pipecolic acid has been researched along with Aura in 18 studies
pipecolic acid: RN given refers to cpd without isomeric designation
pipecolic acid : A piperidinemonocarboxylic acid in which the carboxy group is located at position C-2.
pipecolate : A piperidinecarboxylate that is the conjugate base of pipecolic acid.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pyridoxine-dependent epilepsy (PDE) is a recessive genetic disease characterized by epileptic encephalopathy with therapeutic response to pharmacological doses of pyridoxine and resistance to anti-epileptic treatments." | 8.02 | Clinical and biochemical outcome of a patient with pyridoxine-dependent epilepsy treated by triple therapy (pyridoxine supplementation, lysine-restricted diet, and arginine supplementation). ( Benoist, JF; Mention, K; Minet, P; Miret, A; Remerand, G; Sarret, C, 2021) |
| "Using our laboratory database, we identified patients with vitamin B6-dependent epilepsy and extracted their data on the concentrations of pyridoxal 5'-phosphate, pyridoxal, pipecolic acid, α-aminoadipic semialdehyde, and monoamine neurotransmitters." | 7.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| "The measurements of lysine metabolites provide valuable information for the rapid diagnosis of pyridoxine-dependent epilepsy (PDE)." | 7.91 | Simultaneous quantification of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate, pipecolic acid and alpha-aminoadipic acid in pyridoxine-dependent epilepsy. ( Gong, P; Jiang, S; Jiang, Y; Li, H; Wang, J; Wu, M; Wu, Y; Xue, J; Yang, W; Yang, Z; Yuzyuk, T; Zhang, Y, 2019) |
| "Pyridoxine-Dependent Epilepsy (PDE) is a recessive disorder caused by deficiency of α-aminoadipic semialdehyde dehydrogenase in the catabolic pathway of lysine." | 7.83 | Effect of dietary lysine restriction and arginine supplementation in two patients with pyridoxine-dependent epilepsy. ( Botto, LD; De Biase, I; Liu, A; Longo, N; Pasquali, M; Thomas, A; Viau, K; Yuzyuk, T, 2016) |
| "To analyze the clinical and genetic characteristics of patients with pyridoxine dependent epilepsy (PDE), and build a method to detect and analyze the concentration of urinary pipecolic acid in PDE patients receiving pyridoxine treatment." | 7.83 | [Clinical and genetic characteristics and detection of urinary pipecolic acid in pyridoxine dependent epilepsy]. ( Jiang, YW; Li, H; Liu, XY; Qian, P; Wu, Y; Xue, J; Yang, ZX, 2016) |
| "To evaluate the efficacy and safety of dietary lysine restriction as an adjunct to pyridoxine therapy on biochemical parameters, seizure control, and developmental/cognitive outcomes in children with pyridoxine-dependent epilepsy (PDE) caused by antiquitin (ATQ) deficiency." | 7.78 | Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials. ( Bok, LA; Cheng, B; Collet, JP; Connolly, M; Coughlin, CR; Das, AM; Gospe, SM; Hartmann, H; Jaggumantri, S; Jakobs, C; Mercimek-Mahmutoglu, S; Meyer, U; Plecko, BR; Sinclair, G; Stockler, S; Struys, E; van der Lee, JH; Van Hove, J; van Karnebeek, CD, 2012) |
| "Pyridoxine-dependent epilepsy, although described some decades ago, may still be an underdiagnosed disorder." | 7.73 | Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. ( Baumeister, F; Baumgartner, M; Erwa, W; Hikel, C; Jakobs, C; Korenke, GC; Plecko, B; Schmitt, B; Stöckler-Ipsiroglu, S; Struys, E, 2005) |
| "Diagnosis of pyridoxine-dependent epilepsy is based on the clinical response to high-dosage application of pyridoxine." | 7.70 | Pipecolic acid elevation in plasma and cerebrospinal fluid of two patients with pyridoxine-dependent epilepsy. ( Erwa, W; Jakobs, C; Paschke, E; Plecko, B; Stöckler-Ipsiroglu, S; Struys, EA, 2000) |
| "Tiagabine has comparable anticonvulsant action to carbamazepine in rats and has anticonvulsant effects in non-human primates supporting the potential use of inhibitors of GABA uptake as therapy for epilepsy." | 5.29 | The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy. ( Chapman, AG; Meldrum, BS; Parvez, NS; Smith, SE, 1995) |
| "Pyridoxine-dependent epilepsy (PDE) is a recessive genetic disease characterized by epileptic encephalopathy with therapeutic response to pharmacological doses of pyridoxine and resistance to anti-epileptic treatments." | 4.02 | Clinical and biochemical outcome of a patient with pyridoxine-dependent epilepsy treated by triple therapy (pyridoxine supplementation, lysine-restricted diet, and arginine supplementation). ( Benoist, JF; Mention, K; Minet, P; Miret, A; Remerand, G; Sarret, C, 2021) |
| "Using our laboratory database, we identified patients with vitamin B6-dependent epilepsy and extracted their data on the concentrations of pyridoxal 5'-phosphate, pyridoxal, pipecolic acid, α-aminoadipic semialdehyde, and monoamine neurotransmitters." | 3.96 | Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate. ( Akiyama, T; Baba, S; Dowa, Y; Fukuyama, T; Hamano, SI; Hasegawa, K; Hyodo, Y; Imai, K; Ishihara, N; Kobayashi, K; Koike, T; Kubota, M; Oboshi, T; Okanishi, T; Shibasaki, J; Shimbo, H; Shiraku, H; Takano, K; Takeshita, S; Yamamoto, T, 2020) |
| "The measurements of lysine metabolites provide valuable information for the rapid diagnosis of pyridoxine-dependent epilepsy (PDE)." | 3.91 | Simultaneous quantification of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate, pipecolic acid and alpha-aminoadipic acid in pyridoxine-dependent epilepsy. ( Gong, P; Jiang, S; Jiang, Y; Li, H; Wang, J; Wu, M; Wu, Y; Xue, J; Yang, W; Yang, Z; Yuzyuk, T; Zhang, Y, 2019) |
| "Pyridoxine-Dependent Epilepsy (PDE) is a recessive disorder caused by deficiency of α-aminoadipic semialdehyde dehydrogenase in the catabolic pathway of lysine." | 3.83 | Effect of dietary lysine restriction and arginine supplementation in two patients with pyridoxine-dependent epilepsy. ( Botto, LD; De Biase, I; Liu, A; Longo, N; Pasquali, M; Thomas, A; Viau, K; Yuzyuk, T, 2016) |
| "To analyze the clinical and genetic characteristics of patients with pyridoxine dependent epilepsy (PDE), and build a method to detect and analyze the concentration of urinary pipecolic acid in PDE patients receiving pyridoxine treatment." | 3.83 | [Clinical and genetic characteristics and detection of urinary pipecolic acid in pyridoxine dependent epilepsy]. ( Jiang, YW; Li, H; Liu, XY; Qian, P; Wu, Y; Xue, J; Yang, ZX, 2016) |
| "Pipecolic acid (PA) is an important biochemical marker for the diagnosis of peroxisomal disorders." | 3.81 | Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method. ( Barraco, GM; Boenzi, S; Catesini, G; Dionisi-Vici, C; Iacovone, F; Inglese, R; Manco, M; Muraca, M; Rizzo, C; Semeraro, M, 2015) |
| "To evaluate the efficacy and safety of dietary lysine restriction as an adjunct to pyridoxine therapy on biochemical parameters, seizure control, and developmental/cognitive outcomes in children with pyridoxine-dependent epilepsy (PDE) caused by antiquitin (ATQ) deficiency." | 3.78 | Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials. ( Bok, LA; Cheng, B; Collet, JP; Connolly, M; Coughlin, CR; Das, AM; Gospe, SM; Hartmann, H; Jaggumantri, S; Jakobs, C; Mercimek-Mahmutoglu, S; Meyer, U; Plecko, BR; Sinclair, G; Stockler, S; Struys, E; van der Lee, JH; Van Hove, J; van Karnebeek, CD, 2012) |
| "Pyridoxine-dependent epilepsy, although described some decades ago, may still be an underdiagnosed disorder." | 3.73 | Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy. ( Baumeister, F; Baumgartner, M; Erwa, W; Hikel, C; Jakobs, C; Korenke, GC; Plecko, B; Schmitt, B; Stöckler-Ipsiroglu, S; Struys, E, 2005) |
| "Elevated concentrations of pipecolic acid have been reported in plasma and CSF of patients with pyridoxine-dependent epilepsy, but its molecular background is unclear." | 3.73 | Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine-deficient rats. ( Hoeger, H; Jakobs, C; Leschnik, M; Muehl, A; Plecko, B; Stoeckler-Ipsiroglu, S; Stromberger, C; Struys, E, 2005) |
| "Diagnosis of pyridoxine-dependent epilepsy is based on the clinical response to high-dosage application of pyridoxine." | 3.70 | Pipecolic acid elevation in plasma and cerebrospinal fluid of two patients with pyridoxine-dependent epilepsy. ( Erwa, W; Jakobs, C; Paschke, E; Plecko, B; Stöckler-Ipsiroglu, S; Struys, EA, 2000) |
| "Tiagabine has comparable anticonvulsant action to carbamazepine in rats and has anticonvulsant effects in non-human primates supporting the potential use of inhibitors of GABA uptake as therapy for epilepsy." | 1.29 | The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy. ( Chapman, AG; Meldrum, BS; Parvez, NS; Smith, SE, 1995) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.56) | 18.7374 |
| 1990's | 2 (11.11) | 18.2507 |
| 2000's | 4 (22.22) | 29.6817 |
| 2010's | 8 (44.44) | 24.3611 |
| 2020's | 3 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Smith, SE | 1 |
| Parvez, NS | 1 |
| Chapman, AG | 1 |
| Meldrum, BS | 1 |
| Pfeiffer, M | 1 |
| Draguhn, A | 1 |
| Meierkord, H | 1 |
| Heinemann, U | 1 |
| Mathis, D | 3 |
| Beese, K | 1 |
| Rüegg, C | 1 |
| Plecko, B | 6 |
| Hersberger, M | 1 |
| Akiyama, T | 1 |
| Hyodo, Y | 1 |
| Hasegawa, K | 1 |
| Oboshi, T | 1 |
| Imai, K | 1 |
| Ishihara, N | 1 |
| Dowa, Y | 1 |
| Koike, T | 1 |
| Yamamoto, T | 1 |
| Shibasaki, J | 1 |
| Shimbo, H | 1 |
| Fukuyama, T | 1 |
| Takano, K | 1 |
| Shiraku, H | 1 |
| Takeshita, S | 1 |
| Okanishi, T | 1 |
| Baba, S | 1 |
| Kubota, M | 1 |
| Hamano, SI | 1 |
| Kobayashi, K | 1 |
| Minet, P | 1 |
| Sarret, C | 1 |
| Miret, A | 1 |
| Mention, K | 1 |
| Benoist, JF | 1 |
| Remerand, G | 1 |
| Srinivasaraghavan, R | 1 |
| Parameswaran, N | 1 |
| Bürer, C | 1 |
| Crowther, LM | 1 |
| Poms, M | 1 |
| Xue, J | 2 |
| Wang, J | 1 |
| Gong, P | 1 |
| Wu, M | 1 |
| Yang, W | 1 |
| Jiang, S | 1 |
| Wu, Y | 2 |
| Jiang, Y | 1 |
| Zhang, Y | 1 |
| Yuzyuk, T | 2 |
| Li, H | 2 |
| Yang, Z | 1 |
| Semeraro, M | 1 |
| Muraca, M | 1 |
| Catesini, G | 1 |
| Inglese, R | 1 |
| Iacovone, F | 1 |
| Barraco, GM | 1 |
| Manco, M | 1 |
| Boenzi, S | 1 |
| Dionisi-Vici, C | 1 |
| Rizzo, C | 1 |
| Leganés-Ramos, A | 1 |
| Álvaro-Alonso, EA | 1 |
| Martín de Rosales-Cabrera, AM | 1 |
| Pérez-Encinas, M | 1 |
| Thomas, A | 1 |
| Viau, K | 1 |
| Liu, A | 1 |
| De Biase, I | 1 |
| Botto, LD | 1 |
| Pasquali, M | 1 |
| Longo, N | 1 |
| Yang, ZX | 1 |
| Qian, P | 1 |
| Jiang, YW | 1 |
| Liu, XY | 1 |
| van Karnebeek, CD | 1 |
| Hartmann, H | 1 |
| Jaggumantri, S | 1 |
| Bok, LA | 1 |
| Cheng, B | 1 |
| Connolly, M | 1 |
| Coughlin, CR | 1 |
| Das, AM | 1 |
| Gospe, SM | 1 |
| Jakobs, C | 5 |
| van der Lee, JH | 1 |
| Mercimek-Mahmutoglu, S | 1 |
| Meyer, U | 1 |
| Struys, E | 3 |
| Sinclair, G | 1 |
| Van Hove, J | 1 |
| Collet, JP | 1 |
| Plecko, BR | 1 |
| Stockler, S | 1 |
| Hikel, C | 1 |
| Korenke, GC | 1 |
| Schmitt, B | 1 |
| Baumgartner, M | 1 |
| Baumeister, F | 1 |
| Erwa, W | 2 |
| Stöckler-Ipsiroglu, S | 2 |
| Hoeger, H | 1 |
| Stromberger, C | 1 |
| Leschnik, M | 1 |
| Muehl, A | 1 |
| Stoeckler-Ipsiroglu, S | 1 |
| Willemsen, MA | 1 |
| Mavinkurve-Groothuis, AM | 1 |
| Wevers, RA | 1 |
| Rotteveel, JJ | 1 |
| Paschke, E | 1 |
| Struys, EA | 1 |
| Barth, PG | 1 |
| Schutgens, RB | 1 |
| Bakkeren, JA | 1 |
| Dingemans, KP | 1 |
| Heymans, HS | 1 |
| Douwes, AC | 1 |
| van der Klei-van Moorsel, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neurodevelopmental Outcome of Early Dietary Lysine Restriction in Pyridoxine[NCT01795170] | 0 participants (Actual) | Observational | 2013-04-30 | Withdrawn (stopped due to The study couldn't be initiated as we did not secure funding.) | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
18 other studies available for pipecolic acid and Aura
| Article | Year |
|---|---|
The gamma-aminobutyric acid uptake inhibitor, tiagabine, is anticonvulsant in two animal models of reflex epilepsy.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Behavior, Animal; Carbamazepine; Epilepsy; Female; G | 1995 |
Effects of gamma-aminobutyric acid (GABA) agonists and GABA uptake inhibitors on pharmacosensitive and pharmacoresistant epileptiform activity in vitro.
Topics: Animals; Baclofen; Dose-Response Relationship, Drug; Entorhinal Cortex; Epilepsy; Female; GABA Agoni | 1996 |
LC-MS/MS method for the differential diagnosis of treatable early onset inherited metabolic epilepsies.
Topics: Aldehyde Dehydrogenase; Biomarkers; Chromatography, Liquid; Diagnosis, Differential; Epilepsy; Human | 2020 |
Pyridoxal in the Cerebrospinal Fluid May Be a Better Indicator of Vitamin B6-dependent Epilepsy Than Pyridoxal 5'-Phosphate.
Topics: 5-Hydroxytryptophan; Adolescent; Child; Child, Preschool; Epilepsy; Female; Humans; Infant; Infant, | 2020 |
Clinical and biochemical outcome of a patient with pyridoxine-dependent epilepsy treated by triple therapy (pyridoxine supplementation, lysine-restricted diet, and arginine supplementation).
Topics: Arginine; Biomarkers; Child, Preschool; Dietary Supplements; Epilepsy; Female; Humans; Lysine; Pipec | 2021 |
Antiquitin Deficiency with Adolescent Onset Epilepsy: Molecular Diagnosis in a Mother of Affected Offsprings.
Topics: Age of Onset; Aldehyde Dehydrogenase; Epilepsy; Humans; Magnetic Resonance Imaging; Male; Metabolic | 2018 |
New insights into human lysine degradation pathways with relevance to pyridoxine-dependent epilepsy due to antiquitin deficiency.
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Epilepsy; Humans; Lysine; Metabolic Networks and Pathway | 2019 |
Simultaneous quantification of alpha-aminoadipic semialdehyde, piperideine-6-carboxylate, pipecolic acid and alpha-aminoadipic acid in pyridoxine-dependent epilepsy.
Topics: 2-Aminoadipic Acid; Biomarkers; Child; Child, Preschool; Chromatography, Liquid; Epilepsy; Female; H | 2019 |
Determination of plasma pipecolic acid by an easy and rapid liquid chromatography-tandem mass spectrometry method.
Topics: Adolescent; Adult; Biomarkers; Calibration; Child; Child, Preschool; Chromatography, High Pressure L | 2015 |
Oral formulation of pyridoxine for the treatment of pyridoxinedependent epilepsy in a paediatric patient.
Topics: Drug Compounding; Epilepsy; Female; Humans; Hyperlysinemias; Infant, Newborn; Pipecolic Acids; Pyrid | 2016 |
Effect of dietary lysine restriction and arginine supplementation in two patients with pyridoxine-dependent epilepsy.
Topics: Arginine; Biomarkers; Child, Preschool; Dietary Supplements; Epilepsy; Female; Humans; Infant; Lysin | 2016 |
[Clinical and genetic characteristics and detection of urinary pipecolic acid in pyridoxine dependent epilepsy].
Topics: Aldehyde Dehydrogenase; Asian People; Child; Child, Preschool; Delayed Diagnosis; DNA Mutational Ana | 2016 |
Lysine restricted diet for pyridoxine-dependent epilepsy: first evidence and future trials.
Topics: 2-Aminoadipic Acid; Aldehyde Dehydrogenase; Child; Child, Preschool; Cognition; Diet; Epilepsy; Fema | 2012 |
Pipecolic acid as a diagnostic marker of pyridoxine-dependent epilepsy.
Topics: Anticonvulsants; Biomarkers; Brain; Epilepsy; Humans; Infant; Infant, Newborn; Pipecolic Acids; Pyri | 2005 |
Pipecolic acid concentrations in brain tissue of nutritionally pyridoxine-deficient rats.
Topics: Animal Nutritional Physiological Phenomena; Animals; Brain; Disease Models, Animal; Epilepsy; Female | 2005 |
Pipecolic acid: a diagnostic marker in pyridoxine-dependent epilepsy.
Topics: Child; Electroencephalography; Epilepsy; Follow-Up Studies; Humans; Male; Pipecolic Acids; Pyridoxin | 2005 |
Pipecolic acid elevation in plasma and cerebrospinal fluid of two patients with pyridoxine-dependent epilepsy.
Topics: 2-Aminoadipic Acid; Child; Epilepsy; Humans; Infant, Newborn; Male; Picolinic Acids; Pipecolic Acids | 2000 |
A milder variant of Zellweger syndrome.
Topics: Abnormalities, Multiple; Biopsy; Child, Preschool; Choroid; Epilepsy; Facial Bones; Genes, Recessive | 1985 |