pipecolic acid has been researched along with Epilepsy in 18 studies
pipecolic acid: RN given refers to cpd without isomeric designation
pipecolic acid : A piperidinemonocarboxylic acid in which the carboxy group is located at position C-2.
pipecolate : A piperidinecarboxylate that is the conjugate base of pipecolic acid.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyridoxine-dependent epilepsy (PDE) is a recessive genetic disease characterized by epileptic encephalopathy with therapeutic response to pharmacological doses of pyridoxine and resistance to anti-epileptic treatments." | 8.02 | Clinical and biochemical outcome of a patient with pyridoxine-dependent epilepsy treated by triple therapy (pyridoxine supplementation, lysine-restricted diet, and arginine supplementation). ( Benoist, JF; Mention, K; Minet, P; Miret, A; Remerand, G; Sarret, C, 2021) |
| "Using our laboratory database, we identified patients with vitamin B6-dependent epilepsy and extracted their data on the concentrations of pyridoxal 5'-phosphate, pyridoxal, pipecolic acid, α-aminoadipic semialdehyde, and monoamine neurotransmitters." | 7.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| "The measurements of lysine metabolites provide valuable information for the rapid diagnosis of pyridoxine-dependent epilepsy (PDE)." | 7.91 | Simultaneous quantification of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate, pipecolic acid and alpha-aminoadipic acid in pyridoxine-dependent epilepsy. ( Gong, P; Jiang, S; Jiang, Y; Li, H; Wang, J; Wu, M; Wu, Y; Xue, J; Yang, W; Yang, Z; Yuzyuk, T; Zhang, Y, 2019) |
| "Pyridoxine-Dependent Epilepsy (PDE) is a recessive disorder caused by deficiency of α-aminoadipic semialdehyde dehydrogenase in the catabolic pathway of lysine." | 7.83 | Effect of dietary lysine restriction and arginine supplementation in two patients with pyridoxine-dependent epilepsy. ( Botto, LD; De Biase, I; Liu, A; Longo, N; Pasquali, M; Thomas, A; Viau, K; Yuzyuk, T, 2016) |
| "To analyze the clinical and genetic characteristics of patients with pyridoxine dependent epilepsy (PDE), and build a method to detect and analyze the concentration of urinary pipecolic acid in PDE patients receiving pyridoxine treatment." | 7.83 | [Clinical and genetic characteristics and detection of urinary pipecolic acid in pyridoxine dependent epilepsy]. ( Jiang, YW; Li, H; Liu, XY; Qian, P; Wu, Y; Xue, J; Yang, ZX, 2016) |
| "To evaluate the efficacy and safety of dietary lysine restriction as an adjunct to pyridoxine therapy on biochemical parameters, seizure control, and developmental/cognitive outcomes in children with pyridoxine-dependent epilepsy (PDE) caused by antiquitin (ATQ) deficiency." | 7.78 | Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials. ( Bok, LA; Cheng, B; Collet, JP; Connolly, M; Coughlin, CR; Das, AM; Gospe, SM; Hartmann, H; Jaggumantri, S; Jakobs, C; Mercimek-Mahmutoglu, S; Meyer, U; Plecko, BR; Sinclair, G; Stockler, S; Struys, E; van der Lee, JH; Van Hove, J; van Karnebeek, CD, 2012) |
| "Pyridoxine-dependent epilepsy, although described some decades ago, may still be an underdiagnosed disorder." | 7.73 | Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. ( Baumeister, F; Baumgartner, M; Erwa, W; Hikel, C; Jakobs, C; Korenke, GC; Plecko, B; Schmitt, B; Stöckler-Ipsiroglu, S; Struys, E, 2005) |
| "Diagnosis of pyridoxine-dependent epilepsy is based on the clinical response to high-dosage application of pyridoxine." | 7.70 | Pipecolic acid elevation in plasma and cerebrospinal fluid of two patients with pyridoxine-dependent epilepsy. ( Erwa, W; Jakobs, C; Paschke, E; Plecko, B; Stöckler-Ipsiroglu, S; Struys, EA, 2000) |
| "Tiagabine has comparable anticonvulsant action to carbamazepine in rats and has anticonvulsant effects in non-human primates supporting the potential use of inhibitors of GABA uptake as therapy for epilepsy." | 5.29 | The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy. ( Chapman, AG; Meldrum, BS; Parvez, NS; Smith, SE, 1995) |
| "Pyridoxine-dependent epilepsy (PDE) is a recessive genetic disease characterized by epileptic encephalopathy with therapeutic response to pharmacological doses of pyridoxine and resistance to anti-epileptic treatments." | 4.02 | Clinical and biochemical outcome of a patient with pyridoxine-dependent epilepsy treated by triple therapy (pyridoxine supplementation, lysine-restricted diet, and arginine supplementation). ( Benoist, JF; Mention, K; Minet, P; Miret, A; Remerand, G; Sarret, C, 2021) |
| "Using our laboratory database, we identified patients with vitamin B6-dependent epilepsy and extracted their data on the concentrations of pyridoxal 5'-phosphate, pyridoxal, pipecolic acid, α-aminoadipic semialdehyde, and monoamine neurotransmitters." | 3.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| "The measurements of lysine metabolites provide valuable information for the rapid diagnosis of pyridoxine-dependent epilepsy (PDE)." | 3.91 | Simultaneous quantification of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate, pipecolic acid and alpha-aminoadipic acid in pyridoxine-dependent epilepsy. ( Gong, P; Jiang, S; Jiang, Y; Li, H; Wang, J; Wu, M; Wu, Y; Xue, J; Yang, W; Yang, Z; Yuzyuk, T; Zhang, Y, 2019) |
| "Pyridoxine-Dependent Epilepsy (PDE) is a recessive disorder caused by deficiency of α-aminoadipic semialdehyde dehydrogenase in the catabolic pathway of lysine." | 3.83 | Effect of dietary lysine restriction and arginine supplementation in two patients with pyridoxine-dependent epilepsy. ( Botto, LD; De Biase, I; Liu, A; Longo, N; Pasquali, M; Thomas, A; Viau, K; Yuzyuk, T, 2016) |
| "To analyze the clinical and genetic characteristics of patients with pyridoxine dependent epilepsy (PDE), and build a method to detect and analyze the concentration of urinary pipecolic acid in PDE patients receiving pyridoxine treatment." | 3.83 | [Clinical and genetic characteristics and detection of urinary pipecolic acid in pyridoxine dependent epilepsy]. ( Jiang, YW; Li, H; Liu, XY; Qian, P; Wu, Y; Xue, J; Yang, ZX, 2016) |
| "Pipecolic acid (PA) is an important biochemical marker for the diagnosis of peroxisomal disorders." | 3.81 | Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method. ( Barraco, GM; Boenzi, S; Catesini, G; Dionisi-Vici, C; Iacovone, F; Inglese, R; Manco, M; Muraca, M; Rizzo, C; Semeraro, M, 2015) |
| "To evaluate the efficacy and safety of dietary lysine restriction as an adjunct to pyridoxine therapy on biochemical parameters, seizure control, and developmental/cognitive outcomes in children with pyridoxine-dependent epilepsy (PDE) caused by antiquitin (ATQ) deficiency." | 3.78 | Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials. ( Bok, LA; Cheng, B; Collet, JP; Connolly, M; Coughlin, CR; Das, AM; Gospe, SM; Hartmann, H; Jaggumantri, S; Jakobs, C; Mercimek-Mahmutoglu, S; Meyer, U; Plecko, BR; Sinclair, G; Stockler, S; Struys, E; van der Lee, JH; Van Hove, J; van Karnebeek, CD, 2012) |
| "Pyridoxine-dependent epilepsy, although described some decades ago, may still be an underdiagnosed disorder." | 3.73 | Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. ( Baumeister, F; Baumgartner, M; Erwa, W; Hikel, C; Jakobs, C; Korenke, GC; Plecko, B; Schmitt, B; Stöckler-Ipsiroglu, S; Struys, E, 2005) |
| "Elevated concentrations of pipecolic acid have been reported in plasma and CSF of patients with pyridoxine-dependent epilepsy, but its molecular background is unclear." | 3.73 | Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine-deficient rats. ( Hoeger, H; Jakobs, C; Leschnik, M; Muehl, A; Plecko, B; Stoeckler-Ipsiroglu, S; Stromberger, C; Struys, E, 2005) |
| "Diagnosis of pyridoxine-dependent epilepsy is based on the clinical response to high-dosage application of pyridoxine." | 3.70 | Pipecolic acid elevation in plasma and cerebrospinal fluid of two patients with pyridoxine-dependent epilepsy. ( Erwa, W; Jakobs, C; Paschke, E; Plecko, B; Stöckler-Ipsiroglu, S; Struys, EA, 2000) |
| "Tiagabine has comparable anticonvulsant action to carbamazepine in rats and has anticonvulsant effects in non-human primates supporting the potential use of inhibitors of GABA uptake as therapy for epilepsy." | 1.29 | The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy. ( Chapman, AG; Meldrum, BS; Parvez, NS; Smith, SE, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 8 (44.44) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Smith, SE | 1 |
| Parvez, NS | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 1 |
| Pfeiffer, M | 1 |
| Draguhn, A | 1 |
| Meierkord, H | 1 |
| Heinemann, U | 1 |
| Mathis, D | 3 |
| Beese, K | 1 |
| Rüegg, C | 1 |
| Plecko, B | 6 |
| Hersberger, M | 1 |
| Akiyama, T | 1 |
| Hyodo, Y | 1 |
| Hasegawa, K | 1 |
| Oboshi, T | 1 |
| Imai, K | 1 |
| Ishihara, N | 1 |
| Dowa, Y | 1 |
| Koike, T | 1 |
| Yamamoto, T | 1 |
| Shibasaki, J | 1 |
| Shimbo, H | 1 |
| Fukuyama, T | 1 |
| Takano, K | 1 |
| Shiraku, H | 1 |
| Takeshita, S | 1 |
| Okanishi, T | 1 |
| Baba, S | 1 |
| Kubota, M | 1 |
| Hamano, SI | 1 |
| Kobayashi, K | 1 |
| Minet, P | 1 |
| Sarret, C | 1 |
| Miret, A | 1 |
| Mention, K | 1 |
| Benoist, JF | 1 |
| Remerand, G | 1 |
| Srinivasaraghavan, R | 1 |
| Parameswaran, N | 1 |
| Bürer, C | 1 |
| Crowther, LM | 1 |
| Poms, M | 1 |
| Xue, J | 2 |
| Wang, J | 1 |
| Gong, P | 1 |
| Wu, M | 1 |
| Yang, W | 1 |
| Jiang, S | 1 |
| Wu, Y | 2 |
| Jiang, Y | 1 |
| Zhang, Y | 1 |
| Yuzyuk, T | 2 |
| Li, H | 2 |
| Yang, Z | 1 |
| Semeraro, M | 1 |
| Muraca, M | 1 |
| Catesini, G | 1 |
| Inglese, R | 1 |
| Iacovone, F | 1 |
| Barraco, GM | 1 |
| Manco, M | 1 |
| Boenzi, S | 1 |
| Dionisi-Vici, C | 1 |
| Rizzo, C | 1 |
| Leganés-Ramos, A | 1 |
| Álvaro-Alonso, EA | 1 |
| Martín de Rosales-Cabrera, AM | 1 |
| Pérez-Encinas, M | 1 |
| Thomas, A | 1 |
| Viau, K | 1 |
| Liu, A | 1 |
| De Biase, I | 1 |
| Botto, LD | 1 |
| Pasquali, M | 1 |
| Longo, N | 1 |
| Yang, ZX | 1 |
| Qian, P | 1 |
| Jiang, YW | 1 |
| Liu, XY | 1 |
| van Karnebeek, CD | 1 |
| Hartmann, H | 1 |
| Jaggumantri, S | 1 |
| Bok, LA | 1 |
| Cheng, B | 1 |
| Connolly, M | 1 |
| Coughlin, CR | 1 |
| Das, AM | 1 |
| Gospe, SM | 1 |
| Jakobs, C | 5 |
| van der Lee, JH | 1 |
| Mercimek-Mahmutoglu, S | 1 |
| Meyer, U | 1 |
| Struys, E | 3 |
| Sinclair, G | 1 |
| Van Hove, J | 1 |
| Collet, JP | 1 |
| Plecko, BR | 1 |
| Stockler, S | 1 |
| Hikel, C | 1 |
| Korenke, GC | 1 |
| Schmitt, B | 1 |
| Baumgartner, M | 1 |
| Baumeister, F | 1 |
| Erwa, W | 2 |
| Stöckler-Ipsiroglu, S | 2 |
| Hoeger, H | 1 |
| Stromberger, C | 1 |
| Leschnik, M | 1 |
| Muehl, A | 1 |
| Stoeckler-Ipsiroglu, S | 1 |
| Willemsen, MA | 1 |
| Mavinkurve-Groothuis, AM | 1 |
| Wevers, RA | 1 |
| Rotteveel, JJ | 1 |
| Paschke, E | 1 |
| Struys, EA | 1 |
| Barth, PG | 1 |
| Schutgens, RB | 1 |
| Bakkeren, JA | 1 |
| Dingemans, KP | 1 |
| Heymans, HS | 1 |
| Douwes, AC | 1 |
| van der Klei-van Moorsel, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neurodevelopmental Outcome of Early Dietary Lysine Restriction in Pyridoxine[NCT01795170] | 0 participants (Actual) | Observational | 2013-04-30 | Withdrawn (stopped due to The study couldn't be initiated as we did not secure funding.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 other studies available for pipecolic acid and Epilepsy
| Article | Year |
|---|---|
The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Epilepsy; Female; G | 1995 |
Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Entorhinal Cortex; Epilepsy; Female; GABA Agoni | 1996 |
LC-MS/MS method for the differential diagnosis of treatable early onset inherited metabolic epilepsies.
Topics: Aldehyde Dehydrogenase; Biomarkers; Chromatography, Liquid; Diagnosis, Differential; Epilepsy; Human | 2020 |
Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate.
Topics: 5-Hydroxytryptophan; Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, | 2020 |
Clinical and biochemical outcome of a patient with pyridoxine-dependent epilepsy treated by triple therapy (pyridoxine supplementation, lysine-restricted diet, and arginine supplementation).
Topics: Arginine; Biomarkers; Child, Preschool; Dietary Supplements; Epilepsy; Female; Humans; Lysine; Pipec | 2021 |
Antiquitin Deficiency with Adolescent Onset Epilepsy: Molecular Diagnosis in a Mother of Affected Offsprings.
Topics: Age of Onset; Aldehyde Dehydrogenase; Epilepsy; Humans; Magnetic Resonance Imaging; Male; Metabolic | 2018 |
New insights into human lysine degradation pathways with relevance to pyridoxine-dependent epilepsy due to antiquitin deficiency.
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Epilepsy; Humans; Lysine; Metabolic Networks and Pathway | 2019 |
Simultaneous quantification of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate, pipecolic acid and alpha-aminoadipic acid in pyridoxine-dependent epilepsy.
Topics: 2-Aminoadipic Acid; Biomarkers; Child; Child, Preschool; Chromatography, Liquid; Epilepsy; Female; H | 2019 |
Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method.
Topics: Adolescent; Adult; Biomarkers; Calibration; Child; Child, Preschool; Chromatography, High Pressure L | 2015 |
Oral formulation of pyridoxine for the treatment of pyridoxinedependent epilepsy in a paediatric patient.
Topics: Drug Compounding; Epilepsy; Female; Humans; Hyperlysinemias; Infant, Newborn; Pipecolic Acids; Pyrid | 2016 |
Effect of dietary lysine restriction and arginine supplementation in two patients with pyridoxine-dependent epilepsy.
Topics: Arginine; Biomarkers; Child, Preschool; Dietary Supplements; Epilepsy; Female; Humans; Infant; Lysin | 2016 |
[Clinical and genetic characteristics and detection of urinary pipecolic acid in pyridoxine dependent epilepsy].
Topics: Aldehyde Dehydrogenase; Asian People; Child; Child, Preschool; Delayed Diagnosis; DNA Mutational Ana | 2016 |
Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials.
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Child; Child, Preschool; Cognition; Diet; Epilepsy; Fema | 2012 |
Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy.
Topics: Anticonvulsants; Biomarkers; Brain; Epilepsy; Humans; Infant; Infant, Newborn; Pipecolic Acids; Pyri | 2005 |
Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine-deficient rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Brain; Disease Models, Animal; Epilepsy; Female | 2005 |
Pipecolic acid: a diagnostic marker in pyridoxine-dependent epilepsy.
Topics: Child; Electroencephalography; Epilepsy; Follow-Up Studies; Humans; Male; Pipecolic Acids; Pyridoxin | 2005 |
Pipecolic acid elevation in plasma and cerebrospinal fluid of two patients with pyridoxine-dependent epilepsy.
Topics: 2-Aminoadipic Acid; Child; Epilepsy; Humans; Infant, Newborn; Male; Picolinic Acids; Pipecolic Acids | 2000 |
A milder variant of Zellweger syndrome.
Topics: Abnormalities, Multiple; Biopsy; Child, Preschool; Choroid; Epilepsy; Facial Bones; Genes, Recessive | 1985 |