Page last updated: 2024-10-19

pipecolic acid and Metabolic Syndrome

pipecolic acid has been researched along with Metabolic Syndrome in 2 studies

pipecolic acid: RN given refers to cpd without isomeric designation
pipecolic acid : A piperidinemonocarboxylic acid in which the carboxy group is located at position C-2.
pipecolate : A piperidinecarboxylate that is the conjugate base of pipecolic acid.

Metabolic Syndrome: A cluster of symptoms that are risk factors for CARDIOVASCULAR DISEASES and TYPE 2 DIABETES MELLITUS. The major components of metabolic syndrome include ABDOMINAL OBESITY; atherogenic DYSLIPIDEMIA; HYPERTENSION; HYPERGLYCEMIA; INSULIN RESISTANCE; a proinflammatory state; and a prothrombotic (THROMBOSIS) state.

Research Excerpts

ExcerptRelevanceReference
"The betaines that were increased in mouse plasma after bran-enriched feeding were identified de novo via chemical synthesis and liquid chromatography-tandem mass spectrometry, and confirmed to be associated with an increased intake of whole-grain products in humans."2.87Diets rich in whole grains increase betainized compounds associated with glucose metabolism. ( Auriola, S; Giacco, R; Hanhineva, K; Jokkala, J; Kärkkäinen, O; Koistinen, V; Kolehmainen, M; Lankinen, MA; Lehtonen, M; Leppänen, J; Micard, V; Mykkänen, H; Poutanen, K; Riccardi, G; Rivellese, AAA; Rosa-Sibakov, N; Schwab, U; Uusitupa, M; Vitale, M, 2018)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Tuomainen, M1
Kärkkäinen, O2
Leppänen, J2
Auriola, S2
Lehtonen, M2
Savolainen, MJ1
Hermansen, K1
Risérus, U1
Åkesson, B1
Thorsdottir, I1
Kolehmainen, M2
Uusitupa, M2
Poutanen, K2
Schwab, U2
Hanhineva, K2
Lankinen, MA1
Vitale, M1
Jokkala, J1
Koistinen, V1
Giacco, R1
Rosa-Sibakov, N1
Micard, V1
Rivellese, AAA1
Mykkänen, H1
Riccardi, G1

Clinical Trials (3)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
The Effect of Nordic Diet Rich in Whole Grain, Berries, Fruits, Vegetables and Fish on Features of Metabolic Syndrome - a Systems Biology Approach[NCT00992641]167 participants (Actual)Interventional2009-08-31Completed
Systems Biology Approach to Understand Dietary Modulation of Gene Expression and Metabolic Pathways in Subjects With Abnormal Glucose Metabolism (Sysdimet)[NCT00573781]Phase 2106 participants (Actual)Interventional2007-09-30Completed
Effect of Whole Grain Rich Diet on Insulin Sensitivity in Individuals With Metabolic Syndrome[NCT00945854]60 participants (Actual)Interventional2008-03-31Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Insulin Sensitivity (Si)

Peripheral insulin sensitivity was assessed by FSIGT. A glucose dose of 300 mg/kg body weight was given intravenously followed by a bolus of 0.03 U/kg of insulin injected after 20 min. Blood samples were frequently collected for 3 h for the measurement of plasma glucose and serum insulin concentrations, utilized to calculate the insulin sensitivity index Si (NCT00945854)
Timeframe: 12 weeks

Intervention104xmin-1/microU/ml (Mean)
Wholegrain Cereal Diet3.03
Refined Cereal Diet3.15

Postprandial Insulin Changes

Blood samples during the standard meal test were drawn from an antecubital vein after a 12 h overnight fast and 0, 30, 60, 90, 120, 150 and 180 min postprandial for the measurement of plasma insulin response reported as average mean postprandial increment. (NCT00945854)
Timeframe: 12 weeks

Intervention(microU/mlx3hrs) (Mean)
Wholegrain Cereal Diet50.01
Refined Cereal Diet64.4

Postprandial Plasma Lipid Changes

Blood samples during the standard meal test were drawn from an antecubital vein after a 12 h overnight fast and 0, 30, 60, 90, 120, 150 and 180 min postprandial for the measurement of triglyceride response reported as average mean postprandial increment. (NCT00945854)
Timeframe: 12 weeks

Interventionmg/dlx3hrs (Mean)
Wholegrain Cereal Diet22.7
Refined Cereal Diet47.6

Trials

2 trials available for pipecolic acid and Metabolic Syndrome

ArticleYear
Quantitative assessment of betainized compounds and associations with dietary and metabolic biomarkers in the randomized study of the healthy Nordic diet (SYSDIET).
    The American journal of clinical nutrition, 2019, 11-01, Volume: 110, Issue:5

    Topics: Adult; Aged; Betaine; Biomarkers; Diet; Dietary Fiber; Female; Humans; Male; Mass Spectrometry; Meta

2019
Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
    The American journal of clinical nutrition, 2018, 11-01, Volume: 108, Issue:5

    Topics: Adult; Aged; Animals; Betaine; Blood Glucose; Chromatography, Liquid; Cohort Studies; Diet; Dietary

2018
Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
    The American journal of clinical nutrition, 2018, 11-01, Volume: 108, Issue:5

    Topics: Adult; Aged; Animals; Betaine; Blood Glucose; Chromatography, Liquid; Cohort Studies; Diet; Dietary

2018
Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
    The American journal of clinical nutrition, 2018, 11-01, Volume: 108, Issue:5

    Topics: Adult; Aged; Animals; Betaine; Blood Glucose; Chromatography, Liquid; Cohort Studies; Diet; Dietary

2018
Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
    The American journal of clinical nutrition, 2018, 11-01, Volume: 108, Issue:5

    Topics: Adult; Aged; Animals; Betaine; Blood Glucose; Chromatography, Liquid; Cohort Studies; Diet; Dietary

2018