piperidines and Disease

AdipoRon is the first synthetic analog of endogenous adiponectin, an adipose tissue-derived hormone. AdipoRon possesses pharmacological properties similar to adiponectin and its ability to bind and activate the adipoR1 and adipoR2 receptors makes it a suitable candidate for the treatment of a multitude of disorders.. In the present review, an attempt was made to compile and discuss the efficacy of adipoRon against various disorders.. AdipoRon is a drug that acts not only in metabolic diseases but in other conditions unrelated to energy metabolism. It is well- reported that adipoRon exhibits strong anti-obesity, anti-diabetic, anticancer, anti-depressant, anti-ischemic, anti-hypertrophic properties and also improves conditions like post-traumatic stress disorder, anxiety, and systemic sclerosis.. A lot is known about its effects in experimental systems, but the translation of this knowledge to the clinic requires studies which, for many of the potential target conditions, have yet to be carried out. The beneficial effects of AdipoRon in novel clinical conditions will suggest an underlying pathophysiological role of adiponectin and its receptors in previously unsuspected settings.

Topics: Animals; Behavior; Disease; Humans; Insulin; Piperidines; Signal Transduction

Rhodamine S could emit strong and stable room temperature phosphorescence (RTP) on polyamide membrane (PAM) in the presence of heavy atom perturber Pb(2+). When Rhodamine S-piperidine solution was dropped on PAM, the red (Rhod.S)(n)-P-SOR (Rhod.S, (Rhod.S)(n), P and SOR refer to alizarin red S, multiple Rhod.S molecules, piperidine and self-ordered ring, respectively) formed on PAM, leading to the enhancement of room temperature phosphorimetry (RTP) intensity (I(p), 117.2) of (Rhod.S)(n)-P-SOR system, which was 2.4 times higher than that without SOR (I(p), 48.1). Wheat germ agglutinin (WGA) was labelled with (Rhod.S)(n)-P-SOR by the -NH- of Rhod.S reacting with the -COOH of WGA to form WGA-(Rhod.S)(n)-P-SOR. The formation of WGA-AP-WGA-(Rhod.S)(n)-P-SOR in the affinity adsorption (AA) reaction carried out between the -COOH of WGA in WGA-(Rhod.S)(n)-P-SOR and the -NH(2) of alkaline phosphatase (AP) caused the RTP intensity (ΔI(p)) of the WGA-AP-WGA-(Rhod.S)(n)-P-SOR system 7.8 times larger than that without (Rhod.S)(n)-P-SOR. Therefore, the coupling technique of SOR and solid substrate-room temperature phosphorimetry (SS-RTP) for the determination of trace AP has been established. This method possessed good selectivity, high sensitivity (Detection limit (L.D) was 3.4×10(-16)gmL(-1)) and accuracy, and it has been applied to the determination of trace AP in human serum and the forecast of human diseases, and the results agreed well with those obtained by enzyme-linked immunoassay (ELISA). Besides, the mechanism of the coupling technique for the determination of AP was discussed.

Topics: Alkaline Phosphatase; Anthraquinones; Buffers; Disease; Humans; Limit of Detection; Luminescent Measurements; Piperidines; Rhodamines; Solvents; Substrate Specificity; Temperature; Wheat Germ Agglutinins

Aging alters both the pharmacokinetic and the pharmacodynamic aspects of anesthetic requirement. Studies of the relationship between drug concentration and effect in older adults clearly demonstrate a decline in median effective dose requirement for agents that act within the central nervous system, but there appears to be little change in the dose required for peripheral effects such as neuromuscular blockade. Most drugs also undergo somewhat slower biotransformation and demonstrate prolonged clinical effects if they require hepatic or renal degradation, although many newer agents such as remifentanil and cisatracurium have organ-independent pathways that are not affected by age. In some cases, however, the appearance of increased sensitivity to a given dose of anesthetic or opiate may actually reflect higher-than expected plasma concentrations of drug following a rapid intravenous injection. Therefore, it is impossible to completely separate the interactions between pharmacodynamic and pharmacokinetic factors associated with aging. The use of pharmacological sympathectomy with intrathecal agents and with sympatholytic adrenergic agonists may further improve outcome in a patient population at high risk because of reduced functional reserve, increased incidence of polypharmacy, and the consequences of age-related disease.

Topics: Adrenergic Agonists; Adult; Aged; Aged, 80 and over; Aging; Anesthetics, Intravenous; Atracurium; Brain; Disease; Dose-Response Relationship, Drug; Humans; Incidence; Injections, Spinal; Kidney; Liver; Middle Aged; Narcotics; Neuromuscular Blockade; Neuromuscular Blocking Agents; Peripheral Nerves; Piperidines; Polypharmacy; Remifentanil; Risk Factors; Spinal Cord; Sympathectomy, Chemical; Sympatholytics

Topics: Animals; Blood Proteins; Carnivora; Disease; Ethylenes; Foxes; Humans; Piperazines; Piperidines; Silver; Tetrachloroethylene

Topics: Benzilates; Diarrhea; Disease; Double-Blind Method; Humans; Intestinal Diseases; Intestines; Parasympatholytics; Piperidines

Topics: Disease; Mental Disorders; Piperidines; Psychosurgery; Psychotic Disorders; Veterans

Topics: Aged; Anxiety; Anxiety Disorders; Disease; Humans; Piperidines; Psychomotor Agitation; Reserpine

Topics: Benzilates; Cholinergic Antagonists; Colon; Colonic Diseases; Disease; Muscle Relaxants, Central; Piperidines

Topics: Aged; Antihypertensive Agents; Central Nervous System Stimulants; Disease; Mental Disorders; Methylphenidate; Piperidines; Reserpine; Secologanin Tryptamine Alkaloids

Topics: Anti-Allergic Agents; Collapse Therapy; Disease; Histamine H1 Antagonists; Piperidines; Pleura; Pleural Diseases; Pleural Effusion

Topics: Aged; Anticonvulsants; Chronic Disease; Disease; Hypnotics and Sedatives; Piperidines; Sleep Wake Disorders

Topics: Cholinergic Antagonists; Disease; Duodenum; Gastritis; Humans; Parasympatholytics; Peptic Ulcer; Piperidines; Stomach Diseases