piperidines and Liver-Diseases--Alcoholic

Alcohol-associated liver disease (ALD) is a significant cause of liver-related morbidity and mortality worldwide and with limited therapies. Soluble epoxide hydrolase (sEH; Ephx2) is a largely cytosolic enzyme that is highly expressed in the liver and is implicated in hepatic function, but its role in ALD is mostly unexplored.. To decipher the role of hepatic sEH in ALD, we generated mice with liver-specific sEH disruption (Alb-Cre; Ephx2. These findings elucidated a role for sEH in ALD and validated a pharmacologic inhibitor of this enzyme in a preclinical mouse model as a potential therapeutic approach.

Topics: Animals; Disease Models, Animal; Drug Evaluation, Preclinical; Epoxide Hydrolases; Ethanol; Female; Gene Expression Regulation; Liver; Liver Diseases, Alcoholic; Mice; Mice, Transgenic; Phenylurea Compounds; Piperidines