piperacillin--tazobactam-drug-combination and Diabetes-Mellitus

Bacteroides caccae is a ubiquitous, anaerobic bacteria, but it is not a common cause of pathologic bloodstream infection. Diabetic patients are at increased risk of developing anaerobic bacteria infection. Here, we report a repeated fever case caused by Bacteroides caccae in a diabetic patient. The aim of this study was to describe the clinical characteristics and manifestations of Bacteroides caccae.. The pathogenic bacteria isolated from patient blood was identified as Bacteroides caccae. Identification of the Bacteroides caccae was done by 16s rDNA sequencing and matrix-assisted laser desorption/ionization-time of light spectrometry. The infection was cured by one-week combined therapy of intravenous Piperacillin tazobactam and oral Ornidazole tablet.. After treatment had been completed, no episodes of fever occurred during the follow-up to date.. Bacteroides caccae is regarded as an intestinal, opportunistic pathogenic bacteria. It can invade the mucosa of the intestine and cause various abdominal suppurative infections. Sequencing and matrix-assisted laser desorption/ionization-time of flight spectrometry could have a role for Bacteroides caccae diagnosis. The curative effect of using first generation cephalosporines therapy was unsatisfactory. Using intravenous Piperacillin tazobactam and ornidazole tablet might obtain certain curative effect. Early diagnosis and appropriate anti-infection therapy were necessary to improve the outcome of patients with Bacteroides caccae bloodstream infection.

Topics: Bacteroides; Bacteroides Infections; Diabetes Complications; Diabetes Mellitus; Drug Therapy, Combination; Female; Fever; Humans; Middle Aged; Ornidazole; Piperacillin, Tazobactam Drug Combination

Topics: Anti-Bacterial Agents; Comorbidity; Diabetes Mellitus; Diabetic Ketoacidosis; Drug Therapy, Combination; Emphysema; Humans; Hypertension; Kidney Transplantation; Male; Middle Aged; Norepinephrine; Penicillanic Acid; Piperacillin; Piperacillin, Tazobactam Drug Combination; Postoperative Complications; Pyelonephritis; Tomography, X-Ray Computed; Transplantation, Homologous; Vancomycin