piperidines and Hantavirus-Pulmonary-Syndrome

Hantaviruses, members of the order

Topics: Adrenal Cortex Hormones; Amides; Animals; Antiviral Agents; Clinical Trials as Topic; Hantavirus Infections; Hantavirus Pulmonary Syndrome; Hemorrhagic Fever with Renal Syndrome; Humans; Immunotherapy; Lactoferrin; Models, Animal; Nucleosides; Orthohantavirus; Piperidines; Pyrazines; Quinazolines; Recombinant Proteins; Ribavirin; Triazoles; Vaccines, Synthetic; Viral Vaccines

Hantavirus pulmonary syndrome (HPS) is a severe disease caused by hantavirus infection of pulmonary microvascular endothelial cells leading to microvascular leakage, pulmonary edema, pleural effusion and high case fatality. Previously, we demonstrated that Andes virus (ANDV) infection caused up-regulation of vascular endothelial growth factor (VEGF) and concomitant downregulation of the cellular adhesion molecule VE-cadherin leading to increased permeability. Analyses of human HPS-patient sera have further demonstrated increased circulating levels of VEGF. Here we investigate the impact of a small molecule antagonist of the VEGF receptor 2 (VEGFR-2) activation in vitro, and overall impact on survival in the Syrian hamster model of HPS.

Topics: Animals; Capillary Permeability; Cricetinae; Disease Models, Animal; Endothelial Cells; Hantavirus Pulmonary Syndrome; Orthohantavirus; Phosphorylation; Piperidines; Protein Kinase Inhibitors; Quinazolines; Vascular Endothelial Growth Factor A; Viral Load

Topics: Animals; California; Cricetinae; Disease Models, Animal; Disease Outbreaks; Hantavirus Pulmonary Syndrome; Humans; Mesocricetus; Orthohantavirus; Piperidines; Quinazolines; Receptors, Vascular Endothelial Growth Factor; United States; Viral Vaccines