piperidines and Cadmium-Poisoning

The protective effect of three dithiocarbamates against lung tissue damage induced by a single intratracheal instillation of cadmium chloride was examined in rats. The relative efficacy of these compounds was tested by comparing characteristic features of lung tissue damage: the increase of lung weight, and the changes in the synthesis and content of structural proteins. Of three compounds administered intraperitoneally at a dose of 2.46 mmol/kg body weight, the most effective in suppressing lung damage was sodium bis(hydroxyethyl)dithiocarbamate (DEDTC). Its efficacy was dependent on the time interval between administration of cadmium chloride and the DEDTC. The parameters of lung tissue damage which were examined approached control values when DEDTC and cadmium chloride were administered simultaneously.

Topics: Animals; Cadmium; Cadmium Poisoning; Connective Tissue; Copper; Ditiocarb; Lung; Lung Diseases; Male; Organ Size; Piperidines; Poisoning; Rats; Rats, Inbred Strains; Sorbitol; Thiocarbamates; Zinc

Effects of ip treatment with diethyldithiocarbamate (DDTC), 4-carboxamidopiperidine-N-dithiocarboxylate (CAP-N-DTC), and N-methyl-N-dithiocarboxyglucamine (MDCG) on cadmium (Cd) levels in selected mouse organs and tissues were assessed after mice were offered deionized water containing 0.05 mg/ml of CdCl2 X 2.5 H2O, 10 mg/ml of sucrose, and 0.125 microCi/ml of carrier-free 109-CdCl2 as the sole drinking fluid for 15 days. Only 0.31 +/- 0.01 % of the ingested Cd was absorbed. Data obtained following treatment were compared with those obtained earlier in similar studies following ip Cd injection. In contrast to its action when administered after ip Cd injection, DDTC enhanced hepatic Cd burdens in mice which received Cd po. DDTC did, however, reduce renal Cd levels markedly after Cd ingestion, while enhancing brain Cd levels. CAP-N-DTC and MDCG, which were shown earlier to have no effect on Cd levels in striated muscle following ip Cd administration, effected significant reduction of muscle Cd concentrations after Cd administration po, while also reducing hepatic and renal Cd levels significantly. It was concluded that certain dithiocarbamates effectively mobilize and promote excretion of Cd which has been absorbed from one of the natural portals of entry.

Topics: Administration, Oral; Animals; Body Burden; Cadmium; Cadmium Poisoning; Carbamates; Chelating Agents; Ditiocarb; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Piperidines; Sorbitol; Spin Labels; Thiocarbamates; Tissue Distribution