piperidines and Failure-to-Thrive

piperidines has been researched along with Failure-to-Thrive* in 2 studies

Other Studies

2 other study(ies) available for piperidines and Failure-to-Thrive

Article	Year
Airway management and fiberoptic tracheal intubation via the laryngeal mask in a child with Marshall-Smith syndrome. Paediatric anaesthesia, 2008, Volume: 18, Issue:4 Topics: Airway Obstruction; Anesthetics, Inhalation; Anesthetics, Intravenous; Failure to Thrive; Fiber Optic Technology; Glaucoma; Humans; Infant; Intellectual Disability; Intubation, Intratracheal; Laryngeal Masks; Male; Maxillofacial Abnormalities; Methyl Ethers; Monitoring, Physiologic; Piperidines; Rare Diseases; Remifentanil; Sevoflurane; Syndrome	2008
Inhibition of milk ingestion and growth after administration of a neutral cannabinoid CB1 receptor antagonist on the first postnatal day in the mouse. Pediatric research, 2007, Volume: 62, Issue:5 We have shown previously that neonatal exposure to the cannabinoid CB1 receptor antagonist/inverse agonist rimonabant (SR141716) interfered with suckling and development. However, it was not clear whether the developmental deficiencies were induced by neutral CB1 receptor blockade, thereby inhibiting endogenous cannabinoid "tone," or by inverse agonist reduction of constitutive CB1 receptors. CB1 receptor blockade supports our hypothesis that low CB1 receptor concentrations and/or reduced endocannabinoid levels underlie infant nonorganic failure to thrive (NOFTT). Inverse agonism implies that lower constitutive CB1 receptor activity may be responsible for impaired food intake in newborns. In the present study, we injected the neutral CB1 receptor antagonist 5-(4-chlorophenyl)-3-[(E)-2-cyclohexylethenyl]-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole (VCHSR1) to 1-d-old mouse pups and recorded weight gain, gastric milk contents (milkbands), axillary temperature, and survival between age 1 and 10 d. The results showed a dose-related interference with all measures. These data show that (1) growth failure induced by rimonabant is generalized to another CB1 antagonist and (2) cannabinoid CB1 receptor activation by endocannabinoids is essential for normal milk ingestion and development in mice. This supports our hypothesis that endocannabinoid deficiency and perhaps CB1 receptor dysfunction represents the uncharacterized biologic vulnerability, which underlies NOFTT. Topics: Animals; Animals, Newborn; Body Temperature; Body Weight; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Eating; Failure to Thrive; Female; Injections, Subcutaneous; Male; Mice; Milk; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors	2007

Article

Year

Airway management and fiberoptic tracheal intubation via the laryngeal mask in a child with Marshall-Smith syndrome.

Paediatric anaesthesia, 2008, Volume: 18, Issue:4

Topics: Airway Obstruction; Anesthetics, Inhalation; Anesthetics, Intravenous; Failure to Thrive; Fiber Optic Technology; Glaucoma; Humans; Infant; Intellectual Disability; Intubation, Intratracheal; Laryngeal Masks; Male; Maxillofacial Abnormalities; Methyl Ethers; Monitoring, Physiologic; Piperidines; Rare Diseases; Remifentanil; Sevoflurane; Syndrome

2008

Inhibition of milk ingestion and growth after administration of a neutral cannabinoid CB1 receptor antagonist on the first postnatal day in the mouse.

Pediatric research, 2007, Volume: 62, Issue:5

We have shown previously that neonatal exposure to the cannabinoid CB1 receptor antagonist/inverse agonist rimonabant (SR141716) interfered with suckling and development. However, it was not clear whether the developmental deficiencies were induced by neutral CB1 receptor blockade, thereby inhibiting endogenous cannabinoid "tone," or by inverse agonist reduction of constitutive CB1 receptors. CB1 receptor blockade supports our hypothesis that low CB1 receptor concentrations and/or reduced endocannabinoid levels underlie infant nonorganic failure to thrive (NOFTT). Inverse agonism implies that lower constitutive CB1 receptor activity may be responsible for impaired food intake in newborns. In the present study, we injected the neutral CB1 receptor antagonist 5-(4-chlorophenyl)-3-[(E)-2-cyclohexylethenyl]-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole (VCHSR1) to 1-d-old mouse pups and recorded weight gain, gastric milk contents (milkbands), axillary temperature, and survival between age 1 and 10 d. The results showed a dose-related interference with all measures. These data show that (1) growth failure induced by rimonabant is generalized to another CB1 antagonist and (2) cannabinoid CB1 receptor activation by endocannabinoids is essential for normal milk ingestion and development in mice. This supports our hypothesis that endocannabinoid deficiency and perhaps CB1 receptor dysfunction represents the uncharacterized biologic vulnerability, which underlies NOFTT.

Topics: Animals; Animals, Newborn; Body Temperature; Body Weight; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Eating; Failure to Thrive; Female; Injections, Subcutaneous; Male; Mice; Milk; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Time Factors

2007