pipecolic acid has been researched along with Seizures in 14 studies
pipecolic acid: RN given refers to cpd without isomeric designation
pipecolic acid : A piperidinemonocarboxylic acid in which the carboxy group is located at position C-2.
pipecolate : A piperidinecarboxylate that is the conjugate base of pipecolic acid.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyridoxine dependency is an uncommon but important cause of intractable seizures presenting in infancy and early childhood." | 8.83 | Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment. ( Gospe, SM, 2006) |
| "To analyze the clinical and genetic characteristics of patients with pyridoxine dependent epilepsy (PDE), and build a method to detect and analyze the concentration of urinary pipecolic acid in PDE patients receiving pyridoxine treatment." | 7.83 | [Clinical and genetic characteristics and detection of urinary pipecolic acid in pyridoxine dependent epilepsy]. ( Jiang, YW; Li, H; Liu, XY; Qian, P; Wu, Y; Xue, J; Yang, ZX, 2016) |
| "Folinic acid-responsive seizures and pyridoxine-dependent epilepsy are two treatable causes of neonatal epileptic encephalopathy." | 7.75 | Folinic acid-responsive seizures are identical to pyridoxine-dependent epilepsy. ( Gallagher, RC; Hyland, K; Jakobs, C; Mercimek-Mahmutoglu, S; Plecko, B; Rosenberg, EH; Salomons, GS; Scharer, G; Stockler-Ipsiroglu, S; Struys, EA; Van Hove, JL; Waters, PJ, 2009) |
| "L-lysine, an essential amino acid for man and animals, and its metabolite pipecolic acid (PA) have been studied for their effects on pentylenetetrazol (PTZ)-induced seizures in mice." | 7.67 | Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures. ( Chang, YF; Chen, JS; Hargest, V, 1988) |
| "Lysine and its metabolic intermediates were studied for their effect on pentylenetetrazol (PTZ)-induced seizures in mice." | 7.67 | Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures. ( Chang, YF; Myslinski, NR, 1985) |
| "Pyridoxine-dependent seizures (PDS) is an autosomal recessive disorder characterized by seizures presenting in neonates or infants up to 3 years of age which respond to pharmacological doses of pyridoxine." | 5.35 | Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures. ( Gospe, SM; Hahn, SH; Sadilkova, K, 2009) |
| "Pyridoxine dependency is an uncommon but important cause of intractable seizures presenting in infancy and early childhood." | 4.83 | Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment. ( Gospe, SM, 2006) |
| "To analyze the clinical and genetic characteristics of patients with pyridoxine dependent epilepsy (PDE), and build a method to detect and analyze the concentration of urinary pipecolic acid in PDE patients receiving pyridoxine treatment." | 3.83 | [Clinical and genetic characteristics and detection of urinary pipecolic acid in pyridoxine dependent epilepsy]. ( Jiang, YW; Li, H; Liu, XY; Qian, P; Wu, Y; Xue, J; Yang, ZX, 2016) |
| "Pyridoxine-dependent seizure (PDS) is a rare disorder characterized by seizures that are resistant to common anticonvulsants, and that are ultimately controlled by daily pharmacologic doses of pyridoxine (vitamin B6)." | 3.75 | Prevalence of ALDH7A1 mutations in 18 North American pyridoxine-dependent seizure (PDS) patients. ( Bennett, CL; Chen, Y; Glass, IA; Gospe, SM; Hahn, S, 2009) |
| "Folinic acid-responsive seizures and pyridoxine-dependent epilepsy are two treatable causes of neonatal epileptic encephalopathy." | 3.75 | Folinic acid-responsive seizures are identical to pyridoxine-dependent epilepsy. ( Gallagher, RC; Hyland, K; Jakobs, C; Mercimek-Mahmutoglu, S; Plecko, B; Rosenberg, EH; Salomons, GS; Scharer, G; Stockler-Ipsiroglu, S; Struys, EA; Van Hove, JL; Waters, PJ, 2009) |
| "The relative ability of derivatives of 2-piperidinecarboxylic acid (2-PC; pipecolic acid) and 3-piperidinecarboxylic acid (3-PC; nipecotic acid) to block maximal electroshock (MES)-induced seizures, elevate the threshold for electroshock-induced seizures and be neurotoxic in mice was investigated." | 3.69 | Anticonvulsant activity of novel derivatives of 2- and 3-piperidinecarboxylic acid in mice and rats. ( Andersen, PH; Burns, CM; Chang, H; Crider, AM; el-Assadi, AA; Hinko, CN; Ho, B; Kliem, MA; Klitgaard, H; Seo, TH; Steinmiller, CL; Tietz, EI; Venkatarangan, P, 1996) |
| "L-lysine, an essential amino acid for man and animals, and its metabolite pipecolic acid (PA) have been studied for their effects on pentylenetetrazol (PTZ)-induced seizures in mice." | 3.67 | Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures. ( Chang, YF; Chen, JS; Hargest, V, 1988) |
| "Lysine and its metabolic intermediates were studied for their effect on pentylenetetrazol (PTZ)-induced seizures in mice." | 3.67 | Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures. ( Chang, YF; Myslinski, NR, 1985) |
| "Pyridoxine-dependent seizures (PDS) is an autosomal recessive disorder characterized by seizures presenting in neonates or infants up to 3 years of age which respond to pharmacological doses of pyridoxine." | 1.35 | Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures. ( Gospe, SM; Hahn, SH; Sadilkova, K, 2009) |
| "Animals developed severe limbic seizures between 1 and 6 h after L-AAA injection, characterized by generalized convulsions." | 1.30 | L-alpha-aminoadipate inhibits kynurenate synthesis in rat brain hippocampus and tissue culture. ( Cauley, RK; Chang, JD; Chang, YF; Rao, VV, 1997) |
| "The age related audiogenic seizure susceptibility of DBA/2 mice is not related to an abnormality of neuronal GABA uptake." | 1.27 | Synaptosomal [3H]GABA uptake and [3H]nipecotic acid binding in audiogenic seizure susceptible (DBA/2) and resistant (C57 B1/6) mice. ( Horton, RW; Prestwich, SA; Spyrou, NA, 1984) |
| "Pipecolic acid (PA) is an alicyclic amino acid and putative neurotransmitter which may modulate GABAergic transmission in the central nervous system." | 1.27 | Inhibition of intrathecally administered picrotoxin- and bicuculline-induced convulsions in mice by pipecolic acid or GABA. ( Beitz, AJ; Larson, AA, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (42.86) | 18.7374 |
| 1990's | 2 (14.29) | 18.2507 |
| 2000's | 4 (28.57) | 29.6817 |
| 2010's | 1 (7.14) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Spyrou, NA | 1 |
| Prestwich, SA | 1 |
| Horton, RW | 1 |
| Hinko, CN | 2 |
| Crider, AM | 2 |
| Kliem, MA | 1 |
| Steinmiller, CL | 1 |
| Seo, TH | 1 |
| Ho, B | 1 |
| Venkatarangan, P | 1 |
| el-Assadi, AA | 1 |
| Chang, H | 1 |
| Burns, CM | 1 |
| Tietz, EI | 1 |
| Andersen, PH | 1 |
| Klitgaard, H | 1 |
| Beitz, AJ | 1 |
| Larson, AA | 1 |
| Wood, JD | 1 |
| Mathis, D | 1 |
| Beese, K | 1 |
| Rüegg, C | 1 |
| Plecko, B | 2 |
| Hersberger, M | 1 |
| Xue, J | 1 |
| Yang, ZX | 1 |
| Li, H | 1 |
| Qian, P | 1 |
| Wu, Y | 1 |
| Jiang, YW | 1 |
| Liu, XY | 1 |
| Bennett, CL | 1 |
| Chen, Y | 1 |
| Hahn, S | 1 |
| Glass, IA | 1 |
| Gospe, SM | 3 |
| Gallagher, RC | 1 |
| Van Hove, JL | 1 |
| Scharer, G | 1 |
| Hyland, K | 1 |
| Waters, PJ | 1 |
| Mercimek-Mahmutoglu, S | 1 |
| Stockler-Ipsiroglu, S | 1 |
| Salomons, GS | 1 |
| Rosenberg, EH | 1 |
| Struys, EA | 1 |
| Jakobs, C | 1 |
| Sadilkova, K | 1 |
| Hahn, SH | 1 |
| Chang, YF | 3 |
| Cauley, RK | 1 |
| Chang, JD | 1 |
| Rao, VV | 1 |
| Hargest, V | 1 |
| Chen, JS | 1 |
| Myslinski, NR | 1 |
| Bernasconi, R | 1 |
| Jones, RS | 1 |
| Bittiger, H | 1 |
| Olpe, HR | 1 |
| Heid, J | 1 |
| Martin, P | 1 |
| Klein, M | 1 |
| Loo, P | 1 |
| Braunwalder, A | 1 |
| Schmutz, M | 1 |
1 review available for pipecolic acid and Seizures
| Article | Year |
|---|---|
Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment.
Topics: Biomarkers; Humans; Pipecolic Acids; Pyridoxine; Seizures; Vitamin B 6 Deficiency | 2006 |
13 other studies available for pipecolic acid and Seizures
| Article | Year |
|---|---|
Synaptosomal [3H]GABA uptake and [3H]nipecotic acid binding in audiogenic seizure susceptible (DBA/2) and resistant (C57 B1/6) mice.
Topics: Acoustic Stimulation; Age Factors; Animals; Cerebellum; Cerebral Cortex; gamma-Aminobutyric Acid; Mi | 1984 |
Anticonvulsant activity of novel derivatives of 2- and 3-piperidinecarboxylic acid in mice and rats.
Topics: 4-Aminopyridine; Amygdala; Animals; Anticonvulsants; Brain; Convulsants; Kindling, Neurologic; Male; | 1996 |
Inhibition of intrathecally administered picrotoxin- and bicuculline-induced convulsions in mice by pipecolic acid or GABA.
Topics: Animals; Bicuculline; gamma-Aminobutyric Acid; Injections, Spinal; Male; Mice; Nipecotic Acids; Picr | 1985 |
A comparison of prodrug esters of nipecotic acid.
Topics: Animals; Anticonvulsants; Bicuculline; Esters; GABA Antagonists; Male; Mice; Nipecotic Acids; Parasy | 1988 |
LC-MS/MS method for the differential diagnosis of treatable early onset inherited metabolic epilepsies.
Topics: Aldehyde Dehydrogenase; Biomarkers; Chromatography, Liquid; Diagnosis, Differential; Epilepsy; Human | 2020 |
[Clinical and genetic characteristics and detection of urinary pipecolic acid in pyridoxine dependent epilepsy].
Topics: Aldehyde Dehydrogenase; Asian People; Child; Child, Preschool; Delayed Diagnosis; DNA Mutational Ana | 2016 |
Prevalence of ALDH7A1 mutations in 18 North American pyridoxine-dependent seizure (PDS) patients.
Topics: Adolescent; Adult; Age of Onset; Aldehyde Dehydrogenase; Child; Child, Preschool; Cohort Studies; DN | 2009 |
Folinic acid-responsive seizures are identical to pyridoxine-dependent epilepsy.
Topics: Aldehyde Dehydrogenase; Biogenic Monoamines; DNA Mutational Analysis; Humans; Infant; Leucovorin; Li | 2009 |
Simultaneous determination of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate and pipecolic acid by LC-MS/MS for pyridoxine-dependent seizures and folinic acid-responsive seizures.
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Animals; Calibration; Cattle; Child; Child, Preschool; C | 2009 |
L-alpha-aminoadipate inhibits kynurenate synthesis in rat brain hippocampus and tissue culture.
Topics: 2-Aminoadipic Acid; Animals; Astrocytes; Cells, Cultured; Drug Evaluation, Preclinical; Hippocampus; | 1997 |
Modulation of benzodiazepine by lysine and pipecolic acid on pentylenetetrazol-induced seizures.
Topics: Animals; Biological Transport; Brain; Diazepam; Dose-Response Relationship, Drug; Flunitrazepam; Lys | 1988 |
Effects of L-lysine and its metabolites on pentylenetetrazol-induced seizures.
Topics: 2-Aminoadipic Acid; Animals; Anticonvulsants; gamma-Aminobutyric Acid; Lysine; Male; Mice; Pentylene | 1985 |
Dose pipecolic acid interact with the central GABA-ergic system?
Topics: Animals; Anticonvulsants; Brain; Brain Chemistry; gamma-Aminobutyric Acid; Male; Mice; Pipecolic Aci | 1986 |