piperazine has been researched along with Ache in 9 studies
| Excerpt | Relevance | Reference |
|---|---|---|
| "A series of piperazine ureas were designed, synthesized, and evaluated for their potential as novel orally efficacious fatty acid amide hydrolase (FAAH) inhibitors for the treatment of neuropathic and inflammatory pain." | 3.80 | Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors. ( Fujimoto, S; Imaeda, T; Kawamura, T; Kono, M; Kori, M; Kosugi, Y; Matsui, H; Matsumoto, T; Odani, T; Shimizu, Y; Shimojo, M, 2014) |
| "A series of piperazine ureas was designed, synthesized, and evaluated for their potential as novel orally available fatty acid amide hydrolase (FAAH) inhibitors that are therapeutically effective against pain." | 3.79 | Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors. ( Behnke, CA; Igaki, S; Kawamura, T; Kiyota, Y; Kono, M; Kori, M; Matsumoto, T; Miyazaki, J; Nishimura, A; Oki, H; Shimojo, M, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 4 (44.44) | 24.3611 |
| 2020's | 3 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Shang, Y | 1 |
| Wang, M | 1 |
| Hao, Q | 1 |
| Meng, T | 1 |
| Li, L | 1 |
| Shi, J | 1 |
| Yang, G | 1 |
| Zhang, Z | 1 |
| Yang, K | 1 |
| Wang, J | 1 |
| Huang, Z | 1 |
| Yin, L | 1 |
| Guan, L | 1 |
| Li, Z | 1 |
| Tan, C | 1 |
| Hu, J | 1 |
| Gao, M | 1 |
| Zhang, Y | 2 |
| Wang, Y | 1 |
| Qiao, Z | 1 |
| Zhang, W | 1 |
| Wang, Q | 1 |
| Yan, L | 1 |
| Qian, H | 1 |
| Batista, DC | 1 |
| Silva, DPB | 1 |
| Florentino, IF | 1 |
| Cardoso, CS | 1 |
| Gonçalves, MP | 1 |
| Valadares, MC | 1 |
| Lião, LM | 1 |
| Sanz, G | 1 |
| Vaz, BG | 1 |
| Costa, EA | 1 |
| Menegatti, R | 1 |
| Cisar, JS | 1 |
| Weber, OD | 1 |
| Clapper, JR | 1 |
| Blankman, JL | 1 |
| Henry, CL | 1 |
| Simon, GM | 1 |
| Alexander, JP | 1 |
| Jones, TK | 1 |
| Ezekowitz, RAB | 1 |
| O'Neill, GP | 1 |
| Grice, CA | 1 |
| Kono, M | 2 |
| Matsumoto, T | 2 |
| Imaeda, T | 1 |
| Kawamura, T | 2 |
| Fujimoto, S | 1 |
| Kosugi, Y | 1 |
| Odani, T | 1 |
| Shimizu, Y | 1 |
| Matsui, H | 1 |
| Shimojo, M | 2 |
| Kori, M | 2 |
| Ahn, K | 1 |
| Johnson, DS | 1 |
| Mileni, M | 1 |
| Beidler, D | 1 |
| Long, JZ | 1 |
| McKinney, MK | 1 |
| Weerapana, E | 1 |
| Sadagopan, N | 1 |
| Liimatta, M | 1 |
| Smith, SE | 1 |
| Lazerwith, S | 1 |
| Stiff, C | 1 |
| Kamtekar, S | 1 |
| Bhattacharya, K | 1 |
| Swaney, S | 1 |
| Van Becelaere, K | 1 |
| Stevens, RC | 1 |
| Cravatt, BF | 1 |
| Biancalani, C | 1 |
| Giovannoni, MP | 1 |
| Pieretti, S | 1 |
| Cesari, N | 1 |
| Graziano, A | 1 |
| Vergelli, C | 1 |
| Cilibrizzi, A | 1 |
| Di Gianuario, A | 1 |
| Colucci, M | 1 |
| Mangano, G | 1 |
| Garrone, B | 1 |
| Polenzani, L | 1 |
| Dal Piaz, V | 1 |
| Nishimura, A | 1 |
| Kiyota, Y | 1 |
| Oki, H | 1 |
| Miyazaki, J | 1 |
| Igaki, S | 1 |
| Behnke, CA | 1 |
9 other studies available for piperazine and Ache
| Article | Year |
|---|---|
Development of indole-2-carbonyl piperazine urea derivatives as selective FAAH inhibitors for efficient treatment of depression and pain.
Topics: Amidohydrolases; Animals; Depression; Endocannabinoids; Enzyme Inhibitors; Heterocyclic Compounds; H | 2022 |
Novel piperazine-2,5-dione analogs bearing 1H-indole: Synthesis and biological effects.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; Antidepressive Agents; Depression; Drug Discovery; In | 2020 |
Novel piperazine urea derivatives as highly potent transient receptor potential vanilloid 1 (TRPV1) antagonists.
Topics: Analgesics; Animals; Capsaicin; Dose-Response Relationship, Drug; Humans; Male; Molecular Structure; | 2021 |
Anti-inflammatory effect of a new piperazine derivative: (4-methylpiperazin-1-yl)(1-phenyl-1H-pyrazol-4-yl)methanone.
Topics: Analgesics; Animals; Anti-Inflammatory Agents; BALB 3T3 Cells; Carrageenan; Cell Line; Cell Movement | 2018 |
Identification of ABX-1431, a Selective Inhibitor of Monoacylglycerol Lipase and Clinical Candidate for Treatment of Neurological Disorders.
Topics: Animals; Dogs; Dose-Response Relationship, Drug; Drug Discovery; Humans; Male; Mice; Molecular Targe | 2018 |
Design, synthesis, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase inhibitors.
Topics: Administration, Oral; Amidohydrolases; Analgesics; Animals; Brain; Disease Models, Animal; Drug Desi | 2014 |
Discovery and characterization of a highly selective FAAH inhibitor that reduces inflammatory pain.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain; Crystallography, X-Ray; Endocannabinoids; Enzyme | 2009 |
Further studies on arylpiperazinyl alkyl pyridazinones: discovery of an exceptionally potent, orally active, antinociceptive agent in thermally induced pain.
Topics: Administration, Oral; Analgesics; Animals; Cell Line; Drug Discovery; Hot Temperature; Humans; Male; | 2009 |
Synthesis, SAR study, and biological evaluation of a series of piperazine ureas as fatty acid amide hydrolase (FAAH) inhibitors.
Topics: Amidohydrolases; Analgesics; Animals; Humans; Mice; Molecular Docking Simulation; Pain; Piperazine; | 2013 |