pioglitazone has been researched along with Injury, Myocardial Reperfusion in 23 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The present investigation was designed to study the cardioprotective effects of nicorandil and pioglitazone preconditioning in myocardial ischemia/reperfusion-induced hemodynamic, biochemical and histological changes in rats." | 7.77 | Pharmacological preconditioning with nicorandil and pioglitazone attenuates myocardial ischemia/reperfusion injury in rats. ( Agha, AM; Ahmed, LA; Attia, AS; Salem, HA, 2011) |
| "The insulin-sensitizing drug pioglitazone has been reported to be protective against myocardial infarction." | 7.75 | Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction. ( Fujiwara, H; Fujiwara, T; Iwasa, M; Kawamura, I; Kobayashi, H; Minatoguchi, S; Nagashima, K; Narentuoya, B; Nishigaki, K; Sumi, S; Takemura, G; Ushikoshi, H; Yamaki, T; Yasuda, S, 2009) |
| "Pioglitazone (PIO) is a new class of anti-diabetic agent with an anti-inflammatory effect." | 6.76 | Effect of pretreatment with pioglitazone on reperfusion injury in diabetic patients with acute myocardial infarction. ( Abe, M; Kasahara, Y; Kataoka, Y; Kokubu, N; Otsuka, Y; Yagi, N, 2011) |
| "The present investigation was designed to study the cardioprotective effects of nicorandil and pioglitazone preconditioning in myocardial ischemia/reperfusion-induced hemodynamic, biochemical and histological changes in rats." | 3.77 | Pharmacological preconditioning with nicorandil and pioglitazone attenuates myocardial ischemia/reperfusion injury in rats. ( Agha, AM; Ahmed, LA; Attia, AS; Salem, HA, 2011) |
| "The insulin-sensitizing drug pioglitazone has been reported to be protective against myocardial infarction." | 3.75 | Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction. ( Fujiwara, H; Fujiwara, T; Iwasa, M; Kawamura, I; Kobayashi, H; Minatoguchi, S; Nagashima, K; Narentuoya, B; Nishigaki, K; Sumi, S; Takemura, G; Ushikoshi, H; Yamaki, T; Yasuda, S, 2009) |
| "We investigated the effects of ischemic preconditioning (IP) on reperfusion arrhythmias in type 2 diabetic rats as well as the effects of the insulin sensitizer pioglitazone." | 3.74 | The insulin sensitizer pioglitazone improves the deterioration of ischemic preconditioning in type 2 diabetes mellitus rats. ( Kawai, M; Mochizuki, S; Mori, C; Ogawa, K; Okazaki, F; Sasaki, H; Shimizu, M; Takatsuka, H; Taniguchi, I, 2007) |
| "Pioglitazone (PIO) is a new class of anti-diabetic agent with an anti-inflammatory effect." | 2.76 | Effect of pretreatment with pioglitazone on reperfusion injury in diabetic patients with acute myocardial infarction. ( Abe, M; Kasahara, Y; Kataoka, Y; Kokubu, N; Otsuka, Y; Yagi, N, 2011) |
| "Pioglitazone treatment significantly suppressed myocardial apoptosis (21." | 1.40 | [Effects of pioglitazone on myocardial peroxisome proliferator-activated receptor gamma co-activator lα expression in rats with myocardial ischemia/reperfusion injury]. ( Shen, L; Wang, H; Ye, P, 2014) |
| "Pioglitazone can inhibit the myocardial apoptosis induced by ischemia/reperfusion." | 1.39 | [Effects of pioglitazone on TGFbeta1 expression in ischemia/reperfusion injury myocardium of rats]. ( Li, Y; Li, ZB; Wang, H; Wang, L; Ye, P, 2013) |
| "Pretreatment with pioglitazone significantly lowered the apoptosis rate of the cardiomyocytes with hypoxia/reoxygenation injury to (8." | 1.37 | [Effect of pioglitazone on hypoxia/reoxygenation injury and protein kinase C expression in neonatal rat cardiomyocytes]. ( Luo, LM; Wang, H; Ye, P; Zhang, JY; Zhu, QW, 2011) |
| "Pioglitazone treatment of KK-A(y) mice for 14 days significantly reduced the accumulation of inflammatory cells in ischemic myocardium, and infarct size 3 days after reperfusion compared to vehicle treatment (p<0." | 1.35 | Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates myocardial ischemia-reperfusion injury in mice with metabolic disorders. ( Fuchigami, S; Hayasaki, T; Honda, T; Kaikita, K; Matsukawa, M; Ogawa, H; Sakashita, N; Sugiyama, S; Takeya, M; Tsujita, K, 2008) |
| "Pioglitazone did inhibit the increase in expressions vs I/R (P < 0." | 1.35 | Antiapoptosis and mitochondrial effect of pioglitazone preconditioning in the ischemic/reperfused heart of rat. ( Feng, YB; Lang, MJ; Li, J; Mao, XB; Tian, L, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 12 (52.17) | 29.6817 |
| 2010's | 10 (43.48) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 1 |
| Huang, C | 1 |
| Zhang, D | 1 |
| Zhu, Y | 1 |
| Wang, H | 7 |
| Ye, P | 7 |
| Li, Y | 2 |
| Li, ZB | 2 |
| Wang, L | 1 |
| Shen, L | 2 |
| Ye, Y | 4 |
| Lin, Y | 3 |
| Manickavasagam, S | 1 |
| Perez-Polo, JR | 4 |
| Tieu, BC | 1 |
| Birnbaum, Y | 3 |
| Yasuda, S | 1 |
| Kobayashi, H | 1 |
| Iwasa, M | 1 |
| Kawamura, I | 1 |
| Sumi, S | 1 |
| Narentuoya, B | 1 |
| Yamaki, T | 1 |
| Ushikoshi, H | 1 |
| Nishigaki, K | 1 |
| Nagashima, K | 1 |
| Takemura, G | 1 |
| Fujiwara, T | 1 |
| Fujiwara, H | 1 |
| Minatoguchi, S | 1 |
| Hu, Z | 1 |
| Zhang, C | 1 |
| Keyes, KT | 1 |
| Zhang, CF | 1 |
| Long, B | 1 |
| Qian, J | 1 |
| Ahmed, LA | 1 |
| Salem, HA | 1 |
| Attia, AS | 1 |
| Agha, AM | 1 |
| Kataoka, Y | 1 |
| Yagi, N | 1 |
| Kokubu, N | 1 |
| Kasahara, Y | 1 |
| Abe, M | 1 |
| Otsuka, Y | 1 |
| Zhu, QW | 3 |
| Zhang, JY | 2 |
| Luo, LM | 2 |
| Cao, ZL | 2 |
| Ito, H | 1 |
| Nakano, A | 1 |
| Kinoshita, M | 1 |
| Matsumori, A | 1 |
| Long, CL | 1 |
| Chen, K | 2 |
| Li, XW | 1 |
| Wynne, AM | 1 |
| Mocanu, MM | 1 |
| Yellon, DM | 1 |
| Makino, N | 1 |
| Sugano, M | 1 |
| Satoh, S | 1 |
| Oyama, J | 1 |
| Maeda, T | 1 |
| Taniguchi, Y | 1 |
| Ooie, T | 1 |
| Takahashi, N | 1 |
| Shinohara, T | 1 |
| Nakagawa, M | 1 |
| Yonemochi, H | 1 |
| Hara, M | 1 |
| Yoshimatsu, H | 1 |
| Saikawa, T | 1 |
| Cao, Z | 1 |
| Long, C | 1 |
| Li, X | 1 |
| Sasaki, H | 1 |
| Ogawa, K | 1 |
| Shimizu, M | 1 |
| Mori, C | 1 |
| Takatsuka, H | 1 |
| Okazaki, F | 1 |
| Kawai, M | 1 |
| Taniguchi, I | 1 |
| Mochizuki, S | 1 |
| Honda, T | 1 |
| Kaikita, K | 1 |
| Tsujita, K | 1 |
| Hayasaki, T | 1 |
| Matsukawa, M | 1 |
| Fuchigami, S | 1 |
| Sugiyama, S | 1 |
| Sakashita, N | 1 |
| Ogawa, H | 1 |
| Takeya, M | 1 |
| Li, J | 1 |
| Lang, MJ | 1 |
| Mao, XB | 1 |
| Tian, L | 1 |
| Feng, YB | 1 |
| Wayman, NS | 1 |
| Hattori, Y | 1 |
| McDonald, MC | 1 |
| Mota-Filipe, H | 1 |
| Cuzzocrea, S | 1 |
| Pisano, B | 1 |
| Chatterjee, PK | 1 |
| Thiemermann, C | 1 |
1 trial available for pioglitazone and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Effect of pretreatment with pioglitazone on reperfusion injury in diabetic patients with acute myocardial infarction.
Topics: Aged; Creatine Kinase; Diabetes Complications; Female; Follow-Up Studies; Humans; Hypoglycemic Agent | 2011 |
22 other studies available for pioglitazone and Injury, Myocardial Reperfusion
| Article | Year |
|---|---|
Pioglitazone Protects Against Hypoxia-Induced Cardiomyocyte Apoptosis Through Inhibiting NLRP3/Caspase-1 Pathway in vivo and in vitro.
Topics: Apoptosis; Caspase 1; Creatine Kinase; Cytochromes c; Eosine Yellowish-(YS); Hematoxylin; Humans; Hy | 2022 |
[Effects of pioglitazone on TGFbeta1 expression in ischemia/reperfusion injury myocardium of rats].
Topics: Anilides; Animals; Apoptosis; Male; Myocardial Reperfusion Injury; Myocardium; Pioglitazone; PPAR ga | 2013 |
[Effects of pioglitazone on myocardial peroxisome proliferator-activated receptor gamma co-activator lα expression in rats with myocardial ischemia/reperfusion injury].
Topics: Anilides; Animals; Apoptosis; Male; Myocardial Reperfusion Injury; Myocardium; Peroxisome Proliferat | 2014 |
Pioglitazone protects the myocardium against ischemia-reperfusion injury in eNOS and iNOS knockout mice.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Cardiovascular Agents; Cyclooxygenase 2; Cytochrome P-450 Enz | 2008 |
Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction.
Topics: Androstadienes; Anilides; Animals; Blood Glucose; Blotting, Western; Decanoic Acids; Disease Models, | 2009 |
Downregulation of microRNA-29 by antisense inhibitors and a PPAR-gamma agonist protects against myocardial ischaemia-reperfusion injury.
Topics: Anilides; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Northern; Blotting, Western; Cas | 2010 |
Additive effect of TAK-491, a new angiotensin receptor blocker, and pioglitazone, in reducing myocardial infarct size.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apoptosis; bcl-2-Associated X Protein; Blood Press | 2010 |
Pioglitazone limits myocardial infarct size, activates Akt, and upregulates cPLA2 and COX-2 in a PPAR-γ-independent manner.
Topics: Animals; Cyclooxygenase 2; Enzyme Activation; Gene Expression; Hypoglycemic Agents; Immunoblotting; | 2011 |
Pharmacological preconditioning with nicorandil and pioglitazone attenuates myocardial ischemia/reperfusion injury in rats.
Topics: Animals; Arrhythmias, Cardiac; Heart Rate; Ischemic Preconditioning, Myocardial; Male; Myocardial Is | 2011 |
[Effect of pioglitazone on hypoxia/reoxygenation injury and protein kinase C expression in neonatal rat cardiomyocytes].
Topics: Animals; Animals, Newborn; Apoptosis; Cell Hypoxia; Female; Ischemic Preconditioning, Myocardial; Ma | 2011 |
[Effects of pioglitazone on mitochondrial membrane potential of neonate rat's myocardial cells after hypoxia/reoxygenation].
Topics: Animals; Animals, Newborn; Cell Hypoxia; Cells, Cultured; Female; Male; Membrane Potential, Mitochon | 2011 |
Pioglitazone attenuates myocardial ischemia-reperfusion injury via up-regulation of ERK and COX-2.
Topics: Anilides; Animals; Apoptosis; Blotting, Western; Cyclooxygenase 2; Extracellular Signal-Regulated MA | 2012 |
Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates myocardial ischemia/reperfusion injury in a rat model.
Topics: Animals; Chemokine CCL2; Disease Models, Animal; Hypoglycemic Agents; Intercellular Adhesion Molecul | 2003 |
[The effect of pioglitazone on apoptotic cardiomyocytes for ischemia reperfusion].
Topics: Animals; Apoptosis; Male; Myocardial Reperfusion Injury; Myocardium; Myocytes, Cardiac; Pioglitazone | 2005 |
Pioglitazone mimics preconditioning in the isolated perfused rat heart: a role for the prosurvival kinases PI3K and P42/44MAPK.
Topics: Animals; Dose-Response Relationship, Drug; Hypoglycemic Agents; Ischemic Preconditioning, Myocardial | 2005 |
Peroxisome proliferator-activated receptor-gamma ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia.
Topics: Angiotensin II; Animals; Animals, Newborn; Blotting, Northern; Blotting, Western; Cell Hypoxia; Cell | 2006 |
Pioglitazone but not glibenclamide improves cardiac expression of heat shock protein 72 and tolerance against ischemia/reperfusion injury in the heredity insulin-resistant rat.
Topics: Animals; Blotting, Western; Diabetes Mellitus, Type 2; Fever; Glucose Tolerance Test; Glyburide; HSP | 2006 |
Effect of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on ischemia-reperfusion injury in rats.
Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Caspase 3; DNA Fragmentation; Dose-Response Relation | 2007 |
The insulin sensitizer pioglitazone improves the deterioration of ischemic preconditioning in type 2 diabetes mellitus rats.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Diabetes Mellitus, Type 2; Disease Models, Anim | 2007 |
Pioglitazone, a peroxisome proliferator-activated receptor-gamma agonist, attenuates myocardial ischemia-reperfusion injury in mice with metabolic disorders.
Topics: Animals; Body Weight; Cells, Cultured; Gene Expression Regulation; Heart Ventricles; Inflammation; M | 2008 |
Antiapoptosis and mitochondrial effect of pioglitazone preconditioning in the ischemic/reperfused heart of rat.
Topics: Animals; Animals, Newborn; Apoptosis; bcl-2-Associated X Protein; Cardiovascular Agents; Caspase 3; | 2008 |
Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarct size.
Topics: Adult; Animals; Cardiotonic Agents; Cell Adhesion Molecules; Cell Line; Cells, Cultured; Chemokine C | 2002 |