piperidines and Mandibular-Fractures

Topics: Administration, Oral; Adolescent; Adult; Aged; Aminopyrine; Analgesics; Clinical Trials as Topic; Drug Combinations; Drug Evaluation; Female; Humans; Injections, Intravenous; Male; Mandibular Fractures; Maxillofacial Injuries; Mesylates; Middle Aged; Periodontal Diseases; Piperidines; Surgery, Oral; Tooth Extraction

Topics: Acrylates; Acrylic Resins; Anesthetics; Animals; Bone Transplantation; Cartilage; Clinical Trials as Topic; Cyanates; Fracture Fixation; Haplorhini; Mandibular Fractures; Occlusive Dressings; Phencyclidine; Piperidines; Splints; Tibia; Tissue Adhesives; Transplantation, Homologous; Wound Healing

The safety profile and efficacy were compared for remifentanil and dexmedetomidine with respect to haemodynamic and respiratory response during mask ventilation and laryngoscopy in patients with mandibular fractures.. Seventy patients undergoing elective mandibular fracture surgery were randomly assigned to the remifentanil group (Group R, n = 35) or the dexmedetomidine group (Group D, n = 35). The primary outcomes were preoperative pain scores caused by jaw movement; haemodynamic response; intubation score; and side effects, such as the incidence of oxygen desaturation and muscle rigidity. Other side effects, such as tachycardia, bradycardia, hypertension and hypotension, were also compared.. Preoperative pain scores caused by jaw movement were significantly high for both groups, but there were no statistically significant differences between the groups. The incidence of oxygen desaturation and muscle rigidity was significantly lower in Group D than in Group R (p = 0.025). No significant differences existed between the groups in terms of intubation score, haemodynamics, and other side effects (p > 0.05).. Dexmedetomidine and remifentanil had equal effectiveness on the control of haemodynamic response due to mask ventilation and intubation in patients with mandibular fractures. However, at the doses used in this study, dexmedetomidine had a significant advantage over remifentanil in terms of respiratory stability.

Topics: Adult; Dexmedetomidine; Female; Hemodynamics; Humans; Hypnotics and Sedatives; Laryngoscopy; Male; Mandibular Fractures; Masks; Middle Aged; Piperidines; Preoperative Care; Remifentanil; Respiration, Artificial; Respiratory Mechanics; Treatment Outcome

Topics: Airway Management; Anesthesia, General; Anesthesia, Intravenous; Anesthetics, Intravenous; Atracurium; Biotransformation; Consciousness Monitors; Humans; Intraoperative Complications; Intubation, Intratracheal; Lesch-Nyhan Syndrome; Male; Mandibular Fractures; Nasal Cavity; Neuromuscular Blocking Agents; Neurotransmitter Agents; Piperidines; Preoperative Care; Propofol; Remifentanil; Young Adult