pioglitazone has been researched along with Pre-Eclampsia in 3 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Pre-Eclampsia: A complication of PREGNANCY, characterized by a complex of symptoms including maternal HYPERTENSION and PROTEINURIA with or without pathological EDEMA. Symptoms may range between mild and severe. Pre-eclampsia usually occurs after the 20th week of gestation, but may develop before this time in the presence of trophoblastic disease.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Considering the role of renin-angiotensin system (RAS) in maternal programming during PE, we investigated the hypothesis that gestational modulation of offensive (Angiotensin II, Ang II) and defensive (Ang 1-7) components of RAS alleviates cardiovascular hyperresponsiveness of weaning PE mothers to postpartum endotoxemia." | 4.12 | Dysregulated ACE/Ang II/Ang1-7 signaling provokes cardiovascular and inflammatory sequelae of endotoxemia in weaning preeclamptic rats. ( Abuiessa, SA; El-Gowelli, HM; El-Gowilly, SM; El-Mas, MM; Helmy, MM, 2022) |
| " Here, we used a model of HA pregnancy in mice to determine whether hypoxia-induced fetal growth restriction reduces placental PPAR-γ protein expression and placental vascularization and, if so, to evaluate the effectiveness of the selective PPAR-γ agonist pioglitazone (PIO) for preventing hypoxia-induced IUGR." | 3.91 | Pharmacological activation of peroxisome proliferator-activated receptor γ (PPAR-γ) protects against hypoxia-associated fetal growth restriction. ( Dodson, RB; Doyle, AS; Julian, CG; Lane, SL; Lorca, RA; Matarrazo, CJ; Moore, LG; Park, H; Rathi, H; Wolfson, GH, 2019) |
| "Catechol-O-methyltransferase (COMT) metabolizes 2-hydroxyestradiol into 2-methoxyestradiol (2-ME); COMT deficiency has shown to be associated with hypertension in men and preeclampsia, the disease associated with hypersensitivity of pressor response against angiotensin II (Ang II)." | 3.85 | Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II. ( Kanasaki, K; Kanasaki, M; Koya, D; Takeda, S; Ueki, N, 2017) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Abuiessa, SA | 1 |
| Helmy, MM | 1 |
| El-Gowelli, HM | 1 |
| El-Gowilly, SM | 1 |
| El-Mas, MM | 1 |
| Ueki, N | 1 |
| Kanasaki, K | 1 |
| Kanasaki, M | 1 |
| Takeda, S | 1 |
| Koya, D | 1 |
| Lane, SL | 1 |
| Dodson, RB | 1 |
| Doyle, AS | 1 |
| Park, H | 1 |
| Rathi, H | 1 |
| Matarrazo, CJ | 1 |
| Moore, LG | 1 |
| Lorca, RA | 1 |
| Wolfson, GH | 1 |
| Julian, CG | 1 |
3 other studies available for pioglitazone and Pre-Eclampsia
| Article | Year |
|---|---|
Dysregulated ACE/Ang II/Ang1-7 signaling provokes cardiovascular and inflammatory sequelae of endotoxemia in weaning preeclamptic rats.
Topics: Angiotensin II; Animals; Endotoxemia; Female; Humans; Losartan; Peptidyl-Dipeptidase A; Pioglitazone | 2022 |
Catechol-O-Methyltransferase Deficiency Leads to Hypersensitivity of the Pressor Response Against Angiotensin II.
Topics: Angiotensin II; Animals; Catechol O-Methyltransferase; Drug Hypersensitivity; Female; Hypertension; | 2017 |
Pharmacological activation of peroxisome proliferator-activated receptor γ (PPAR-γ) protects against hypoxia-associated fetal growth restriction.
Topics: Altitude Sickness; AMP-Activated Protein Kinases; Animals; Disease Models, Animal; Female; Fetal Gro | 2019 |