Page last updated: 2024-08-23

piperacillin and Critical Illness

piperacillin has been researched along with Critical Illness in 111 studies

Research

Studies (111)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (0.90)	18.2507
2000's	7 (6.31)	29.6817
2010's	68 (61.26)	24.3611
2020's	35 (31.53)	2.80

Authors

Authors	Studies
Ariza, J; Dominguez, MA; Gudiol, F; Guzmán, A; Peña, C; Pujol, M; Suarez, C; Tubau, F	1
Abdul-Aziz, MH; Burrows, F; Buscher, H; Cheng, V; Cho, YJ; Corley, A; Diehl, A; Fraser, JF; Gilder, E; Jakob, SM; Kim, HS; Levkovich, BJ; Lim, SY; McGuinness, S; Parke, R; Pellegrino, V; Que, YA; Reynolds, C; Roberts, JA; Rudham, S; Shekar, K; Wallis, SC; Welch, SA; Zacharias, D	1
Colman, S; De Waele, JJ; Dhaese, S; Stove, V; Verstraete, AG	1
Burgess, DS; Clark, JA; Landmesser, KB	1
Bucher, V; Irlbeck, M; Liebchen, U; Paal, M; Scharf, C; Schroeder, I; Vogeser, M; Zoller, M	1
Agarwal, SK; Buckley, MS; D'Alessio, PA; Kane-Gill, SL; Kobic, E; Komerdelj, IA; Martinez, BK; Rangan, P; Tinta, NC; Yerondopoulos, MJ; Ziadat, DS	1
Besch, G; Capellier, G; Chaignat, C; Clairet, AL; Despres, C; Floury, SP; Labro, G; Lagoutte-Renosi, J; Montange, D; Piton, G; Puyraveau, M; Vettoretti, L; Vivet, B; Winiszewski, H	1
Chua, NG; Cove, M; Hee, DKH; Hoo, GSR; Kwa, AL; Lee, LS; Lee, W; Lim, TP; Ling, LM; Loo, L; Ng, TM; Ong, JCL; Soong, JL; Tang, SSL; Zhou, YP	1
Barreto, EF; Fugate, JE; Gajic, O; Haddad, NA; Hocker, SE; Ice, CJ; Leung, SB; Mara, KC; Rabinstein, AA; Rule, AD; Schreier, DJ	1
Kim, HI; Kim, HS; Kim, YK; Lee, DH; Lee, SH; Park, S	1
El-Haffaf, I; Guilhaumou, R; Marsot, A; Velly, L	2
Akers, KS; Chung, KK; DeLuca, JP; Livezey, JR; Nadeau, RJ; Por, ED; Pruskowski, KA; Selig, DJ	1
Butragueño-Laiseca, L; Campillo, N; Fernández, SN; García, X; Grau, S; Marco-Ariño, N; Padilla, B; Santiago, MJ; Slöcker, M; Troconiz, IF	1
Anane, S; Attou, R; Barreto Gutierrez, L; Cismas, BV; Djimafo, P; Gallerani, A; Honore, PM; Kaefer, K; Preseau, T; Redant, S	1
Liebchen, U; Scharf, C	1
Bazan, NS; Elmazar, MM; Naiim, CM; Sabri, NA	1
François, T; Luc, A; Novy, E; Pape, E; Scala-Bertola, J	1
Babiak, P; Cizmarova, I; Kovac, A; Mikus, P; Parrak, V; Piestansky, J; Secnik, P	1
Ankravs, MJ; Bellomo, R; Deane, AM; Rechnitzer, T; Roberts, JA; Sharrock, L; Wallis, SC	1
Aardema, H; Colin, P; De Corte, T; De Waele, JJ; Dhaese, SAM; Ongenae, F; Stove, V; Van Hoecke, S; Vander Mijnsbrugge, D; Verhaeghe, J; Verstraete, AG; Zijlstra, JG	1
Laramie, KE; Miller, MA; Mueller, SW; Roper, SE; Torian, SC; Wiktor, AJ	1
Jang, SM; Lewis, SJ; Rhie, SJ	1
Benaboud, S; Béranger, A; Berthaud, R; Bille, E; Bouazza, N; Foissac, F; Gana, I; Lesage, F; Oualha, M; Renolleau, S; Thy, M; Toubiana, J; Tréluyer, JM; Urien, S	1
Béranger, A; Bille, E; Callot, D; Chouchana, L; Debray, A; Hirt, D; Oualha, M; Renolleau, S; Tréluyer, JM	1
Chai, MG; Cotta, MO; Farkas, A; Roberts, JA	1
Armengol de la Hoz, MÁ; Becker, CD; Calvachi-Prieto, P; Celi, LA; Chen, AY; Chen, C; Dagan, A; Deng, CY; Johnson, AEW; Khazi-Syed, A; Scurlock, C	1
Cotta, MO; Elhadi, M; Farkas, A; Imani, S; Kanji, S; Luque-Pardos, S; Roberts, JA; Sanches, C; Sandaradura, I; Scheetz, MH; Schellack, N; Tabah, A; Timsit, JF; Wilks, K; Williams, PG; Xie, J	1
Arriaga-García, FJ; Medellín-Garibay, SE; Milán-Segovia, RDC; Pérez-González, LF; Rodríguez-Báez, AS; Romano-Moreno, S; Velarde-Salcedo, R	1
Bertsch, T; Heilmann, M; Höhl, R; Kleine, FM; Koch, S; Liebchen, U; Paal, M; Schuster, C; Steinmann, J; Vogeser, M	1
Kächele, M; Keller, F	1
Agbeve, J; Baptista, JP; Bekos, V; Bellomo, R; Boidin, C; Brinkmann, A; Buizen, L; Castro, P; Choi, G; Cole, CL; Creteur, J; De Waele, JJ; Deans, R; Eastwood, GM; Escobar, L; Gomersall, C; Gresham, R; Jamal, JA; Joynt, GM; Kanji, S; Kluge, S; König, C; Koulouras, VP; Lassig-Smith, M; Laterre, PF; Lee, A; Lefrant, JY; Lei, K; Leung, P; Lipman, J; Llauradó-Serra, M; Martin-Loeches, I; Mat Nor, MB; Mudaliar, MY; Ostermann, M; Parker, SL; Paul, SK; Peake, SL; Rello, J; Richards, B; Roberts, DM; Roberts, JA; Roberts, MS; Rodríguez, A; Roehr, AC; Roger, C; Seoane, L; Sinnollareddy, M; Sousa, E; Soy, D; Spring, A; Starr, T; Stephens, D; Taccone, FS; Thomas, J; Turnidge, J; Ulldemolins, M; Valkonen, MM; Wallis, SC; Williams, T; Wittebole, X; Zikou, XT	1
Benaboud, S; Béranger, A; Gana, I; Hirt, D; Lesage, F; Nguyen-Khoa, T; Oualha, M; Renolleau, S; Toubiana, J; Tréluyer, JM; Urien, S; Zheng, Y	1
Grabein, B; Liebchen, U; Paal, M; Scharf, C; Schroeder, I; Siebers, C; Zander, J; Zoller, M	1
Benken, LA; Chamberlain, AR; Jones, RL; Kaplan, JM; Murphy, ME; Stoneman, EM; Tang Girdwood, SC; Tang, PH; Vinks, AA	1
Caissy, JA; El-Haffaf, I; Marsot, A	1
Carlier, M; De Cock, PAJG; de Jaeger, A; De Paepe, P; Delanghe, JR; Della Pasqua, OE; Robays, H; van Dijkman, SC; Vande Walle, J; Verstraete, AG; Willems, J	1
Chan, JD; Dellit, TH; Lynch, JB	1
Aardema, H; Alffenaar, JW; Dieperink, W; Kosterink, JGW; Nannan Panday, P; van Hateren, K; Wessels, M; Zijlstra, JG	1
Cotta, MO; Lefrant, JY; Lipman, J; Muller, L; Roberts, JA; Roger, C; Wallis, SC	1
Bennis, Y; Bodeau, S; Kontar, L; Lemaire-Hurtel, AS; Maizel, J; Masmoudi, K; Quinton, MC; Slama, M; Zerbib, Y	1
Mueller, BA; Shaw, AR	1
Fusco, NM; Hassinger, AB; Holsen, MR; Meaney, CJ	1
Awdishu, L	1
Guerra Valero, YC; Lipman, J; Naicker, S; Ordenez Meija, JL; Parker, SL; Roberts, JA; Wallis, SC	1
Beckman, EJ	1
Boselli, E; Felton, TW; Hope, WW; Ogungbenro, K; Rodvold, KA	1
Lipman, J; Peake, SL; Roberts, JA; Roberts, MS; Sinnollareddy, MG	1
Alobaid, A; Hiremath, S; Kanji, S; Patel, R; Porteous, R; Roberts, JA; Watpool, I; Xie, J; Zelenitsky, S; Zhang, G	1
Benaboud, S; Béranger, A; Bille, E; Gana, I; Genuini, M; Hirt, D; Lesage, F; Moulin, F; Oualha, M; Renolleau, S; Tréluyer, JM; Urien, S; Zheng, Y	1
Farkas, A; Heil, EL; Nicolau, DP; Roberts, JA; Thom, KA	1
Keller, F	1
Biais, M; Breilh, D; Carrié, C; Rubin, S; Sioniac, P	1
Ally, M; Briscoe, S; Lipman, J; McWhinney, B; Roberts, JA; Ungerer, J; Wong, G	1
Colman, S; De Waele, JJ; Stove, V; Verstraete, AG	1
Blevins, AM; Juang, P; Kollef, M; Lashinsky, JN; McCammon, C; Micek, S	1
Juang, P; Kollef, MH; Micek, ST	1
Damen, C; De Waele, JJ; Dhaese, S; Stove, V; Verstraete, AG	1
Adnan, S; Jarrett, P; Li, JX; Lipman, J; Paterson, DL; Roberts, JA; Rudd, M; Udy, AA; Wallis, SC	1
Carlier, M; Carrette, S; De Waele, JJ; Decruyenaere, J; Depuydt, P; Hoste, E; Lipman, J; Roberts, JA; Stove, V; Verstraete, A; Wallis, SC	1
Kollef, MH	1
Allen, N; Fish, DN; Newell, M; Rafferty, KD; Sturm, AW; Toschlog, E; Waibel, B	1
Cies, JJ; Kuti, JL; Schlichting, C; Shankar, V	1
Asín-Prieto, E; Isla, A; Maynar, J; Rodríguez-Gascón, A; Sánchez-Izquierdo, JÁ; Soraluce, A; Trocóniz, IF	1
Althaus, K; Busemann, C; Friesecke, S; Greinacher, A; Hron, G; Knutson, F; Lubenow, N; Thiele, T	1
Boelens, J; Carlier, M; Carrette, S; Claeys, G; De Waele, JJ; Decruyenaere, J; Depuydt, P; Hoste, E; Leroux-Roels, I; Stove, V; Verstraete, AG	1
Boots, RJ; Jarrett, P; Kirkpatrick, CM; Lipman, J; Roberts, JA; Varghese, JM	1
Jamal, JA; Lipman, J; Roberts, JA; Udy, AA	1
Carlier, M; Carrette, S; De Waele, JJ; Stove, V; Verstraete, AG	1
Akers, KS; Cannon, JW; Chung, KK; Cota, JM; Murray, CK; Niece, KL	1
Boselli, E; Felton, TW; Hope, WW; Lodise, TP; Neely, MN; Roberts, JA; Van Guilder, M	1
Bentley, AM; Felton, TW; Goodwin, J; Hope, WW; Isalska, B; Malagon, I; McCalman, K; Whalley, S	1
Calvo, G; Llauradó-Serra, M; Martín-Loeches, I; Pontes, C; Soy, D; Ulldemolins, M; Vaquer, S	1
Piérard, D; Spapen, H; Yusuf, E	1
Andersen, MH; Arendrup, MC; Bestle, MH; Cozzi-Lepri, A; Drenck, NE; Grarup, J; Hein, L; Helweg-Larsen, J; Jensen, JU; Johansen, ME; Larsen, KM; Lauritsen, AØ; Lundgren, B; Lundgren, JD; Løken, J; Mohr, T; Møller, JK; Olesen, B; Petersen, JA; Reinholdt, K; Strange, D; Søe-Jensen, P; Thormar, K; Tousi, H; Østergaard, C	1
Jarrett, P; Kirkpatrick, CM; Klein, K; Kruger, PS; Lipman, J; Patel, K; Paterson, DL; Roberts, JA; Roberts, MS; Udy, AA; Wallis, SC	1
Allou, N; Allyn, J; Augustin, P; Desmard, M; Kortbaoui, R; Lucet, JC; Montravers, P; Snauwaert, A; Welsch, C	1
Jamal, JA; Lipman, J; Mat-Nor, MB; Mohamad-Nor, FS; Roberts, DM; Roberts, JA; Udy, AA; Wallis, SC	1
Amyot, J; Awissi, DK; Beauchamp, A; Fagnan, M; Hébert, E; Lavallée, C; Lavigne, V; Leblanc, M; Lebrun, G; Munoz, DL; Pichette, V; Robitaille, R; Savoie, M; Tétreault, N; Varin, F	1
Abdul-Aziz, MH; Akova, M; Bassetti, M; De Waele, JJ; Dimopoulos, G; Dulhunty, J; Kaukonen, KM; Koulenti, D; Lipman, J; Martin, C; Montravers, P; Rello, J; Rhodes, A; Roberts, JA; Starr, T; Wallis, SC	1
Davies, SW; Dietch, ZC; Efird, JT; Guidry, CA; Sawyer, RG; Shah, PM; Willis, RN	1
Buenger, LE; Chung, EK; Crumby, AS; Dees, J; Healy, DP; Kays, MB; Knoderer, CA; Nichols, K	1
Bezouška, J; Havel, E; Kaška, M; Malbrain, ML; Martínková, J; Šafránek, P	1
Cotton, F; Creteur, J; Gustot, T; Hites, M; Jacobs, F; Lheureux, O; Surin, R; Taccone, FS; Trepo, E; Vincent, JL; Wolff, F	1
Abdul-Aziz, MH; Alobaid, AS; Brinkmann, A; Frey, OR; Grau, S; Lipman, J; Luque, S; Roberts, JA; Roberts, MS; Roehr, AC; Wong, G	1
Calvo, G; Fernández, J; Llauradó-Serra, M; Martín-Loeches, I; Pontes, C; Rodríguez, A; Soy, D; Torres, A; Ulldemolins, M; Vaquer, S	1
Hammond, DA; Lusardi, K; Meena, NK; Painter, JT; Smith, MN	1
Döbbeler, G; Frey, L; Huseyn-Zada, M; Jung, J; Maier, B; Nagel, D; Scharf, C; Vogeser, M; Zander, J; Zoller, M	1
Cotta, MO; Lipman, J; Little, PJ; McDonald, C; McWhinney, B; Roberts, JA; Ungerer, JP	1
Aduroja, OA; Amde, M; Connor, MJ; Fissell, WH; Gould, ER; Groszek, JJ; Madonia, PN; Nesbitt, R; Salem, C; Shotwell, MS; Taylor, ME; Tolwani, AJ; Wei, P	1
Bergen, PJ; Bulitta, JB; Kirkpatrick, CM; Landersdorfer, CB; Lipman, J; McGregor, MJ; Paterson, DL; Roberts, JA; Rogers, KE; Wallis, SC	1
Cotta, MO; Lipman, J; Roberts, JA	1
Döbbeler, G; Frey, L; Huseyn-Zada, M; Jung, J; Nagel, D; Scharf, C; Vogeser, M; Zander, J; Zoller, M	1
Bao, H; Lv, Y; Wang, D; Xue, J; Yan, Z	1
Chan, YH; Cheng, WY; Fan, SY; Leung, SM; Shum, HP; Yan, WW	1
Breilh, D; Jaber, S; Jean-Pierre, H; Jung, B; Legeron, R; Mahul, M; Molinari, N; Signe, J; Uhlemann, AC	1
Alquezar, A; Castro, P; Codina, C; Delgado, E; Marco, F; Martí, S; Martínez, JA; Mensa, J; Nicolás, JM; Soriano, A; Torres, A; Trilla, A; Vila, J	1
Dalley, AJ; Lipman, J; Roberts, JA; Roberts, MS; Robertson, TA	1
Dalley, AJ; Kirkpatrick, CM; Lipman, J; Roberts, JA; Roberts, MS	1
Blondiaux, N; Courcol, RJ; Durocher, A; Favory, R; Nseir, S; Onimus, T; Roussel-Delvallez, M; Wallet, F	1
Gonçalves-Pereira, J; Póvoa, P	1
Delattre, IK; Jacobs, F; Jacqmin, P; Laterre, PF; Musuamba, FT; Taccone, FS; Verbeeck, RK; Wallemacq, P	1
Bellomo, R; Cole, L; Lipman, J; Liu, X; Nair, P; Roberts, DM; Roberts, JA; Roberts, MS	1
Bento, L; Estilita, J; Gonçalves-Pereira, J; Gouveia, J; Janeiro, S; Monteiro, C; Oliveira, BS; Paulino, C; Póvoa, P; Salgueiro, A; Vieira, A	1
Lee, GC; Liou, H; Neldner, K; Quan, CF; Yee, R	1
Fissell, WH	1
Brunner, M; Erovic, BM; Georgopoulos, A; Joukhadar, C; Marsik, C; Müller, M; Sauermann, R; Zeitlinger, M	1
Fazeli, MR; Gholami, K; Mojtahedzadeh, M; Najafi, A; Rafati, MR; Rouini, MR; Tavakoli, H	1
Drusano, GL; Lodise, TP; Lomaestro, B	1
Cross, SE; Lipman, J; Roberts, JA; Roberts, MS; Robertson, TA	1
Barale, F; Blasco, G; Boillot, A; Capellier, G; Cornette, C; Guinchard, C; Jacques, T	1

Reviews

10 review(s) available for piperacillin and Critical Illness

Article	Year
Pharmacokinetics of piperacillin and tazobactam in critically Ill patients treated with continuous kidney replacement therapy: A mini-review and population pharmacokinetic analysis. Journal of clinical pharmacy and therapeutics, 2022, Volume: 47, Issue:8 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Renal Replacement Therapy; Tazobactam	2022
[Pharmacokinetics and pharmacodynamics in extracorporeal renal replacement therapy]. Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2021, Volume: 116, Issue:4 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Meropenem; Piperacillin; Renal Dialysis; Renal Replacement Therapy; Vancomycin	2021
Piperacillin-Tazobactam in Intensive Care Units: A Review of Population Pharmacokinetic Analyses. Clinical pharmacokinetics, 2021, Volume: 60, Issue:7 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Intensive Care Units; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Prospective Studies; Tazobactam	2021
Antibiotic Dosing in Continuous Renal Replacement Therapy. Advances in chronic kidney disease, 2017, Volume: 24, Issue:4 Topics: Anti-Bacterial Agents; Cefepime; Ceftazidime; Cephalosporins; Computer Simulation; Critical Illness; Humans; Levofloxacin; Meropenem; Microbial Sensitivity Tests; Monte Carlo Method; Penicillanic Acid; Piperacillin; Renal Replacement Therapy; Sepsis; Tazobactam; Thienamycins	2017
Drug-induced kidney disease in the ICU: mechanisms, susceptibility, diagnosis and management strategies. Current opinion in critical care, 2017, Volume: 23, Issue:6 Topics: Acute Kidney Injury; Critical Illness; Disease Susceptibility; Drug Therapy, Combination; Humans; Intensive Care Units; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Practice Guidelines as Topic; Renal Replacement Therapy; Risk Factors; Vancomycin	2017
[Pharmacotherapy and kidney dysfunction]. Medizinische Klinik, Intensivmedizin und Notfallmedizin, 2019, Volume: 114, Issue:5 Topics: Anti-Bacterial Agents; Critical Illness; Glomerular Filtration Rate; Humans; Kidney Diseases; Meropenem; Pharmacokinetics; Piperacillin; Vancomycin	2019
Beta-lactam dosing in critically ill patients with septic shock and continuous renal replacement therapy. Critical care (London, England), 2014, Jun-23, Volume: 18, Issue:3 Topics: Anti-Bacterial Agents; beta-Lactams; Ceftriaxone; Critical Illness; Humans; Meropenem; Piperacillin; Renal Replacement Therapy; Shock, Septic; Thienamycins	2014
Prolonged vs intermittent infusion of piperacillin/tazobactam in critically ill patients: a narrative and systematic review. Journal of critical care, 2014, Volume: 29, Issue:6 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Critical Illness; Female; Humans; Infusions, Intravenous; Length of Stay; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Randomized Controlled Trials as Topic; Retrospective Studies	2014
Antibiotics in critically ill patients: a systematic review of the pharmacokinetics of β-lactams. Critical care (London, England), 2011, Volume: 15, Issue:5 Topics: Anti-Bacterial Agents; beta-Lactams; Cefepime; Cefpirome; Ceftazidime; Cephalosporins; Critical Illness; Humans; Imipenem; Infections; Meropenem; Piperacillin; Thienamycins	2011
Antimicrobial dosing in acute renal replacement. Advances in chronic kidney disease, 2013, Volume: 20, Issue:1 Topics: Acute Kidney Injury; Anti-Bacterial Agents; Antifungal Agents; Biological Availability; Critical Care; Critical Illness; Drug Administration Schedule; Drug Dosage Calculations; Humans; Inactivation, Metabolic; Metabolic Clearance Rate; Piperacillin; Practice Guidelines as Topic; Renal Replacement Therapy; Tissue Distribution	2013

Trials

10 trial(s) available for piperacillin and Critical Illness

Article	Year
Extended infusion of piperacillin-tazobactam versus intermittent infusion in critically ill egyptian patients: a cost-effectiveness study. Scientific reports, 2022, 06-27, Volume: 12, Issue:1 Topics: Anti-Bacterial Agents; Cost-Benefit Analysis; Critical Illness; Egypt; Gram-Negative Bacterial Infections; Humans; Infusions, Intravenous; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies	2022
Population pharmacokinetics of piperacillin and tazobactam in critically ill patients undergoing continuous renal replacement therapy: application to pharmacokinetic/pharmacodynamic analysis. The Journal of antimicrobial chemotherapy, 2014, Volume: 69, Issue:1 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Critical Illness; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Renal Replacement Therapy; Serum; Young Adult	2014
Therapeutic drug monitoring-based dose optimisation of piperacillin and meropenem: a randomised controlled trial. Intensive care medicine, 2014, Volume: 40, Issue:3 Topics: beta-Lactamase Inhibitors; Creatine; Critical Illness; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Male; Meropenem; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Thienamycins	2014
Pulmonary penetration of piperacillin and tazobactam in critically ill patients. Clinical pharmacology and therapeutics, 2014, Volume: 96, Issue:4 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Critical Illness; Drug Combinations; Drug Resistance, Bacterial; Female; Humans; Lung; Male; Middle Aged; Monte Carlo Method; Penicillanic Acid; Permeability; Piperacillin; Tazobactam	2014
Invasive Candida infections and the harm from antibacterial drugs in critically ill patients: data from a randomized, controlled trial to determine the role of ciprofloxacin, piperacillin-tazobactam, meropenem, and cefuroxime. Critical care medicine, 2015, Volume: 43, Issue:3 Topics: Age Factors; Aged; Anti-Bacterial Agents; APACHE; Candidiasis, Invasive; Cefuroxime; Ciprofloxacin; Critical Illness; Denmark; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Intensive Care Units; Male; Meropenem; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Single-Blind Method; Thienamycins	2015
Pharmacokinetics of piperacillin in critically ill patients receiving continuous venovenous haemofiltration: A randomised controlled trial of continuous infusion versus intermittent bolus administration. International journal of antimicrobial agents, 2015, Volume: 46, Issue:1 Topics: Administration, Intravenous; Adult; Aged; Anti-Bacterial Agents; Blood Chemical Analysis; Critical Illness; Female; Hemofiltration; Humans; Male; Metabolic Clearance Rate; Microbial Sensitivity Tests; Middle Aged; Piperacillin; Prospective Studies; Sepsis	2015
Clinical outcomes of extended versus intermittent administration of piperacillin/tazobactam for the treatment of hospital-acquired pneumonia: a randomized controlled trial. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2017, Volume: 36, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactamase Inhibitors; China; Chromatography, High Pressure Liquid; Costs and Cost Analysis; Critical Illness; Cross Infection; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Plasma; Pneumonia, Bacterial; Treatment Outcome; Young Adult	2017
Piperacillin penetration into tissue of critically ill patients with sepsis--bolus versus continuous administration? Critical care medicine, 2009, Volume: 37, Issue:3 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Critical Illness; Female; Humans; Male; Piperacillin; Prospective Studies; Sepsis; Tissue Distribution; Young Adult	2009
Population pharmacokinetics of four β-lactams in critically ill septic patients comedicated with amikacin. Clinical biochemistry, 2012, Volume: 45, Issue:10-11 Topics: Adult; Aged; Aged, 80 and over; Algorithms; Amikacin; Anti-Bacterial Agents; beta-Lactams; Cefepime; Ceftazidime; Cephalosporins; Critical Illness; Drug Monitoring; Female; Humans; Male; Meropenem; Metabolic Clearance Rate; Middle Aged; Models, Biological; Piperacillin; Sepsis; Thienamycins; Tissue Distribution; Treatment Outcome	2012
Clinical efficacy of continuous infusion of piperacillin compared with intermittent dosing in septic critically ill patients. International journal of antimicrobial agents, 2006, Volume: 28, Issue:2 Topics: Adult; Aged; Anti-Bacterial Agents; APACHE; Critical Illness; Drug Administration Schedule; Female; Gram-Negative Bacteria; Gram-Negative Bacterial Infections; Humans; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Middle Aged; Piperacillin; Sepsis; Severity of Illness Index; Treatment Outcome	2006

Other Studies

91 other study(ies) available for piperacillin and Critical Illness

Article	Year
Effects of carbapenem exposure on the risk for digestive tract carriage of intensive care unit-endemic carbapenem-resistant Pseudomonas aeruginosa strains in critically ill patients. Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:6 Topics: Adult; Aged; Anti-Bacterial Agents; beta-Lactam Resistance; Carbapenems; Carrier State; Critical Illness; Endemic Diseases; Female; Gastrointestinal Tract; Humans; Imipenem; Incidence; Intensive Care Units; Male; Middle Aged; Pharynx; Pseudomonas aeruginosa; Pseudomonas Infections; Rectum; Risk Factors	2007
Population Pharmacokinetics of Piperacillin and Tazobactam in Critically Ill Patients Receiving Extracorporeal Membrane Oxygenation: an ASAP ECMO Study. Antimicrobial agents and chemotherapy, 2021, 10-18, Volume: 65, Issue:11 Topics: Anti-Bacterial Agents; Critical Illness; Extracorporeal Membrane Oxygenation; Humans; Piperacillin; Tazobactam	2021
Pilot study of oral fluid and plasma meropenem and piperacillin concentrations in the intensive care unit. Clinica chimica acta; international journal of clinical chemistry, 2021, Volume: 523 Topics: Adult; Aged; Anti-Bacterial Agents; Critical Illness; Humans; Intensive Care Units; Meropenem; Middle Aged; Pilot Projects; Piperacillin; Young Adult	2021
Time Above All Else: Pharmacodynamic Analysis of β-Lactams in Critically Ill Patients. Journal of clinical pharmacology, 2022, Volume: 62, Issue:4 Topics: Anti-Bacterial Agents; beta-Lactams; Cefepime; Critical Illness; Humans; Meropenem; Microbial Sensitivity Tests; Monte Carlo Method; Piperacillin; Pseudomonas aeruginosa; Tazobactam	2022
Trough concentrations of meropenem and piperacillin during slow extended dialysis in critically ill patients with intermittent and continuous infusion: A prospective observational study. Journal of critical care, 2022, Volume: 67 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Meropenem; Piperacillin; Renal Dialysis	2022
Vancomycin with concomitant piperacillin/tazobactam vs. cefepime or meropenem associated acute kidney injury in the critically ill: A multicenter propensity score-matched study. Journal of critical care, 2022, Volume: 67 Topics: Acute Kidney Injury; Adult; Anti-Bacterial Agents; Cefepime; Cohort Studies; Critical Illness; Drug Therapy, Combination; Humans; Meropenem; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Propensity Score; Retrospective Studies; Vancomycin	2022
β-lactam dosing at the early phase of sepsis: Performance of a pragmatic protocol for target concentration achievement in a prospective cohort study. Journal of critical care, 2022, Volume: 67 Topics: Anti-Bacterial Agents; beta-Lactams; Critical Illness; Humans; Meropenem; Piperacillin; Prospective Studies; Sepsis	2022
Therapeutic drug monitoring of meropenem and piperacillin-tazobactam in the Singapore critically ill population - A prospective, multi-center, observational study (BLAST 1). Journal of critical care, 2022, Volume: 68 Topics: Adult; Anti-Bacterial Agents; beta-Lactams; Critical Illness; Drug Monitoring; Humans; Meropenem; Microbial Sensitivity Tests; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Singapore	2022
Incidence and Predictive Factors Associated with Beta-Lactam Neurotoxicity in the Critically Ill: A Retrospective Cohort Study. Neurocritical care, 2022, Volume: 37, Issue:1 Topics: Adult; Anti-Bacterial Agents; beta-Lactams; Cohort Studies; Critical Illness; Humans; Incidence; Piperacillin; Retrospective Studies	2022
Population pharmacokinetics of piperacillin/tazobactam in critically ill Korean patients and the effects of extracorporeal membrane oxygenation. The Journal of antimicrobial chemotherapy, 2022, 04-27, Volume: 77, Issue:5 Topics: Adult; Anti-Bacterial Agents; Critical Illness; Extracorporeal Membrane Oxygenation; Humans; Microbial Sensitivity Tests; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Republic of Korea; Tazobactam	2022
Using a Validated Population Pharmacokinetic Model for Dosing Recommendations of Continuous Infusion Piperacillin for Critically Ill Adult Patients. Clinical pharmacokinetics, 2022, Volume: 61, Issue:6 Topics: Adult; Anti-Bacterial Agents; Critical Illness; Humans; Intensive Care Units; Microbial Sensitivity Tests; Piperacillin	2022
Population pharmacokinetics of piperacillin in critically ill children including those undergoing continuous kidney replacement therapy. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases, 2022, Volume: 28, Issue:9 Topics: Anti-Bacterial Agents; Child; Critical Illness; Humans; Microbial Sensitivity Tests; Piperacillin; Piperacillin, Tazobactam Drug Combination; Renal Replacement Therapy	2022
Letter to the editor: "Trough concentrations of meropenem and piperacillin during slow extended dialysis in critically ill patients with intermittent and continuous infusion: A prospective observational study". Journal of critical care, 2022, Volume: 70 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Infusions, Intravenous; Meropenem; Piperacillin; Renal Dialysis; Thienamycins	2022
Authors response: "Trough concentrations of meropenem and piperacillin during slow extended dialysis in critically ill patients with intermittent and continuous infusion: A prospective observational study". Journal of critical care, 2022, Volume: 70 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Infusions, Intravenous; Meropenem; Piperacillin; Renal Dialysis; Thienamycins	2022
Is therapeutic drug monitoring really helpful for managing piperacillin/tazobactam therapy in critically ill patients? Intensive care medicine, 2022, Volume: 48, Issue:11 Topics: Anti-Bacterial Agents; Critical Illness; Drug Monitoring; Humans; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination	2022
An Ultra-High-Performance Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Determination of 4 β-Lactam Antibiotics, Tazobactam, and Linezolid in Human Plasma Samples. Therapeutic drug monitoring, 2022, 12-01, Volume: 44, Issue:6 Topics: Anti-Bacterial Agents; Cefepime; Cefotaxime; Chromatography, High Pressure Liquid; Critical Illness; Drug Monitoring; Humans; Linezolid; Meropenem; Monobactams; Piperacillin; Reproducibility of Results; Tandem Mass Spectrometry; Tazobactam	2022
Clearance of Piperacillin-Tazobactam and Vancomycin During Continuous Renal Replacement With Regional Citrate Anticoagulation. Therapeutic drug monitoring, 2023, 04-01, Volume: 45, Issue:2 Topics: Acute Kidney Injury; Anti-Bacterial Agents; Anticoagulants; Citrates; Citric Acid; Critical Illness; Humans; Piperacillin; Piperacillin, Tazobactam Drug Combination; Tazobactam; Vancomycin	2023
Development and evaluation of uncertainty quantifying machine learning models to predict piperacillin plasma concentrations in critically ill patients. BMC medical informatics and decision making, 2022, 08-25, Volume: 22, Issue:1 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Machine Learning; Piperacillin; Piperacillin, Tazobactam Drug Combination; Uncertainty	2022
Burn Injury and Augmented Renal Clearance: A Case for Optimized Piperacillin-Tazobactam Dosing. Journal of burn care & research : official publication of the American Burn Association, 2023, 01-05, Volume: 44, Issue:1 Topics: Anti-Bacterial Agents; Burns; Critical Illness; Humans; Microbial Sensitivity Tests; Piperacillin; Piperacillin, Tazobactam Drug Combination; Tazobactam	2023
Optimal antipseudomonal ꞵ-lactam drug dosing recommendations in critically-ill Asian patients receiving CRRT. Journal of critical care, 2022, Volume: 72 Topics: Anti-Bacterial Agents; Body Weight; Cefepime; Ceftazidime; Critical Illness; Humans; Lactams; Meropenem; Microbial Sensitivity Tests; Piperacillin; Piperacillin, Tazobactam Drug Combination	2022
Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children Receiving Continuous Renal Replacement Therapy. Antimicrobial agents and chemotherapy, 2022, 12-20, Volume: 66, Issue:12 Topics: Anti-Bacterial Agents; Child; Child, Preschool; Continuous Renal Replacement Therapy; Critical Illness; Humans; Piperacillin; Piperacillin, Tazobactam Drug Combination; Renal Replacement Therapy	2022
Beta-lactam exposure and safety in intermittent or continuous infusion in critically ill children: an observational monocenter study. European journal of pediatrics, 2023, Volume: 182, Issue:3 Topics: Anti-Bacterial Agents; Bayes Theorem; beta-Lactams; Cefotaxime; Child; Critical Illness; Humans; Infusions, Intravenous; Meropenem; Piperacillin; Prospective Studies	2023
Impact of piperacillin unbound fraction variability on dosing recommendations in critically ill patients. British journal of clinical pharmacology, 2023, Volume: 89, Issue:4 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Microbial Sensitivity Tests; Piperacillin; Piperacillin, Tazobactam Drug Combination	2023
Accuracy of a precision dosing software program for predicting antibiotic concentrations in critically ill patients. The Journal of antimicrobial chemotherapy, 2023, 02-01, Volume: 78, Issue:2 Topics: Anti-Bacterial Agents; Critical Illness; Drug Monitoring; Humans; Meropenem; Piperacillin; Sepsis; Software; Vancomycin	2023
A Large-Scale Multicenter Retrospective Study on Nephrotoxicity Associated With Empiric Broad-Spectrum Antibiotics in Critically Ill Patients. Chest, 2023, Volume: 164, Issue:2 Topics: Acute Kidney Injury; Anti-Bacterial Agents; Cefepime; Critical Illness; Drug Therapy, Combination; Humans; Meropenem; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies; Vancomycin	2023
International survey of antibiotic dosing and monitoring in adult intensive care units. Critical care (London, England), 2023, 06-19, Volume: 27, Issue:1 Topics: Adult; Aminoglycosides; Anti-Bacterial Agents; Critical Illness; Cross-Sectional Studies; Humans; Intensive Care Units; Meropenem; Piperacillin; Piperacillin, Tazobactam Drug Combination; Surveys and Questionnaires; Vancomycin	2023
Model-informed precision dosing of antimicrobial drugs in pediatrics: experiences from a pilot scale program. European journal of pediatrics, 2023, Volume: 182, Issue:9 Topics: Anti-Bacterial Agents; Bayes Theorem; Child; Clindamycin; Critical Illness; Fluconazole; Humans; Linezolid; Meropenem; Metronidazole; Neoplasms; Piperacillin; Vancomycin	2023
Comparative LC-MS/MS and HPLC-UV Analyses of Meropenem and Piperacillin in Critically Ill Patients. Clinical laboratory, 2019, Sep-01, Volume: 65, Issue:9 Topics: Anti-Bacterial Agents; Chromatography, High Pressure Liquid; Chromatography, Liquid; Critical Care; Critical Illness; Drug Monitoring; Humans; Meropenem; Piperacillin; Reproducibility of Results; Tandem Mass Spectrometry; Ultraviolet Rays	2019
The Effect of Renal Replacement Therapy and Antibiotic Dose on Antibiotic Concentrations in Critically Ill Patients: Data From the Multinational Sampling Antibiotics in Renal Replacement Therapy Study. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2021, 04-26, Volume: 72, Issue:8 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Meropenem; Piperacillin; Prospective Studies; Renal Replacement Therapy	2021
Estimation of piperacillin clearance with different glomerular filtration rate formulas in critically ill children. British journal of clinical pharmacology, 2021, Volume: 87, Issue:3 Topics: Adolescent; Adult; Child; Child, Preschool; Creatinine; Critical Illness; Glomerular Filtration Rate; Humans; Infant; Kidney Function Tests; Piperacillin; Young Adult	2021
The ONTAI study - a survey on antimicrobial dosing and the practice of therapeutic drug monitoring in German intensive care units. Journal of critical care, 2020, Volume: 60 Topics: Anti-Bacterial Agents; Critical Care; Critical Illness; Cross-Sectional Studies; Drug Monitoring; Germany; Humans; Intensive Care Units; Meropenem; Microbial Sensitivity Tests; Physicians; Piperacillin; Surveys and Questionnaires; Treatment Outcome; Vancomycin	2020
Demonstrating Feasibility of an Opportunistic Sampling Approach for Pharmacokinetic Studies of β-Lactam Antibiotics in Critically Ill Children. Journal of clinical pharmacology, 2021, Volume: 61, Issue:4 Topics: Adolescent; Anti-Bacterial Agents; beta-Lactams; Cefepime; Child; Child, Preschool; Comorbidity; Critical Illness; Feasibility Studies; Female; Humans; Intensive Care Units, Pediatric; Male; Meropenem; Piperacillin; Prospective Studies	2021
Dose optimization of piperacillin/tazobactam in critically ill children. The Journal of antimicrobial chemotherapy, 2017, 07-01, Volume: 72, Issue:7 Topics: Adolescent; Anti-Bacterial Agents; Bacterial Infections; Child; Child, Preschool; Critical Illness; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infant; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Monte Carlo Method; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Tazobactam	2017
Hospital Length of Stay Among Patients Receiving Intermittent Versus Prolonged Piperacillin/Tazobactam Infusion in the Intensive Care Units. Journal of intensive care medicine, 2018, Volume: 33, Issue:2 Topics: Aged; Anti-Bacterial Agents; Bacterial Infections; Critical Illness; Female; Hospital Mortality; Humans; Infusions, Intravenous; Intensive Care Units; Length of Stay; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies	2018
Target attainment with continuous dosing of piperacillin/tazobactam in critical illness: a prospective observational study. International journal of antimicrobial agents, 2017, Volume: 50, Issue:1 Topics: Adult; Aged; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Chromatography, Liquid; Critical Illness; Female; Humans; Male; Middle Aged; Netherlands; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Plasma; Prospective Studies; Tandem Mass Spectrometry; Young Adult	2017
Impact of renal replacement modalities on the clearance of piperacillin-tazobactam administered via continuous infusion in critically ill patients. International journal of antimicrobial agents, 2017, Volume: 50, Issue:2 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Chromatography; Critical Illness; Female; Hemofiltration; Humans; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Plasma; Prospective Studies; Renal Insufficiency; Time Factors	2017
Neurotoxic Concentration of Piperacillin during Continuous Infusion in Critically Ill Patients. Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:9 Topics: Aged; Anti-Bacterial Agents; Critical Care; Critical Illness; Drug Monitoring; Enterobacteriaceae; Enterobacteriaceae Infections; Female; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Nervous System Diseases; Penicillanic Acid; Piperacillin; Retrospective Studies; Tazobactam	2017
Increased Risk of Acute Kidney Injury in Critically Ill Children Treated With Vancomycin and Piperacillin/Tazobactam. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2017, Volume: 18, Issue:12 Topics: Acute Kidney Injury; Adolescent; Anti-Bacterial Agents; Ceftriaxone; Child; Child, Preschool; Critical Illness; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Infant; Intensive Care Units, Pediatric; Logistic Models; Male; Odds Ratio; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies; Vancomycin	2017
A UHPLC-MS/MS method for the simultaneous determination of piperacillin and tazobactam in plasma (total and unbound), urine and renal replacement therapy effluent. Journal of pharmaceutical and biomedical analysis, 2018, Jan-30, Volume: 148 Topics: Calibration; Chromatography, High Pressure Liquid; Critical Illness; Humans; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Plasma; Renal Replacement Therapy; Sensitivity and Specificity; Tandem Mass Spectrometry; Tazobactam; Urine	2018
Piperacillin-Tazobactam Plus Vancomycin Equals Acute Kidney Injury: Does It Add Up? Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies, 2017, Volume: 18, Issue:12 Topics: Acute Kidney Injury; Child; Critical Illness; Humans; Piperacillin; Tazobactam; Vancomycin	2017
Comparison of piperacillin exposure in the lungs of critically ill patients and healthy volunteers. The Journal of antimicrobial chemotherapy, 2018, 05-01, Volume: 73, Issue:5 Topics: Adult; Anti-Bacterial Agents; Critical Illness; Female; Healthy Volunteers; Humans; Lung; Male; Middle Aged; Piperacillin; Serum; Young Adult	2018
Pharmacokinetics of piperacillin in critically ill patients with acute kidney injury receiving sustained low-efficiency diafiltration. The Journal of antimicrobial chemotherapy, 2018, 06-01, Volume: 73, Issue:6 Topics: Acute Kidney Injury; Aged; Anti-Bacterial Agents; Critical Illness; Female; Filtration; Humans; Intensive Care Units; Male; Microbial Sensitivity Tests; Middle Aged; Piperacillin; Prospective Studies; Renal Dialysis; Renal Replacement Therapy; Tazobactam	2018
Piperacillin Population Pharmacokinetics in Critically Ill Adults During Sustained Low-Efficiency Dialysis. The Annals of pharmacotherapy, 2018, Volume: 52, Issue:10 Topics: Adult; Aged; Anti-Bacterial Agents; Critical Illness; Female; Humans; Intensive Care Units; Male; Microbial Sensitivity Tests; Middle Aged; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Renal Dialysis; Renal Replacement Therapy; Tazobactam	2018
Piperacillin Population Pharmacokinetics and Dosing Regimen Optimization in Critically Ill Children with Normal and Augmented Renal Clearance. Clinical pharmacokinetics, 2019, Volume: 58, Issue:2 Topics: Adolescent; Anti-Bacterial Agents; Bacteria; Child; Child, Preschool; Critical Illness; Female; Humans; Infant; Kidney; Male; Microbial Sensitivity Tests; Models, Biological; Piperacillin; Tazobactam	2019
Pharmacodynamic Target Attainment for Cefepime, Meropenem, and Piperacillin-Tazobactam Using a Pharmacokinetic/Pharmacodynamic-Based Dosing Calculator in Critically Ill Patients. Antimicrobial agents and chemotherapy, 2018, Volume: 62, Issue:9 Topics: Anti-Bacterial Agents; Cefepime; Critical Illness; Female; Humans; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Tazobactam	2018
The kinetic glomerular filtration rate is not interchangeable with measured creatinine clearance for prediction of piperacillin underexposure in critically ill patients with augmented renal clearance. Critical care (London, England), 2018, 07-23, Volume: 22, Issue:1 Topics: Creatinine; Critical Illness; Dose-Response Relationship, Drug; Glomerular Filtration Rate; Humans; Kidney; Kidney Function Tests; Metabolic Clearance Rate; Piperacillin	2018
Therapeutic drug monitoring of β-lactam antibiotics in the critically ill: direct measurement of unbound drug concentrations to achieve appropriate drug exposures. The Journal of antimicrobial chemotherapy, 2018, 11-01, Volume: 73, Issue:11 Topics: Adult; Aged; Anti-Bacterial Agents; beta-Lactams; Ceftriaxone; Critical Illness; Drug Monitoring; Female; Humans; Logistic Models; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Piperacillin; Prospective Studies; Treatment Outcome	2018
Measuring Unbound Versus Total Piperacillin Concentrations in Plasma of Critically Ill Patients: Methodological Issues and Relevance. Therapeutic drug monitoring, 2019, Volume: 41, Issue:3 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Piperacillin; Plasma; Protein Binding; Ultrafiltration	2019
Incidence of Acute Kidney Injury in Critically Ill Patients Receiving Vancomycin with Concomitant Piperacillin-Tazobactam, Cefepime, or Meropenem. Antimicrobial agents and chemotherapy, 2019, Volume: 63, Issue:5 Topics: Acute Kidney Injury; Aged; Cefepime; Critical Illness; Female; Humans; Incidence; Male; Meropenem; Middle Aged; Multivariate Analysis; Piperacillin; Retrospective Studies; Tazobactam; Vancomycin	2019
Vancomycin/Piperacillin-tazobactam Nephrotoxicity in the Critically Ill. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020, 03-17, Volume: 70, Issue:7 Topics: Acute Kidney Injury; Anti-Bacterial Agents; Critical Illness; Humans; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies; Vancomycin	2020
Subtherapeutic piperacillin concentrations in neurocritical patients. Journal of critical care, 2019, Volume: 54 Topics: Adult; Aged; Anti-Bacterial Agents; Critical Care; Critical Illness; Female; Humans; Intensive Care Units; Kidney; Kidney Function Tests; Male; Middle Aged; Multivariate Analysis; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Pseudomonas aeruginosa; Retrospective Studies; Risk Factors	2019
Pharmacokinetics of meropenem and piperacillin in critically ill patients with indwelling surgical drains. International journal of antimicrobial agents, 2013, Volume: 42, Issue:1 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Chromatography, Liquid; Critical Illness; Drainage; Exudates and Transudates; Female; Humans; Male; Meropenem; Middle Aged; Piperacillin; Plasma; Prospective Studies; Thienamycins; Urine	2013
Meropenem and piperacillin/tazobactam prescribing in critically ill patients: does augmented renal clearance affect pharmacokinetic/pharmacodynamic target attainment when extended infusions are used? Critical care (London, England), 2013, May-03, Volume: 17, Issue:3 Topics: Adult; Aged; Anti-Bacterial Agents; Creatinine; Critical Illness; Drug Delivery Systems; Female; Humans; Infusions, Intravenous; Kidney; Male; Meropenem; Metabolic Clearance Rate; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Thienamycins	2013
Antibiotics for the critically ill: more than just selecting appropriate initial therapy. Critical care (London, England), 2013, May-23, Volume: 17, Issue:3 Topics: Critical Illness; Drug Delivery Systems; Female; Humans; Kidney; Male; Meropenem; Metabolic Clearance Rate; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Thienamycins	2013
Pharmacokinetic analysis of piperacillin administered with tazobactam in critically ill, morbidly obese surgical patients. Pharmacotherapy, 2014, Volume: 34, Issue:1 Topics: Aged; Anti-Bacterial Agents; Critical Illness; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Obesity, Morbid; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies	2014
Population pharmacokinetics of piperacillin/tazobactam in critically ill young children. The Pediatric infectious disease journal, 2014, Volume: 33, Issue:2 Topics: Bacterial Infections; Child; Child, Preschool; Cohort Studies; Critical Illness; Female; Humans; Infant; Intensive Care Units, Pediatric; Male; Monte Carlo Method; Penicillanic Acid; Philadelphia; Piperacillin; Piperacillin, Tazobactam Drug Combination	2014
Alternative diagnosis to heparin-induced thrombocytopenia in two critically ill patients despite a positive PF4/heparin-antibody test. Upsala journal of medical sciences, 2013, Volume: 118, Issue:4 Topics: Aged; Critical Illness; Diagnosis, Differential; Enzyme-Linked Immunosorbent Assay; Femoral Neck Fractures; Heparin; Humans; Methotrexate; Pancytopenia; Penicillanic Acid; Piperacillin; Platelet Count; Platelet Factor 4; Purpura, Thrombocytopenic; Tazobactam; Thrombocytopenia; Transfusion Reaction	2013
Pharmacokinetics of piperacillin and tazobactam in plasma and subcutaneous interstitial fluid in critically ill patients receiving continuous venovenous haemodiafiltration. International journal of antimicrobial agents, 2014, Volume: 43, Issue:4 Topics: Acute Kidney Injury; Adolescent; Adult; Aged; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Critical Illness; Extracellular Fluid; Female; Half-Life; Hemofiltration; Humans; Male; Middle Aged; Penicillanic Acid; Piperacillin; Prospective Studies; Sepsis; Tazobactam	2014
The impact of variation in renal replacement therapy settings on piperacillin, meropenem, and vancomycin drug clearance in the critically ill: an analysis of published literature and dosing regimens. Critical care medicine, 2014, Volume: 42, Issue:7* Topics: Acute Kidney Injury; Anti-Bacterial Agents; Critical Illness; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Intensive Care Units; Male; Meropenem; Metabolic Clearance Rate; Middle Aged; Piperacillin; Renal Replacement Therapy; Thienamycins; Vancomycin	2014
Does consistent piperacillin dosing result in consistent therapeutic concentrations in critically ill patients? A longitudinal study over an entire antibiotic course. International journal of antimicrobial agents, 2014, Volume: 43, Issue:5 Topics: Adolescent; Adult; Aged; Anti-Bacterial Agents; Chromatography, Liquid; Cohort Studies; Critical Care; Critical Illness; Female; Humans; Longitudinal Studies; Male; Microbial Sensitivity Tests; Middle Aged; Piperacillin; Plasma; Prospective Studies; Pseudomonas aeruginosa; Tandem Mass Spectrometry; Young Adult	2014
Modified Augmented Renal Clearance score predicts rapid piperacillin and tazobactam clearance in critically ill surgery and trauma patients. The journal of trauma and acute care surgery, 2014, Volume: 77, Issue:3 Suppl 2 Topics: Adult; Aged, 80 and over; Anti-Bacterial Agents; Creatinine; Critical Illness; Cross-Sectional Studies; Female; Humans; Kidney Diseases; Male; Metabolic Clearance Rate; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Tazobactam; Wounds and Injuries; Young Adult	2014
Individualization of piperacillin dosing for critically ill patients: dosing software to optimize antimicrobial therapy. Antimicrobial agents and chemotherapy, 2014, Volume: 58, Issue:7 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Bayes Theorem; Creatinine; Critical Illness; Drug Dosage Calculations; Drug Therapy, Computer-Assisted; Female; Humans; Male; Metabolic Clearance Rate; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Precision Medicine; Pseudomonas aeruginosa; Young Adult	2014
Are standard doses of piperacillin sufficient for critically ill patients with augmented creatinine clearance? Critical care (London, England), 2015, Jan-30, Volume: 19 Topics: Adult; Aged; Anti-Bacterial Agents; Creatinine; Critical Illness; Female; Humans; Kidney Function Tests; Male; Metabolic Clearance Rate; Piperacillin; Renal Replacement Therapy	2015
Postoperative pneumonia following cardiac surgery in non-ventilated patients versus mechanically ventilated patients: is there any difference? Critical care (London, England), 2015, Mar-11, Volume: 19 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Cardiac Surgical Procedures; Critical Illness; Female; Gram-Negative Bacteria; Hospital Mortality; Humans; Incidence; Intensive Care Units; Male; Middle Aged; Piperacillin; Pneumonia; Pneumonia, Ventilator-Associated; Postoperative Complications; Respiration, Artificial; Retrospective Studies; Severity of Illness Index	2015
Pharmacokinetics of an extended 4-hour infusion of piperacillin-tazobactam in critically ill patients undergoing continuous renal replacement therapy. Pharmacotherapy, 2015, Volume: 35, Issue:6 Topics: Aged; Anti-Bacterial Agents; Critical Illness; Female; Hemodiafiltration; Humans; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Pseudomonas aeruginosa; Pseudomonas Infections; Tertiary Care Centers	2015
Is prolonged infusion of piperacillin/tazobactam and meropenem in critically ill patients associated with improved pharmacokinetic/pharmacodynamic and patient outcomes? An observation from the Defining Antibiotic Levels in Intensive care unit patients (DA The Journal of antimicrobial chemotherapy, 2016, Volume: 71, Issue:1 Topics: Aged; Anti-Bacterial Agents; Blood Chemical Analysis; Critical Illness; Female; Humans; Infusions, Intravenous; Intensive Care Units; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Thienamycins; Treatment Outcome	2016
Top Guns: The "Maverick" and "Goose" of Empiric Therapy. Surgical infections, 2016, Volume: 17, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Animals; Anti-Bacterial Agents; Bacterial Infections; Critical Illness; Drug-Related Side Effects and Adverse Reactions; Female; Humans; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Renal Insufficiency; Retrospective Studies; Risk Assessment; Vancomycin	2016
Population Pharmacokinetics and Pharmacodynamics of Extended-Infusion Piperacillin and Tazobactam in Critically Ill Children. Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:1 Topics: Age Factors; Anti-Bacterial Agents; Area Under Curve; Child; Child, Preschool; Computer Simulation; Critical Illness; Drug Administration Schedule; Enterobacteriaceae; Enterobacteriaceae Infections; Female; Glomerular Filtration Rate; Half-Life; Humans; Infant; Intensive Care Units; Male; Microbial Sensitivity Tests; Monte Carlo Method; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Sex Factors	2016
A pilot study on pharmacokinetic/pharmacodynamic target attainment in critically ill patients receiving piperacillin/tazobactam. Anaesthesiology intensive therapy, 2016, Volume: 48, Issue:1 Topics: Adult; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Critical Illness; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Pilot Projects; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies	2016
Serum β-lactam concentrations in critically ill patients with cirrhosis: a matched case-control study. Liver international : official journal of the International Association for the Study of the Liver, 2016, Volume: 36, Issue:7 Topics: Aged; Anti-Bacterial Agents; Belgium; Case-Control Studies; Chromatography, High Pressure Liquid; Critical Illness; Databases, Factual; Drug Monitoring; Female; Humans; Liver Cirrhosis; Logistic Models; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Multivariate Analysis; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Sepsis; Thienamycins	2016
What is the effect of obesity on piperacillin and meropenem trough concentrations in critically ill patients? The Journal of antimicrobial chemotherapy, 2016, Volume: 71, Issue:3 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Australia; Critical Illness; Female; Germany; Humans; Male; Meropenem; Microbial Sensitivity Tests; Middle Aged; Obesity; Piperacillin; Plasma; Pseudomonas aeruginosa; Retrospective Studies; Spain; Thienamycins; Young Adult	2016
Piperacillin population pharmacokinetics in critically ill patients with multiple organ dysfunction syndrome receiving continuous venovenous haemodiafiltration: effect of type of dialysis membrane on dosing requirements. The Journal of antimicrobial chemotherapy, 2016, Volume: 71, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Body Weight; Chromatography, Liquid; Critical Illness; Female; Hemodiafiltration; Humans; Infusions, Intravenous; Male; Mass Spectrometry; Microbial Sensitivity Tests; Middle Aged; Multiple Organ Failure; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Plasma; Prospective Studies; Tertiary Care Centers; Young Adult	2016
Comparative Incidence of Acute Kidney Injury in Critically Ill Patients Receiving Vancomycin with Concomitant Piperacillin-Tazobactam or Cefepime: A Retrospective Cohort Study. Pharmacotherapy, 2016, Volume: 36, Issue:5 Topics: Acute Kidney Injury; Anti-Bacterial Agents; Arkansas; Cefepime; Cephalosporins; Critical Illness; Drug Therapy, Combination; Female; Humans; Incidence; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies; Vancomycin	2016
Piperacillin concentration in relation to therapeutic range in critically ill patients--a prospective observational study. Critical care (London, England), 2016, Apr-04, Volume: 20 Topics: Aged; Anti-Bacterial Agents; Critical Care; Critical Illness; Dose-Response Relationship, Drug; Female; Germany; Humans; Kidney Function Tests; Male; Metabolic Clearance Rate; Middle Aged; Piperacillin; Prospective Studies; Renal Replacement Therapy	2016
Is high-dose β-lactam therapy associated with excessive drug toxicity in critically ill patients? Minerva anestesiologica, 2016, Volume: 82, Issue:9 Topics: Adult; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Chemical and Drug Induced Liver Injury; Cholestasis; Critical Illness; Drug Monitoring; Female; Humans; Male; Meropenem; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Renal Replacement Therapy; Retrospective Studies; Seizures; Thienamycins; Thrombocytopenia	2016
Pharmacokinetics and Pharmacodynamics of Extended Infusion Versus Short Infusion Piperacillin-Tazobactam in Critically Ill Patients Undergoing CRRT. Clinical journal of the American Society of Nephrology : CJASN, 2016, 08-08, Volume: 11, Issue:8 Topics: Acute Kidney Injury; Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Critical Illness; Dialysis Solutions; Female; Hemodiafiltration; Humans; Infusions, Intravenous; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Time Factors	2016
Effect of different renal function on antibacterial effects of piperacillin against Pseudomonas aeruginosa evaluated via the hollow-fibre infection model and mechanism-based modelling. The Journal of antimicrobial chemotherapy, 2016, Volume: 71, Issue:9 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Kidney; Microbial Sensitivity Tests; Models, Theoretical; Piperacillin; Pseudomonas aeruginosa; Pseudomonas Infections	2016
We need to optimize piperacillin-tazobactam dosing in critically ill patients-but how? Critical care (London, England), 2016, 06-06, Volume: 20, Issue:1 Topics: Anti-Bacterial Agents; Critical Illness; Humans; Penicillanic Acid; Piperacillin	2016
Variability of piperacillin concentrations in relation to tazobactam concentrations in critically ill patients. International journal of antimicrobial agents, 2016, Volume: 48, Issue:4 Topics: Aged; Anti-Bacterial Agents; beta-Lactamase Inhibitors; Critical Illness; Drug Monitoring; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Serum	2016
Clinical Outcomes of Extended Versus Intermittent Infusion of Piperacillin/Tazobactam in Critically Ill Patients: A Prospective Clinical Trial. Pharmacotherapy, 2017, Volume: 37, Issue:1 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Critical Illness; Female; Humans; Intensive Care Units; Length of Stay; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies	2017
Repeated Piperacillin-Tazobactam Plasma Concentration Measurements in Severely Obese Versus Nonobese Critically Ill Septic Patients and the Risk of Under- and Overdosing. Critical care medicine, 2017, Volume: 45, Issue:5 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Body Mass Index; Critical Illness; Dose-Response Relationship, Drug; Female; Humans; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Middle Aged; Monte Carlo Method; Obesity; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Prospective Studies; Shock, Septic	2017
Influence of antipseudomonal agents on Pseudomonas aeruginosa colonization and acquisition of resistance in critically ill medical patients. Intensive care medicine, 2009, Volume: 35, Issue:3 Topics: Adult; Cephalosporins; Critical Illness; Cross Infection; Drug Combinations; Drug Resistance, Microbial; Drug Therapy, Combination; Enzyme Inhibitors; Female; Genes, Viral; Genotype; Humans; Intensive Care Units; Male; Pharynx; Piperacillin; Prospective Studies; Pseudomonas aeruginosa; Pseudomonas Infections; Quinolones; Rectum; Respiratory Mucosa	2009
First-dose and steady-state population pharmacokinetics and pharmacodynamics of piperacillin by continuous or intermittent dosing in critically ill patients with sepsis. International journal of antimicrobial agents, 2010, Volume: 35, Issue:2 Topics: Adult; Aged; Anti-Bacterial Agents; Bacterial Infections; Critical Illness; Female; Humans; Male; Microbial Sensitivity Tests; Middle Aged; Monte Carlo Method; Piperacillin; Plasma; Sepsis; Young Adult	2010
Daily serum piperacillin monitoring is advisable in critically ill patients. International journal of antimicrobial agents, 2010, Volume: 35, Issue:5 Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Bacterial Infections; Critical Illness; Drug Monitoring; Female; France; Hospitals, Teaching; Humans; Infusions, Intravenous; Injections, Intravenous; Male; Middle Aged; Penicillanic Acid; Piperacillin; Prospective Studies; Serum; Tazobactam; Time Factors	2010
Variability of antibiotic concentrations in critically ill patients receiving continuous renal replacement therapy: a multicentre pharmacokinetic study. Critical care medicine, 2012, Volume: 40, Issue:5 Topics: Acute Kidney Injury; Aged; Anti-Bacterial Agents; Ciprofloxacin; Critical Illness; Female; Hemofiltration; Humans; Male; Meropenem; Middle Aged; Penicillanic Acid; Piperacillin; Tazobactam; Thienamycins; Vancomycin	2012
Continuous infusion of piperacillin/tazobactam in septic critically ill patients--a multicenter propensity matched analysis. PloS one, 2012, Volume: 7, Issue:11 Topics: Adult; Aged; Anti-Bacterial Agents; Bacteria; Critical Illness; Female; Humans; Infections; Intensive Care Units; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Portugal	2012
Outcomes of extended-infusion piperacillin-tazobactam: a retrospective analysis of critically ill patients. Clinical therapeutics, 2012, Volume: 34, Issue:12 Topics: Aged; Anti-Bacterial Agents; Critical Illness; Drug Administration Schedule; Female; Gram-Negative Bacterial Infections; Humans; Infusions, Intravenous; Male; Middle Aged; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Retrospective Studies	2012
Pharmacodynamics of piperacillin in severely ill patients evaluated by using a PK/PD model. International journal of antimicrobial agents, 2003, Volume: 22, Issue:6 Topics: Colony Count, Microbial; Critical Illness; Humans; In Vitro Techniques; Microbial Sensitivity Tests; Models, Biological; Piperacillin; Pseudomonas aeruginosa; Pseudomonas Infections; Soft Tissue Infections; Staphylococcal Infections; Staphylococcus aureus	2003
Piperacillin-tazobactam for Pseudomonas aeruginosa infection: clinical implications of an extended-infusion dosing strategy. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2007, Feb-01, Volume: 44, Issue:3 Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; APACHE; beta-Lactams; Cohort Studies; Critical Illness; Cross Infection; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Infusions, Intravenous; Male; Microbial Sensitivity Tests; Middle Aged; Models, Biological; Monte Carlo Method; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pseudomonas Infections; Retrospective Studies	2007
A novel way to investigate the effects of plasma exchange on antibiotic levels: use of microdialysis. International journal of antimicrobial agents, 2008, Volume: 31, Issue:3 Topics: Adolescent; Anti-Bacterial Agents; Critical Illness; Guillain-Barre Syndrome; Humans; Infusions, Intravenous; Male; Microdialysis; Piperacillin; Plasma Exchange; Pneumonia, Ventilator-Associated; Serum; Subcutaneous Tissue	2008
Removal of piperacillin in critically ill patients undergoing continuous venovenous hemofiltration. Critical care medicine, 1998, Volume: 26, Issue:1 Topics: Aged; Aged, 80 and over; Chromatography, High Pressure Liquid; Critical Illness; Dialysis Solutions; Half-Life; Hemofiltration; Humans; Infusions, Intravenous; Liver Failure; Middle Aged; Multiple Organ Failure; Penicillins; Piperacillin; Prospective Studies; Renal Insufficiency; Shock, Cardiogenic; Shock, Septic	1998