piperidines and Enterocolitis--Pseudomembranous

We report on one patient in whom segmental colic intestinal pseudo-obstruction (IPO) following the surgical treatment of a grade III necrotising enterocolitis (NEC) was responsible for a severe failure to thrive. Further intestinal resection in an already short gut was avoided by using Cisapride, a new intestinal prokinetic agent (1 mg/kg/d in 4 doses, orally), which dramatically improved the symptoms and allowed weight gain and intestinal adaptation. After 6 months, Cisapride was withdrawn. IPO did not recur after 2 years of follow-up, although proximal distention persisted.

Topics: Cisapride; Colonic Pseudo-Obstruction; Enteral Nutrition; Enterocolitis, Pseudomembranous; Follow-Up Studies; Humans; Ileostomy; Infant; Infant, Newborn; Infant, Premature, Diseases; Male; Piperidines; Postoperative Complications; Serotonin Antagonists

Two cases of necrotising enterocolitis (NEC) occurring in infants beyond the neonatal period were reported. They did not have any predisposing factors to NEC but both had paralytic ileus after loperamide therapy for their mild diarrhoea prior to the onset of NEC. The possible role of loperamide in the pathogenesis of NEC was discussed.

Topics: Enterocolitis, Pseudomembranous; Female; Humans; Infant; Loperamide; Piperidines

Topics: Adult; Chronic Disease; Colitis; Enterocolitis, Pseudomembranous; Female; Humans; Intestinal Diseases, Parasitic; Male; Middle Aged; Piperidines