piperacillin--tazobactam-drug-combination and Periodontal-Pocket

Topics: Anti-Bacterial Agents; Doxycycline; Humans; Periodontal Pocket; Periodontitis; Piperacillin, Tazobactam Drug Combination; Porphyromonas gingivalis

We assessed if adjunct administration of piperacillin/tazobactam added clinical and microbiological treatment benefits.. Thirty-six subjects (mean age 52.1 years (SD ± 10.3)) (NS by group) with chronic periodontitis were randomly enrolled receiving subgingival debridement and the local administration of piperacillin/tazobactam (test group) or debridement alone (control group). Bleeding on probing (BOP), probing pocket depth (PPD), and microbiological counts of 74 species were studied by checkerboard DNA-DNA hybridization up to month 6 after treatment.. Mean PPD changes between baseline and month 6 in the test and control groups were 1.5 and 1.8 mm, respectively (NS between groups). BOP in both groups decreased from about 80 to 40 %. At 4 and 12 weeks, lower counts of the following bacteria were found in the test group (site level): Fusobacterium species, Parvimonas micra, Pseudomonas aeruginosa, Staphylococcus aureus, Tannerella forsythia, Treponema denticola, and a composite load of nine pathogens (p < 0.001). At week 26, subjects receiving local antibiotics had a lower prevalence at tested sites for Fusobacterium nucleatum sp. polymorphum, Fusobacterium periodonticum, P. micra, and T. denticola.. At 26 weeks, treatment with or without piperacillin/tazobactam resulted in similar BOP and PPD improvements. At week 26 and at the subject level, the prevalence of 4/74 pathogens was found at lower counts in the group receiving local antibiotics.. Administration of piperacillin/tazobactam reduces the prevalence of Fusobacterium, P. micra, and T. denticola to a greater extent than debridement alone but with no short-term differences in PPD or BOP.

Topics: Anti-Bacterial Agents; Chronic Periodontitis; Combined Modality Therapy; Debridement; Female; Gingival Hemorrhage; Humans; Male; Middle Aged; Penicillanic Acid; Periodontal Pocket; Piperacillin; Piperacillin, Tazobactam Drug Combination; Treatment Outcome