piperidines has been researched along with Cardiomyopathy--Dilated* in 6 studies
6 other study(ies) available for piperidines and Cardiomyopathy--Dilated
Article | Year |
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Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy.
Myocardial metabolic impairment is a major feature in chronic heart failure. As the major coenzyme in fuel oxidation and oxidative phosphorylation and a substrate for enzymes signaling energy stress and oxidative stress response, nicotinamide adenine dinucleotide (NAD. To explore possible alterations of NAD. We observed a 30% loss in levels of NAD. The data show that nicotinamide riboside, the most energy-efficient among NAD precursors, could be useful for treatment of heart failure, notably in the context of DCM, a disease with few therapeutic options. Topics: Acrylamides; AMP-Activated Protein Kinases; Animals; Cardiomyopathy, Dilated; Citric Acid; Cytokines; Dietary Supplements; Disease Models, Animal; Gene Expression Profiling; Heart Failure; Metabolome; Mice; Mice, Transgenic; Myocytes, Cardiac; NAD; Niacinamide; Nicotinamide Phosphoribosyltransferase; Phosphotransferases (Alcohol Group Acceptor); Piperidines; PPAR alpha; Pyridinium Compounds; Rats; Serum Response Factor | 2018 |
Is sevoflurane and remifentanil induction of anesthesia safe in children with severe dilated cardiomyopathy?
Topics: Analgesics, Opioid; Anesthetics, Inhalation; Cardiomyopathy, Dilated; Female; Humans; Infant; Methyl Ethers; Piperidines; Remifentanil; Sevoflurane | 2008 |
Endothelin B receptors located on the endothelium provide cardiovascular protection in the hamster.
Endothelins (ETs) act through two receptors, namely ET(A) and ET(B). In the cardiovascular system, the activation of both receptors leads to vasoconstriction. However, ET(B) receptors also mediate endothelium-dependent vasodilatation and clearance of plasma ET-1. With regard to these latter properties, we wanted to assess the contribution of ET(B) receptors and the effects of selective and mixed ET receptor blockade on vascular tone in control Syrian Golden hamsters and in Bio 14.6 cardiomyopathic hamsters after bolus injection of ET-1 and IRL-1620, a selective ET(B) agonist. In 12-week-old anaesthetized control hamsters, ET-1 (0.5 nmol/kg) induced a sustained pressor response which was only partly reduced by the selective ET(A) receptor antagonist BQ-123, suggesting a contribution of ET(B) receptor activation to the vasoconstrictive effects of ET-1. This was confirmed by injection of the selective ET(B) receptor agonist IRL-1620 (1 nmol/kg). However, the pressor response to this agonist was always preceded by a transient vasodilatation, indicating activation of endothelium-located ET(B) receptors. When the selective ET(B) receptor antagonist BQ-788 was administered, the hypotensive phase following IRL-1620 injection was abolished. Interestingly, BQ-788 or a mixture of BQ-788 and BQ-123 significantly potentiated the pressor responses to ET-1. In 12-week-old Bio 14.6 cardiomyopathic hamsters, ET-1 and IRL-1620 induced haemodynamic responses similar to those observed in control hamsters, although the IRL-1620-induced pressor increase was lower. No difference in cardiac prepro ET-1 mRNA expression was observed between the two strains of hamsters. In conclusion, we suggest that endothelium-located ET(B) receptors are involved in the physiological antagonism of ET-dependent protracted pressor effects, and thus may play a protective role in both normal hamsters and those with cardiomyopathy. Topics: Animals; Blood Pressure; Cardiomyopathy, Dilated; Cricetinae; Endothelin Receptor Antagonists; Endothelin-1; Endothelins; Endothelium; Mesocricetus; Oligopeptides; Peptide Fragments; Peptides, Cyclic; Piperidines; Receptor, Endothelin A; Receptor, Endothelin B; Receptors, Endothelin; Vasoconstrictor Agents | 2002 |
Use of remifentanil in a patient with peripartum cardiomyopathy requiring Caesarean section.
We describe a case of a 26 yr old primigravida at 39 weeks' gestation, with a diagnosis of peripartum cardiomyopathy, requiring urgent Caesarean section. The patient presented in severe heart failure and active labour. A general anaesthetic, using a target-controlled infusion of propofol and an intravenous infusion of remifentanil, was used to provide stable anaesthesia and analgesia for a successful delivery. The unusual diagnosis of peripartum cardiomyopathy and the potential benefits of the use of remifentanil in high-risk obstetric surgery are discussed. Topics: Adult; Analgesics, Opioid; Anesthesia, Intravenous; Anesthesia, Obstetrical; Anesthetics, Combined; Anesthetics, Intravenous; Cardiomyopathy, Dilated; Cesarean Section; Female; Humans; Obstetric Labor Complications; Piperidines; Pregnancy; Propofol; Remifentanil | 2001 |
Target-controlled intravenous anaesthesia with bispectral index monitoring for thoracotomy in a patient with severely impaired left ventricular function.
The anaesthetic management of an elderly patient with severely impaired left ventricular function undergoing thoracotomy and lobectomy is described. Total intravenous anaesthesia (TIVA) with remifentanil and target-controlled infusion of propofol titrated according to the bispectral index (BIS) was used, with thoracic epidural anaesthesia commenced at the end of surgery providing postoperative analgesia. Avoidance of intraoperative epidural local anaesthetics and careful titration and dose reduction of propofol using the BIS was associated with excellent haemodynamic stability. The rapid offset of action of remifentanil and low-dose propofol facilitated early recovery and tracheal extubation. The BIS was a valuable monitor in optimal titration of TIVA. Topics: Aged; Analgesia, Epidural; Anesthesia Recovery Period; Anesthesia, Intravenous; Anesthetics, Intravenous; Carcinoma, Squamous Cell; Cardiomyopathy, Dilated; Electroencephalography; Hemodynamics; Humans; Infusions, Intravenous; Intubation, Intratracheal; Lung Neoplasms; Male; Monitoring, Intraoperative; Piperidines; Pneumonectomy; Propofol; Remifentanil; Signal Processing, Computer-Assisted; Thoracotomy; Titrimetry; Ventricular Dysfunction, Left | 2000 |
Delayed rectifier channels in human ventricular myocytes.
Previous studies have shown that in heart there are two kinetically distinct components of delayed rectifier current: a rapidly activating component (IKr) and a more slowly activating component (IKs). The presence of IKr and/or IKs appears to be species dependent. We studied the nature of the delayed rectifier current in human ventricle in whole-cell and single-channel experiments.. Ventricular myocytes were obtained from hearts of patients with ischemic or dilated cardiomyopathy. Single-channel currents and whole-cell tail currents were recorded at negative potentials directly after return from a depolarizing step. Single-channel currents were measured in the cell-attached patch configuration with 140 mmol/L K+ in the pipette. In the present study, we identified a voltage-dependent channel with a single-channel conductance of 12.9 +/- 0.8 pS (mean +/- SEM, n = 5) and a reversal potential near to the K+ equilibrium potential, suggesting that the channel is selective to K+ ions. Channel activity was observed only after a depolarizing step and increased with the duration and amplitude of the depolarization, indicating time- and voltage-dependent activation. Activation at +30 mV was complete within 300 milliseconds, and the time constant of activation, determined in the whole-cell configuration, was 101 +/- 25 milliseconds (mean +/- SEM, n = 4). The voltage dependence of activation could be described by a Boltzmann equation with a half-activation potential of -29.9 mV and a slope factor of 9.5 mV. The addition of the class III antiarrhythmic drug E-4031 completely blocked channel activity in one patch. No indications for the presence of IKs were found in these experiments.. The conformity between the properties of IKr and those of the K+ channel in the present study strongly suggests that IKr is present in human ventricle. Topics: Action Potentials; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Cells, Cultured; Heart Ventricles; Humans; Myocardial Ischemia; Myocardium; Piperidines; Potassium Channels; Pyridines | 1995 |