piperacillin--tazobactam-drug-combination and Meningitis--Bacterial

Topics: Adult; Animals; Anti-Bacterial Agents; C-Reactive Protein; Ceftriaxone; Ciprofloxacin; Female; Fusobacterium Infections; Humans; Hypoxia; Meningitis, Bacterial; Penicillanic Acid; Pets; Piperacillin; Piperacillin, Tazobactam Drug Combination; Pneumonia, Bacterial; Rats; Respiratory Distress Syndrome; Streptobacillus; Thrombocytopenia

Elizabethkingia meningoseptica is a multi-drug resistant organism that can cause meningitis in premature neonates. We report a case of Elizabethkingia meningoseptica meningitis that was detected early in an extremely premature low birth weight infant. He was successfully treated with a combination of ciprofloxacin and piperacillin-tazobactam. The spread of infection was controlled with no other reported cases.

Topics: Anti-Bacterial Agents; Ciprofloxacin; Flavobacteriaceae; Flavobacteriaceae Infections; Humans; Infant, Newborn; Male; Meningitis, Bacterial; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Saudi Arabia; Treatment Outcome

The transferability of tazobactam/piperacillin (TAZ/PIPC) to cerebrospinal fluid (CSF) was studied employing rabbits with experimental meningitis caused by Staphylococcus aureus. 125 or 250 mg/kg of TAZ/PIPC was intravenously administered to rabbits with experimental meningitis then concentrations of TAZ and PIPC in CSF and serum were measured. In the group to which 125 mg/kg of TAZ/PIPC was administered, mean concentration of TAZ in CSF was 7.3 and 2.4 micrograms/ml at 30 and 60 min after administration, respectively, and concerning PIPC, it was 10.1 and 3.5 micrograms/ml, respectively. CSF/serum ratio of TAZ was 29.4% and 31.4%, respectively, and that of PIPC was 24.3 and 35.6%, respectively. In the group to which 250 mg/kg of TAZ/PIPC was administered, mean concentration of TAZ in CSF was 16.5 and 12.6% micrograms/ml, respectively, and concerning PIPC, it was 25.6 and 18.2 micrograms/ml, respectively. CSF/serum ratio of TAZ was 22.1 and 56.1%, respectively, and that of PIPC was 12.2 and 51.9%, respectively. Addition of TAZ did not make significant change of transferability of PIPC to CSF. Considering the antibacterial effect of TAZ/PIPC against main causative organism of meningitis, this agent was thought to be effective for the treatment of purulent meningitis.

Topics: Animals; beta-Lactamase Inhibitors; Drug Therapy, Combination; Enzyme Inhibitors; Meningitis, Bacterial; Penicillanic Acid; Penicillins; Piperacillin; Piperacillin, Tazobactam Drug Combination; Rabbits; Staphylococcal Infections; Tazobactam; Time Factors