piperidines and Churg-Strauss-Syndrome

Topics: Adult; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Blood Sedimentation; C-Reactive Protein; Churg-Strauss Syndrome; Female; Granulomatosis with Polyangiitis; Humans; Janus Kinase Inhibitors; Male; Microscopic Polyangiitis; Middle Aged; Pilot Projects; Piperidines; Pyrimidines; Treatment Outcome; Young Adult

Churg-Strauss syndrome (CSS) is an uncommon disease characterized by bronchial asthma, eosinophilia and systemic vasculitis. Many patients with CSS are suffering from cardiovascular disorders, neurological disorders and/or renal disorders which are associated with systemic vasculitis. Cardiac diseases are considered as the main cause of the death in patients with CSS. Steroid administration is the standard pharmacological therapy for CSS. There are very few clinical reports concerning anesthetic management for the patients with CSS. We suppose that precise perioperative managements are required for the patients with CSS, including the appropriate control of bronchial asthma and the careful treatments of disorders in cardiovascular system, neurological system and/or kidney. In addition, we believe that the steroid cover should be considered during the perioperative period of the patients with CSS. Here, we describe an anesthetic management of a 28-year-old man with CSS undergoing laparoscopic cholecystectomy. General anesthesia was induced with midazolam and fentanyl. Rocuronium was administered to facilitate tracheal intubation. After tracheal intubation, anesthesia was maintained with sevoflurane and remifentanil. Prior to the surgery, 100 mg of hydrocortisone was administered for the steroid cover. The surgery was uneventful. The patient emerged from general anesthesia smoothly, and was extubated safely.

Topics: Adult; Anesthesia, General; Cholecystectomy, Laparoscopic; Churg-Strauss Syndrome; Fentanyl; Humans; Male; Methyl Ethers; Midazolam; Piperidines; Remifentanil; Sevoflurane

Topics: Asthma; Benzamides; Churg-Strauss Syndrome; Humans; Male; Middle Aged; Piperidines; Protein-Tyrosine Kinases; Pyridines; Thiazoles; Treatment Outcome