piperazine has been researched along with Benign Neoplasms in 13 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "The metabolic activation of small-molecule drugs into electrophilic reactive metabolites is widely recognized as an indicator of idiosyncratic adverse drug reactions (IADRs)." | 1.91 | Piperazine ring toxicity in three novel anti-breast cancer drugs: an in silico and in vitro metabolic bioactivation approach using olaparib as a case study. ( Abuelizz, HA; Alsubi, TA; Attwa, MW; Darwish, HW; Kadi, AA, 2023) |
| "Piperazine is a structural element present in drugs belonging to various chemical classes and used for numerous different therapeutic applications; it has been considered a privileged scaffold for drug design." | 1.72 | The piperazine scaffold for novel drug discovery efforts: the evidence to date. ( Braconi, L; Dei, S; Gabellini, A; Manetti, D; Romanelli, MN; Teodori, E, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (23.08) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 3 (23.08) | 2.80 |
| Authors | Studies |
|---|---|
| Lin, R | 1 |
| Elf, S | 1 |
| Shan, C | 1 |
| Kang, HB | 1 |
| Ji, Q | 1 |
| Zhou, L | 1 |
| Hitosugi, T | 1 |
| Zhang, L | 1 |
| Zhang, S | 2 |
| Seo, JH | 1 |
| Xie, J | 1 |
| Tucker, M | 1 |
| Gu, TL | 1 |
| Sudderth, J | 1 |
| Jiang, L | 1 |
| Mitsche, M | 1 |
| DeBerardinis, RJ | 1 |
| Wu, S | 1 |
| Li, Y | 1 |
| Mao, H | 1 |
| Chen, PR | 1 |
| Wang, D | 1 |
| Chen, GZ | 1 |
| Hurwitz, SJ | 1 |
| Lonial, S | 1 |
| Arellano, ML | 1 |
| Khoury, HJ | 1 |
| Khuri, FR | 1 |
| Lee, BH | 1 |
| Lei, Q | 1 |
| Brat, DJ | 1 |
| Ye, K | 1 |
| Boggon, TJ | 1 |
| He, C | 1 |
| Kang, S | 1 |
| Fan, J | 1 |
| Chen, J | 1 |
| Romanelli, MN | 1 |
| Manetti, D | 1 |
| Braconi, L | 1 |
| Dei, S | 1 |
| Gabellini, A | 1 |
| Teodori, E | 1 |
| Teng, C | 1 |
| Dang, H | 1 |
| Xu, Y | 1 |
| Yin, D | 1 |
| Yan, L | 1 |
| Alsubi, TA | 1 |
| Attwa, MW | 1 |
| Darwish, HW | 1 |
| Abuelizz, HA | 1 |
| Kadi, AA | 1 |
| Makowski, K | 1 |
| Vigevani, L | 1 |
| Albericio, F | 1 |
| Valcárcel, J | 1 |
| Álvarez, M | 1 |
| Zhu, GX | 1 |
| Cheng, PL | 1 |
| Goto, M | 1 |
| Zhang, N | 1 |
| Morris-Natschke, SL | 1 |
| Hsieh, KY | 1 |
| Yang, GZ | 1 |
| Yang, QR | 1 |
| Liu, YQ | 1 |
| Chen, HL | 1 |
| Zhang, XS | 1 |
| Lee, KH | 1 |
| Azéma, J | 1 |
| Guidetti, B | 1 |
| Dewelle, J | 1 |
| Le Calve, B | 1 |
| Mijatovic, T | 1 |
| Korolyov, A | 1 |
| Vaysse, J | 1 |
| Malet-Martino, M | 1 |
| Martino, R | 1 |
| Kiss, R | 1 |
| Galisteo, J | 1 |
| Navarro, P | 1 |
| Campayo, L | 1 |
| Yunta, MJ | 1 |
| Gómez-Contreras, F | 1 |
| Villa-Pulgarin, JA | 1 |
| Sierra, BG | 1 |
| Mollinedo, F | 1 |
| Gonzalez, J | 1 |
| Garcia-España, E | 1 |
| CROSSLEY, ML | 1 |
| ALLISON, JB | 1 |
| SEEGER, DR | 1 |
| KUH, E | 1 |
| DAVIES, A | 1 |
| WIBIN, E | 1 |
| HOPPE, E | 1 |
| DEPEYSTER, F | 1 |
| ZIDERMANE, AA | 1 |
| KRAVCHENKO, IM | 1 |
| Yi, EY | 1 |
| Jeong, EJ | 1 |
| Song, HS | 1 |
| Lee, MS | 1 |
| Kang, DW | 1 |
| Joo, JH | 1 |
| Kwon, HS | 1 |
| Lee, SH | 1 |
| Park, SK | 1 |
| Chung, SG | 1 |
| Cho, EH | 1 |
| Kim, YJ | 1 |
| McConnell, RM | 1 |
| Green, AW | 1 |
| Trana, CJ | 1 |
| McConnell, MS | 1 |
| Lindley, JF | 1 |
| Sayyar, K | 1 |
| Godwin, WE | 1 |
| Hatfield, SE | 1 |
1 review available for piperazine and Benign Neoplasms
| Article | Year |
|---|---|
6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling.
Topics: AMP-Activated Protein Kinase Kinases; AMP-Activated Protein Kinases; Humans; Lipogenesis; Neoplasms; | 2015 |
12 other studies available for piperazine and Benign Neoplasms
| Article | Year |
|---|---|
The piperazine scaffold for novel drug discovery efforts: the evidence to date.
Topics: Drug Design; Drug Discovery; Humans; Neoplasms; Piperazine; Receptors, Nicotinic | 2022 |
J-aggregates of Br- and piperazine-modified cyanine dye with the assistance of amphiphilic polypeptides for efficient NIR-IIa phototheranostics under 1064 nm irradiation.
Topics: Animals; Cell Line, Tumor; Coloring Agents; Mice; Nanoparticles; Neoplasms; Optical Imaging; Peptide | 2022 |
Piperazine ring toxicity in three novel anti-breast cancer drugs: an in silico and in vitro metabolic bioactivation approach using olaparib as a case study.
Topics: Animals; Antineoplastic Agents; Chromatography, Liquid; Neoplasms; Piperazine; Piperazines; Rats; Ta | 2023 |
Sudemycin K: A Synthetic Antitumor Splicing Inhibitor Variant with Improved Activity and Versatile Chemistry.
Topics: Antineoplastic Agents; Dioxanes; HeLa Cells; Humans; Neoplasms; Piperazine; Piperazines; RNA Precurs | 2017 |
Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives.
Topics: Antineoplastic Agents; Camptothecin; Cell Line, Tumor; Cell Survival; Drug Design; Drug Screening As | 2017 |
7-((4-Substituted)piperazin-1-yl) derivatives of ciprofloxacin: synthesis and in vitro biological evaluation as potential antitumor agents.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Ciprofloxacin; Humans; Maximum | 2009 |
Synthesis and cytotoxic activity of a new potential DNA bisintercalator: 1,4-Bis{3-[N-(4-chlorobenzo[g]phthalazin-1-yl)aminopropyl]}piperazine.
Topics: Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; DNA; Drug Screening Assays, Antitumor; | 2010 |
Chemotherapy of tumors in rats with piperazine-1, 4-bis (N, N'-diethylenephosphondiamide). IV.
Topics: Animals; Antineoplastic Agents; Neoplasms; Neoplasms, Experimental; Piperazine; Piperazines; Rats | 1957 |
The experimental superiority of A8103 (piperazine derivative) over other agents in prevention of tumor growth.
Topics: Antineoplastic Agents; Humans; Neoplasms; Piperazine; Piperazines | 1960 |
[THE SPECTRUM AND EFFECTS ON THE LEUKOPOIESIS OF 1,4-BIS-(2,3-EPOXYPROPYL)-PIPERAZINE].
Topics: Animals; Antineoplastic Agents; Leukocyte Count; Leukopoiesis; Mice; Neoplasms; Neoplasms, Experimen | 1963 |
Anti-angiogenic and anti-tumor apoptotic activities of SJ-8002, a new piperazine derivative.
Topics: Aminopyridines; Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Apoptosis; Biological Assay | 2004 |
New cathepsin d inhibitors with hydroxyethylamine isosteres: preparation and characterization.
Topics: Alzheimer Disease; Antineoplastic Agents; Aspartic Acid Endopeptidases; Carboxylic Acids; Cathepsin | 2006 |