piperacillin--tazobactam-drug-combination and Acquired-Immunodeficiency-Syndrome

Piperacillin/tazobactam is a commonly prescribed antimicrobial agent. Tenofovir alafenamide (TAF) is increasingly being used in antiretroviral therapy (ART) of HIV. Herein we report a case of a 57-year-old male with AIDS receiving TAF-containing ART in whom severe refractory hypokalaemia developed after coadministration of piperacillin/tazobactam for suspected hospital-acquired infection. Upon withdrawal of piperacillin/tazobactam, serum potassium concentrations returned to normal within 2 days. Hypokalaemia is a rare adverse effect of piperacillin/tazobactam and may be aggravated with the underlying use of TAF. We also reviewed past reported cases of hypokalaemia after piperacillin/tazobactam administration. We want to highlight that a more cautious approach should be considered when combining piperacillin/tazobactam and TAF in clinical practice.

Topics: Acquired Immunodeficiency Syndrome; Alanine; Antiviral Agents; Humans; Hypokalemia; Male; Middle Aged; Piperacillin, Tazobactam Drug Combination; Tenofovir

Topics: Acquired Immunodeficiency Syndrome; AIDS-Related Opportunistic Infections; Anti-Bacterial Agents; Bordetella bronchiseptica; Bordetella Infections; Cough; Humans; Lung; Lymphoma, Large B-Cell, Diffuse; Male; Piperacillin, Tazobactam Drug Combination; Treatment Outcome; Vancomycin; Young Adult