pipecolic acid has been researched along with Metabolic Syndrome in 2 studies
pipecolic acid: RN given refers to cpd without isomeric designation
pipecolic acid : A piperidinemonocarboxylic acid in which the carboxy group is located at position C-2.
pipecolate : A piperidinecarboxylate that is the conjugate base of pipecolic acid.
Metabolic Syndrome: A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.
Excerpt | Relevance | Reference |
---|---|---|
"The betaines that were increased in mouse plasma after bran-enriched feeding were identified de novo via chemical synthesis and liquid chromatography-tandem mass spectrometry, and confirmed to be associated with an increased intake of whole-grain products in humans." | 2.87 | Diets rich in whole grains increase betainized compounds associated with glucose metabolism. ( Auriola, S; Giacco, R; Hanhineva, K; Jokkala, J; Kärkkäinen, O; Koistinen, V; Kolehmainen, M; Lankinen, MA; Lehtonen, M; Leppänen, J; Micard, V; Mykkänen, H; Poutanen, K; Riccardi, G; Rivellese, AAA; Rosa-Sibakov, N; Schwab, U; Uusitupa, M; Vitale, M, 2018) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Tuomainen, M | 1 |
Kärkkäinen, O | 2 |
Leppänen, J | 2 |
Auriola, S | 2 |
Lehtonen, M | 2 |
Savolainen, MJ | 1 |
Hermansen, K | 1 |
Risérus, U | 1 |
Åkesson, B | 1 |
Thorsdottir, I | 1 |
Kolehmainen, M | 2 |
Uusitupa, M | 2 |
Poutanen, K | 2 |
Schwab, U | 2 |
Hanhineva, K | 2 |
Lankinen, MA | 1 |
Vitale, M | 1 |
Jokkala, J | 1 |
Koistinen, V | 1 |
Giacco, R | 1 |
Rosa-Sibakov, N | 1 |
Micard, V | 1 |
Rivellese, AAA | 1 |
Mykkänen, H | 1 |
Riccardi, G | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
The Effect of Nordic Diet Rich in Whole Grain, Berries, Fruits, Vegetables and Fish on Features of Metabolic Syndrome - a Systems Biology Approach[NCT00992641] | 167 participants (Actual) | Interventional | 2009-08-31 | Completed | |||
Systems Biology Approach to Understand Dietary Modulation of Gene Expression and Metabolic Pathways in Subjects With Abnormal Glucose Metabolism (Sysdimet)[NCT00573781] | Phase 2 | 106 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
Effect of Whole Grain Rich Diet on Insulin Sensitivity in Individuals With Metabolic Syndrome[NCT00945854] | 60 participants (Actual) | Interventional | 2008-03-31 | Completed | |||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Peripheral insulin sensitivity was assessed by FSIGT. A glucose dose of 300 mg/kg body weight was given intravenously followed by a bolus of 0.03 U/kg of insulin injected after 20 min. Blood samples were frequently collected for 3 h for the measurement of plasma glucose and serum insulin concentrations, utilized to calculate the insulin sensitivity index Si (NCT00945854)
Timeframe: 12 weeks
Intervention | 104xmin-1/microU/ml (Mean) |
---|---|
Wholegrain Cereal Diet | 3.03 |
Refined Cereal Diet | 3.15 |
Blood samples during the standard meal test were drawn from an antecubital vein after a 12 h overnight fast and 0, 30, 60, 90, 120, 150 and 180 min postprandial for the measurement of plasma insulin response reported as average mean postprandial increment. (NCT00945854)
Timeframe: 12 weeks
Intervention | (microU/mlx3hrs) (Mean) |
---|---|
Wholegrain Cereal Diet | 50.01 |
Refined Cereal Diet | 64.4 |
Blood samples during the standard meal test were drawn from an antecubital vein after a 12 h overnight fast and 0, 30, 60, 90, 120, 150 and 180 min postprandial for the measurement of triglyceride response reported as average mean postprandial increment. (NCT00945854)
Timeframe: 12 weeks
Intervention | mg/dlx3hrs (Mean) |
---|---|
Wholegrain Cereal Diet | 22.7 |
Refined Cereal Diet | 47.6 |
2 trials available for pipecolic acid and Metabolic Syndrome
Article | Year |
---|---|
Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET).
Topics: Adult; Aged; Betaine; Biomarkers; Diet; Dietary Fiber; Female; Humans; Male; Mass Spectrometry; Meta | 2019 |
Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
Topics: Adult; Aged; Animals; Betaine; Blood Glucose; Chromatography, Liquid; Cohort Studies; Diet; Dietary | 2018 |
Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
Topics: Adult; Aged; Animals; Betaine; Blood Glucose; Chromatography, Liquid; Cohort Studies; Diet; Dietary | 2018 |
Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
Topics: Adult; Aged; Animals; Betaine; Blood Glucose; Chromatography, Liquid; Cohort Studies; Diet; Dietary | 2018 |
Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
Topics: Adult; Aged; Animals; Betaine; Blood Glucose; Chromatography, Liquid; Cohort Studies; Diet; Dietary | 2018 |