piperidines and Intermittent-Claudication

The effects of ketanserin, a serotonin antagonist, were studied in 37 patients with intermittent claudication in a double-blind placebo-controlled, trial done in London and Leuven. 40 mg ketanserin taken orally three times a day for 4 months was associated with a clear-cut inhibition of serotonin-induced platelet aggregation but no changes were observed in pain-free and maximum walking distance on a treadmill, in ankle/arm Doppler systolic blood pressure ratio, or in reactive hyperaemia after 3 min of ischaemia. In contrast, the placebo group had increases in both pain-free and maximum walking distance (p less than 0.05).

Topics: Adult; Aged; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Extremities; Female; Humans; Intermittent Claudication; Ketanserin; Male; Middle Aged; Piperidines; Platelet Aggregation; Regional Blood Flow; Serotonin Antagonists

Ketanserin, a selective serotonin (5-HT) antagonist at 5-HT2 receptors, was investigated in a 3-month, double-blind, placebo-controlled study in twenty patients with intermittent claudication. Blood-pressure ratio (thigh/arm), reactive hyperaemia measured with an ECG-triggered venous occlusion plethysmograph, blood filterability, and claudication distance on a treadmill progressively and significantly improved during ketanserin therapy, whereas no such changes occurred in the placebo group. Mean claudication distance improved by 140%; four of the eleven patients on ketanserin were able to keep walking beyond the time limit of the exercise test. The beneficial effect of ketanserin suggests that 5-HT may be involved in the pathogenesis of peripheral arterial obstructive diseases. In an experiment comparing blood-pressure ratio measured by doppler velocimetry and by plethysmography, the plethysmographic values rose during ketanserin therapy only at thigh level, which suggests an improvement in the collateral circulation.

Topics: Aged; Blood Flow Velocity; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Erythrocyte Deformability; Exercise Test; Humans; Intermittent Claudication; Ketanserin; Leg; Middle Aged; Piperidines; Plethysmography; Regional Blood Flow; Serotonin Antagonists

Topics: Aged; Ancrod; Arterial Occlusive Diseases; Blood Pressure; Clinical Trials as Topic; Double-Blind Method; Drug Evaluation; Humans; Hyperemia; Intermittent Claudication; Lactates; Middle Aged; Physical Exertion; Piperidines; Pyruvates

Topics: Humans; Intermittent Claudication; Ketanserin; Piperidines

Topics: Double-Blind Method; Erythrocyte Deformability; Humans; Intermittent Claudication; Ketanserin; Pentoxifylline; Piperidines; Serotonin Antagonists; Theobromine; Vasodilator Agents

Topics: Appetite; Blood Pressure; Body Weight; Humans; Intermittent Claudication; Ketanserin; Piperidines

Topics: Adrenergic alpha-Agonists; Adult; Aged; Arteriosclerosis; Benzamides; Blood Pressure; Female; Fingers; Heart Rate; Humans; Hypotension; Indoles; Injections, Intravenous; Intermittent Claudication; Male; Middle Aged; Piperidines; Pulse; Radioisotopes; Raynaud Disease; Regional Blood Flow; Skin; Time Factors; Toes; Xenon