piperidines and Respiratory-Tract-Neoplasms

Nitrosopiperidine (NP) was found in Syrian hamsters quantitatively in the maternal blood for more than 8 h after subcutaneous injection, whereas it disappeared from placenta, fetus and amniotic fluid within the same time period. For N6MI, only traces were seen after 2 h in the same tissues. The long-term transplacental effect of a single dose of NP was weak, as demonstrated by a low respiratory tract tumor incidence (P-generation: 54%, F1- generation: 4%). Some tumors occurring in the digestive tract of exposed young were not found in their mothers and not commonly observed in controls. These tumors were considered a borderline transplacental effect. Tumors of other sites (i.e., the urogenital and genital tracts, reticuloendothelial system, endocrine organs and other tissues) corresponded in incidences to the overall fluctuations observed in this hamster colony.

Topics: Animals; Cricetinae; Female; Gastrointestinal Neoplasms; Maternal-Fetal Exchange; Mesocricetus; Neoplasms, Experimental; Nitrosamines; Piperidines; Placenta; Pregnancy; Respiratory Tract Neoplasms; Urogenital Neoplasms

Subcutaneous treatment of European hamsters with aliphatic (diethyl-, diisopropanol-,dibutylnitrosamine) and cyclic nitroso compounds (nitrosopiperidine, morpholine, and heptamethyleneimine) led to the development of respiratory tract tumors. Most of the neoplasms were seen in the nasal cavity and lungs, although tumors were also found in the larynx and trachea. Histologically, the tumors were diagnosed as papillary polyps, papillomas, adenomas, adenocarcinomas, squamous cell carcinomas and mixed carcinomas. The length and weight of this species permit the performance of routine diagnostic methods such as radiography, bronchography and bronchoscopy. All such methods help towards a particularly early diagnosis of benign and malignant lesions.

Topics: Adenocarcinoma; Animals; Azocines; Carcinoma, Squamous Cell; Cricetinae; Diethylnitrosamine; Lung Neoplasms; Morpholines; Nitrosamines; Piperidines; Respiratory Tract Neoplasms

A total of 320 Chinese hamsters (Cricetulus griseus) (CH) were subcutaneously (s.c.) treated with 1/5, 1/10, or 1/20 LD50 of N-nitrosomorpholine (NM) or N-nitrosopiperidine (NP). In the CH, NM and NP both produced up to a 100% rate of papillomas of the cheek pouch, tongue, pharynx, esophagus and forestomach. Occasionally squamous cell carcinomas also developed in these organs. A high rate of hepatomas was realized by NP.

Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Esophageal Neoplasms; Female; Liver Neoplasms; Male; Morpholines; Mouth Neoplasms; Neoplasms, Experimental; Nitrosamines; Nitroso Compounds; Nose Neoplasms; Papilloma; Pharyngeal Neoplasms; Piperidines; Respiratory Tract Neoplasms; Stomach Neoplasms

N'-Nitrosonornicotine (NNN) and N'-nitrosoanabasine (NAB) were synthesized and administered in drinking water to male Fischer rats for 30 weeks (total dose, 630 mg). 1,4-Dinitrosopiperazine (DNPI) served as the positive control. By 11 months, all surviving rats given NNN developed esophageal tumors (12/20); 1 had a pharyngeal tumor and 3 had invasive carcinomas originating in the nasal cavity. During the same time, only 1 of 20 rats given NAB developed esophageal tumors. Compared to the strong esophageal carcinogen DNPI, NNN was a moderately active and NAB a weak carcinogen. NNN (0.3-90 parts per million) in chewing tobacco was related to the observation that cancer of the oral cavity and esophagus in man was correlated with the chewing of tobacco.

Topics: Anabasine; Carcinogens; Gastrointestinal Neoplasms; Neoplasms, Experimental; Nicotiana; Nicotine; Nitroso Compounds; Piperazines; Piperidines; Plants, Toxic; Respiratory Tract Neoplasms; Smoking; Tobacco, Smokeless

Topics: Animals; Bronchial Neoplasms; Cricetinae; Epithelial Cells; Epithelium; Female; Laryngeal Neoplasms; Lethal Dose 50; Male; Microscopy, Electron, Scanning; Morpholines; Neoplasms, Experimental; Nitroso Compounds; Nose Neoplasms; Piperidines; Polyps; Respiratory Tract Neoplasms; Trachea; Tracheal Neoplasms

Topics: Animals; Carcinogens; Carcinoma, Squamous Cell; Cricetinae; Female; Gastrointestinal Neoplasms; Lung Neoplasms; Male; Morpholines; Mouth Neoplasms; Neoplasms, Experimental; Neoplasms, Multiple Primary; Nitrosamines; Nose Neoplasms; Piperidines; Respiratory Tract Neoplasms