piperidines and Gastroenteritis

Topics: Antidiarrheals; Clinical Trials as Topic; Diarrhea; Duodenitis; Gastroenteritis; Humans; Loperamide; Peptic Ulcer; Piperidines

Loperamide at a dose of 0 . 2 mg/kg/day was compared with placebo in the treatment of acute infantile gastro-enteritis in hospital-based double-blind clinical trials carried out in parallel in Liverpool, England and Benghazi, Libya. Fifty patients aged one month to four years entered the study in each centre. Rotavirus was the predominant pathogen isolated in both centres. Pathogenic Escherichia coli was cultured from five children in the Liverpool study only. No statistically significant differences were observed in the duration of diarrhoea, length of stay in hospital or weight gain during the first 48 h after admission, between loperamide and placebo groups in either centre. Loperamide, in the dosage used in this study, appears to have no significant effect on the course of acute gastro-enteritis in early childhood. The possibility that these results may reflect specifically on rotavirus infection is discussed. No toxic effects of loperamide were observed.

Topics: Body Weight; Child, Preschool; Double-Blind Method; Drug Evaluation; Escherichia coli; Female; Gastroenteritis; Humans; Infant; Length of Stay; Loperamide; Male; Piperidines; Prostaglandins E; Rotavirus

In a double-blind trial in 60 children suffering from gastroenteritis complicated by vomiting, it was found that suppositories of domperidone (30 mg) were more effective than either metoclopramide (10 mg) or placebo in reducing the severity of vomiting, nausea and other symptomatic parameters. No side effects were reported throughout the 24 hour period of the trial and the results suggest that domperidone suppositories may well prove to be the drug of choice in such cases of paediatric vomiting.

Topics: Antiemetics; Benzimidazoles; Child; Child, Preschool; Clinical Trials as Topic; Double-Blind Method; Female; Gastroenteritis; Humans; Male; Metoclopramide; Nausea; Piperidines; Suppositories; Vomiting

Topics: Gastroenteritis; Humans; Infant; Loperamide; Male; Piperidines

Topics: Aspirin; Child; Gastroenteritis; Humans; Loperamide; Piperidines

Topics: Acute Disease; Bacterial Infections; Butyrates; Child; Child, Preschool; Diarrhea, Infantile; Enteritis; Gastroenteritis; Gastrointestinal Agents; Humans; Infant; Infant, Newborn; Piperidines; Virus Diseases

Topics: Biomedical Research; Colchicine; Colectomy; Colitis; Colitis, Ulcerative; Colonic Diseases; Colonic Diseases, Functional; Crohn Disease; Diabetic Neuropathies; Diarrhea; Diphenoxylate; Diverticulitis; Diverticulitis, Colonic; Drug Therapy; Dysentery; Dysentery, Amebic; Enteritis; Gastroenteritis; Humans; Piperidines; Postgastrectomy Syndromes; Postoperative Complications; Toxicology; Virus Diseases