pioglitazone has been researched along with Liver Failure in 7 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Liver Failure: Severe inability of the LIVER to perform its normal metabolic functions, as evidenced by severe JAUNDICE and abnormal serum levels of AMMONIA; BILIRUBIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; LACTATE DEHYDROGENASES; and albumin/globulin ratio. (Blakiston's Gould Medical Dictionary, 4th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| " Liver failure associated with rosiglitazone or pioglitazone was defined as liver injury accompanied by hepatic encephalopathy, liver transplantation, placement on a liver transplant list, or death in which all other likely etiologies were excluded." | 7.75 | Case series of liver failure associated with rosiglitazone and pioglitazone. ( Barbehenn, E; Floyd, JS; Lurie, P; Wolfe, SM, 2009) |
| "The aim of this study was to assess the incidence of liver failure in association with antidiabetic treatment using pioglitazone vs." | 7.73 | Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazone. ( Iyer, S; Perez, A; Rajagopalan, R, 2005) |
| " Liver failure associated with rosiglitazone or pioglitazone was defined as liver injury accompanied by hepatic encephalopathy, liver transplantation, placement on a liver transplant list, or death in which all other likely etiologies were excluded." | 3.75 | Case series of liver failure associated with rosiglitazone and pioglitazone. ( Barbehenn, E; Floyd, JS; Lurie, P; Wolfe, SM, 2009) |
| "The aim of this study was to assess the incidence of liver failure in association with antidiabetic treatment using pioglitazone vs." | 3.73 | Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazone. ( Iyer, S; Perez, A; Rajagopalan, R, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 7 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Floyd, JS | 1 |
| Barbehenn, E | 1 |
| Lurie, P | 1 |
| Wolfe, SM | 1 |
| Osei, SY | 1 |
| Koro, CE | 1 |
| Cobitz, AR | 1 |
| Kolatkar, NS | 1 |
| Stender, M | 1 |
| Beiderbeck, AB | 1 |
| Sakaguchi, M | 1 |
| Farley-Hills, E | 1 |
| Sivasankar, R | 1 |
| Martin, M | 1 |
| Rajagopalan, R | 1 |
| Iyer, S | 1 |
| Perez, A | 1 |
| Gale, EA | 1 |
| Chase, MP | 1 |
| Yarze, JC | 1 |
1 review available for pioglitazone and Liver Failure
| Article | Year |
|---|---|
Lessons from the glitazones: a story of drug development.
Topics: Adverse Drug Reaction Reporting Systems; Chemical and Drug Induced Liver Injury; Chromans; Diabetes | 2001 |
6 other studies available for pioglitazone and Liver Failure
| Article | Year |
|---|---|
Case series of liver failure associated with rosiglitazone and pioglitazone.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Chemical and Drug Induced Liver Injury; Databases, Fa | 2009 |
Commentary on 'Case series of liver failure associated with rosiglitazone and pioglitazone' by Floyd et al.
Topics: Adverse Drug Reaction Reporting Systems; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, | 2009 |
Commentary on 'Case series of liver failure associated with rosiglitazone and pioglitazone' by James Floyd et al.
Topics: Adverse Drug Reaction Reporting Systems; Chemical and Drug Induced Liver Injury; Diabetes Mellitus, | 2009 |
Fatal liver failure associated with pioglitazone.
Topics: Fatal Outcome; Humans; Hypoglycemic Agents; Liver Failure; Male; Middle Aged; Pioglitazone; Thiazoli | 2004 |
Comparison of pioglitazone with other antidiabetic drugs for associated incidence of liver failure: no evidence of increased risk of liver failure with pioglitazone.
Topics: Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver In | 2005 |
Pioglitazone-associated fulminant hepatic failure.
Topics: Aged; Biopsy, Needle; Diabetes Mellitus, Type 2; Follow-Up Studies; Humans; Hypoglycemic Agents; Liv | 2002 |