the rapid delayed rectifier current.
    Circulation, 2002, Feb-19, Volume: 105, Issue:7

    Proper pacemaking of the heart requires a specific organization of the sinoatrial (SA) node. The SA node drives the surrounding atrium but needs to be protected from its hyperpolarizing influence, which tends to suppress pacemaker activity. It has been suggested that the hyperpolarizing atrial influence is minimal at the site of the central nodal area.. Atrio-sinus interaction was assessed by specific depolarization of the SA node by blocking the HERG-encoded rapid delayed rectifier current (I(K,r)) with the drug E-4031. In the SA node, E-4031 (1 micromol/L) changed action potential configuration drastically but never resulted in pacemaker arrest. In the atrium, E-4031 did not affect the membrane resting potential, thereby leaving the normal hyperpolarizing load on the SA node intact. When the SA node was sectioned into strips and subsequently separated from the atrium, spontaneous electrical activity of the strip containing the primary pacemaker ceased on I(K,r) blockade. When not separated from the atrium, I(K,r) blockade never resulted in pacemaker arrest. A similar effective atrio-sinus interaction was demonstrated in computer simulations.. Our results demonstrate that the atrium provides an effective hyperpolarizing load on the central SA nodal area and is at least one of the controlling mechanisms for normal pacemaking function. The present study can be of help in understanding why patients with long-QT2 syndrome secondary to a mutation in HERG do not show sinus arrest.

    Topics: Action Potentials; Animals; Anti-Arrhythmia Agents; Biological Clocks; Cation Transport Proteins; Computer Simulation; Electrophysiologic Techniques, Cardiac; Ether-A-Go-Go Potassium Channels; Heart Atria; Heart Conduction System; In Vitro Techniques; Long QT Syndrome; Membrane Potentials; Models, Cardiovascular; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rabbits; Sinoatrial Block; Sinoatrial Node

2002
Electrophysiological effects of lorcainide in sinoatrial disease and in Wolff-Parkinson-White syndrome.
    European heart journal, 1982, Volume: 3, Issue:1

    Topics: Adult; Aged; Anti-Arrhythmia Agents; Benzeneacetamides; Cardiac Pacing, Artificial; Female; Heart Block; Heart Conduction System; Heart Rate; Humans; Male; Middle Aged; Piperidines; Sinoatrial Block; Sinoatrial Node; Time Factors; Wolff-Parkinson-White Syndrome

1982