piperidines and Dysmenorrhea

Menstrual migraines are particularly difficult-totreat. Few studies on the use of triptans in short-term prophylaxis of menstrually related migraine have been recently conducted, but evidences of triptans' efficacy in the specific case of pure menstrual migraine (PMM) are lacking. The aim of this study is to explore the efficacy and tolerability of naratriptan as short-term prophylaxis of pure menstrual migraine (PMM) attacks. A multi-centre, open, non comparative, pilot six-month study was conducted in women, aged 18 years or older, with regular menstrual cycles and with a history of migraine without aura exclusively associated to the perimenstrual period. After an observation period of three months, patients took for three consecutive menstrual cycles oral naratriptan 1 mg twice daily, starting two days before the expected onset of menstruation and continuing for six days. Ninety-eight women with a history of PMM were screened for study participation, and 61 entered the study. Fifty-nine comprised the intent-to-treat population. The mean number of PMM attacks decreased from 3.5+/-1.4 in the 3-month observation period to 1.6+/-1.3 in the 3-month treatment with naratriptan. The pecentage of responders (subjects who recorded a decrease-equal or more than 50%-in the mean number of attacks) was 61.4%. A tendency towards a decrease in headache severity and in the presence of associated symptoms was observed during treatment. At least one adverse event during the treatment period was reported by 19 patients (31.1%). No serious adverse events occurred. Naratriptan may be an effective and safe treatment option in the short-prophylaxis of PMM.

Topics: Adolescent; Adult; Drug Evaluation; Dysmenorrhea; Female; Follow-Up Studies; Humans; Indoles; Middle Aged; Migraine Disorders; Pain Measurement; Piperidines; Serotonin Receptor Agonists; Time Factors; Treatment Outcome; Tryptamines

Topics: Adult; Aged; Anti-Inflammatory Agents; Antiemetics; Benzimidazoles; Clinical Trials as Topic; Craniocerebral Trauma; Dihydroxyphenylalanine; Dysmenorrhea; Esophagoscopy; Female; Humans; Male; Middle Aged; Migraine Disorders; Nausea; Piperidines; Premedication; Radiotherapy; Renal Dialysis; Vomiting

Dipyrone-induced adverse skin reactions appear within the first seven days of drug administration, and the aetiology is often missed. A patient who regularly consumed dipyrone for dysmenorrhoea is presented. The adverse cutaneous manifestations may be predictive of the occurrence of severe haematological adverse reactions. Adverse drug reactions (ADR) should be documented, and initiation of ADR monitoring units in the Caribbean will be a step in establishing a data base of these events in Caribbean populations.

Topics: Adult; Adverse Drug Reaction Reporting Systems; Benzophenones; Dipyrone; Drug Combinations; Drug Eruptions; Dysmenorrhea; Female; Humans; Parasympatholytics; Piperidines; Trinidad and Tobago

Topics: Adult; Aged; Biliary Tract Diseases; Colitis, Ulcerative; Dioxoles; Dysmenorrhea; Female; Humans; Male; Middle Aged; Parasympatholytics; Piperidines; Tablets; Urinary Calculi

Topics: Adult; Aged; Asthma; Biliary Tract Diseases; Dioxoles; Drug Tolerance; Duodenal Diseases; Dysmenorrhea; Esophagitis; Female; Gastritis; Heart Diseases; Humans; Kidney Calculi; Male; Middle Aged; Migraine Disorders; Muscles; Piperidines; Spasm