pioglitazone has been researched along with Seizures in 9 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Neither KD treatment nor pioglitazone alone or in combination affected clonic seizures." | 7.85 | Synergistic protection against acute flurothyl-induced seizures by adjuvant treatment of the ketogenic diet with the type 2 diabetes drug pioglitazone. ( Matthews, SA; Simeone, KA; Simeone, TA, 2017) |
| "Taken together, sub-chronic pioglitazone treatment exerts anti-convulsant effects in intravenous and intraperitoneal pentylenetetrazole-induced seizures of mice probably through induction of constitutive nitric oxide synthase." | 7.78 | Sub-chronic treatment with pioglitazone exerts anti-convulsant effects in pentylenetetrazole-induced seizures of mice: The role of nitric oxide. ( Dehpour, AR; Ghorbani, H; Hassanipour, M; Hassanpour, S; Moezi, L; Shafaroodi, H; Zaeri, M, 2012) |
| "The present study demonstrates the anticonvulsant effect of acute pioglitazone on PTZ-induced seizures in mice." | 7.78 | Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in mice. ( Adabi Mohazab, R; Dehpour, AR; Delfan, B; Javadi-Paydar, M, 2012) |
| "Pioglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, is used in inflammatory brain diseases, and it was shown to protect against seizures in genetically epileptic mice." | 7.76 | Anticonvulsant potential of the peroxisome proliferator-activated receptor γ agonist pioglitazone in pentylenetetrazole-induced acute seizures and kindling in mice. ( Abdallah, DM, 2010) |
| "Epilepsy is one of the most common neurological disorders affecting most social, economic and biological aspects of human life." | 5.72 | Treatment of pilocarpine-induced epileptic seizures in adult male mice. ( Abdelbasset, WK; Huldani, H; Jalil, AT; Jasim, SA; Margiana, R; Mohammad, HJ; Ridha, HS; Rudiansyah, M; Yasin, G, 2022) |
| " The aim of the present study was to determine if modulation by PPAR-γ could attenuate pilocarpine-induced seizures and decrease neuronal excitability." | 3.91 | The Protective Role of Peroxisome Proliferator-Activated Receptor-Gamma in Seizure and Neuronal Excitotoxicity. ( Chu, FL; Huang, CW; Hung, TY; Wu, DC; Wu, SN, 2019) |
| "Neither KD treatment nor pioglitazone alone or in combination affected clonic seizures." | 3.85 | Synergistic protection against acute flurothyl-induced seizures by adjuvant treatment of the ketogenic diet with the type 2 diabetes drug pioglitazone. ( Matthews, SA; Simeone, KA; Simeone, TA, 2017) |
| "Taken together, sub-chronic pioglitazone treatment exerts anti-convulsant effects in intravenous and intraperitoneal pentylenetetrazole-induced seizures of mice probably through induction of constitutive nitric oxide synthase." | 3.78 | Sub-chronic treatment with pioglitazone exerts anti-convulsant effects in pentylenetetrazole-induced seizures of mice: The role of nitric oxide. ( Dehpour, AR; Ghorbani, H; Hassanipour, M; Hassanpour, S; Moezi, L; Shafaroodi, H; Zaeri, M, 2012) |
| "The present study demonstrates the anticonvulsant effect of acute pioglitazone on PTZ-induced seizures in mice." | 3.78 | Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in mice. ( Adabi Mohazab, R; Dehpour, AR; Delfan, B; Javadi-Paydar, M, 2012) |
| "Pioglitazone, a peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonist, is used in inflammatory brain diseases, and it was shown to protect against seizures in genetically epileptic mice." | 3.76 | Anticonvulsant potential of the peroxisome proliferator-activated receptor γ agonist pioglitazone in pentylenetetrazole-induced acute seizures and kindling in mice. ( Abdallah, DM, 2010) |
| "Epilepsy is one of the most common neurological disorders affecting most social, economic and biological aspects of human life." | 1.72 | Treatment of pilocarpine-induced epileptic seizures in adult male mice. ( Abdelbasset, WK; Huldani, H; Jalil, AT; Jasim, SA; Margiana, R; Mohammad, HJ; Ridha, HS; Rudiansyah, M; Yasin, G, 2022) |
| "Pretreatment with pioglitazone, as a PPARγ agonist, potentiated the anticonvulsant effects of WIN, while PPARγ antagonist inhibited these anticonvulsant effects partially." | 1.42 | Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2. ( Aghaei, HN; Dehpour, AR; Ebrahimi, A; Gholizadeh, R; Gooshe, M; Mousavizadeh, K; Payandemehr, B; Rahimian, R; Varastehmoradi, B, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 7 (77.78) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| Authors | Studies |
|---|---|
| Abdelbasset, WK | 1 |
| Jasim, SA | 1 |
| Rudiansyah, M | 1 |
| Huldani, H | 1 |
| Margiana, R | 1 |
| Jalil, AT | 1 |
| Mohammad, HJ | 1 |
| Ridha, HS | 1 |
| Yasin, G | 1 |
| Simeone, TA | 1 |
| Matthews, SA | 1 |
| Simeone, KA | 1 |
| Hung, TY | 1 |
| Chu, FL | 1 |
| Wu, DC | 1 |
| Wu, SN | 1 |
| Huang, CW | 1 |
| Payandemehr, B | 1 |
| Ebrahimi, A | 1 |
| Gholizadeh, R | 1 |
| Rahimian, R | 1 |
| Varastehmoradi, B | 1 |
| Gooshe, M | 1 |
| Aghaei, HN | 1 |
| Mousavizadeh, K | 1 |
| Dehpour, AR | 3 |
| Ching, J | 1 |
| Amiridis, S | 1 |
| Stylli, SS | 1 |
| Bjorksten, AR | 1 |
| Kountouri, N | 1 |
| Zheng, T | 1 |
| Paradiso, L | 1 |
| Luwor, RB | 1 |
| Morokoff, AP | 1 |
| O'Brien, TJ | 1 |
| Kaye, AH | 1 |
| Abdallah, DM | 1 |
| Shafaroodi, H | 1 |
| Moezi, L | 1 |
| Ghorbani, H | 1 |
| Zaeri, M | 1 |
| Hassanpour, S | 1 |
| Hassanipour, M | 1 |
| Adabi Mohazab, R | 1 |
| Javadi-Paydar, M | 1 |
| Delfan, B | 1 |
| Okada, K | 1 |
| Yamashita, U | 1 |
| Tsuji, S | 1 |
9 other studies available for pioglitazone and Seizures
| Article | Year |
|---|---|
Treatment of pilocarpine-induced epileptic seizures in adult male mice.
Topics: Animals; Antioxidants; Diabetes Mellitus, Type 2; Epilepsy; Humans; Male; Mice; Pilocarpine; Pioglit | 2022 |
Synergistic protection against acute flurothyl-induced seizures by adjuvant treatment of the ketogenic diet with the type 2 diabetes drug pioglitazone.
Topics: 3-Hydroxybutyric Acid; Animals; Blood Glucose; Body Weight; Convulsants; Diet, Ketogenic; Disease Mo | 2017 |
The Protective Role of Peroxisome Proliferator-Activated Receptor-Gamma in Seizure and Neuronal Excitotoxicity.
Topics: Animals; Blood Glucose; Blood-Brain Barrier; Hippocampus; Ion Channel Gating; Mice, Inbred C57BL; Ne | 2019 |
Involvement of PPAR receptors in the anticonvulsant effects of a cannabinoid agonist, WIN 55,212-2.
Topics: Anilides; Animals; Anticonvulsants; Benzoxazines; Cannabinoid Receptor Antagonists; Disease Models, | 2015 |
The peroxisome proliferator activated receptor gamma agonist pioglitazone increases functional expression of the glutamate transporter excitatory amino acid transporter 2 (EAAT2) in human glioblastoma cells.
Topics: Anilides; Animals; Brain; Brain Neoplasms; Cell Line, Tumor; Cell Survival; Dose-Response Relationsh | 2015 |
Anticonvulsant potential of the peroxisome proliferator-activated receptor γ agonist pioglitazone in pentylenetetrazole-induced acute seizures and kindling in mice.
Topics: Animals; Anticonvulsants; Kindling, Neurologic; Male; Mice; Pentylenetetrazole; Pioglitazone; PPAR g | 2010 |
Sub-chronic treatment with pioglitazone exerts anti-convulsant effects in pentylenetetrazole-induced seizures of mice: The role of nitric oxide.
Topics: Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Drug Administration Routes; | 2012 |
Possible involvement of PPAR-gamma receptor and nitric oxide pathway in the anticonvulsant effect of acute pioglitazone on pentylenetetrazole-induced seizures in mice.
Topics: Anilides; Animals; Anticonvulsants; Arginine; Convulsants; Dose-Response Relationship, Drug; Enzyme | 2012 |
Ameliorative effect of pioglitazone on seizure responses in genetically epilepsy-susceptible EL mice.
Topics: Animals; Anticonvulsants; Brain; Cyclooxygenase 2; Cytokines; Epilepsy; Gene Expression Regulation; | 2006 |