piperidines and Nelson-Syndrome

piperidines has been researched along with Nelson-Syndrome* in 1 studies

Trials

1 trial(s) available for piperidines and Nelson-Syndrome

Article	Year
Effect of an oral serotonin antagonist, ketanserin, on plasma ACTH concentrations in Nelson's syndrome. British medical journal (Clinical research ed.), 1984, Sep-29, Volume: 289, Issue:6448 A study was performed to see whether ketanserin, a serotonin antagonist, would reduce the raised concentrations of adrenocorticotrophic hormone (ACTH) in patients with Nelson's syndrome. Six patients who had undergone bilateral adrenalectomy for Cushing's disease and who had Nelson's syndrome were given ketanserin 40 mg twice daily and placebo, for at least two months each, in a double blind crossover study. Ketanserin had no effect on ACTH concentrations. In healthy people serotonin seems to have a stimulatory role in the regulation of ACTH secretion, and the effect of ketanserin in reducing the ACTH response to hypoglycaemia suggested that it might prove useful in Nelson's syndrome. These results show that it is not indicated in these patients. Topics: Adrenocorticotropic Hormone; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ketanserin; Male; Middle Aged; Nelson Syndrome; Piperidines; Pituitary Neoplasms; Serotonin Antagonists	1984

Article

Year

Effect of an oral serotonin antagonist, ketanserin, on plasma ACTH concentrations in Nelson's syndrome.

British medical journal (Clinical research ed.), 1984, Sep-29, Volume: 289, Issue:6448

A study was performed to see whether ketanserin, a serotonin antagonist, would reduce the raised concentrations of adrenocorticotrophic hormone (ACTH) in patients with Nelson's syndrome. Six patients who had undergone bilateral adrenalectomy for Cushing's disease and who had Nelson's syndrome were given ketanserin 40 mg twice daily and placebo, for at least two months each, in a double blind crossover study. Ketanserin had no effect on ACTH concentrations. In healthy people serotonin seems to have a stimulatory role in the regulation of ACTH secretion, and the effect of ketanserin in reducing the ACTH response to hypoglycaemia suggested that it might prove useful in Nelson's syndrome. These results show that it is not indicated in these patients.

Topics: Adrenocorticotropic Hormone; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Humans; Ketanserin; Male; Middle Aged; Nelson Syndrome; Piperidines; Pituitary Neoplasms; Serotonin Antagonists

1984