Page last updated: 2024-11-02

pioglitazone and Infertility, Female

pioglitazone has been researched along with Infertility, Female in 8 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Infertility, Female: Diminished or absent ability of a female to achieve conception.

Research Excerpts

ExcerptRelevanceReference
"Although the number of follicles was higher in the pioglitazone group, our study showed no differences in ovary stimulation and pregnancy rate."9.41Combination of pioglitazone and clomiphene citrate versus clomiphene citrate alone for infertile women with the polycystic ovarian syndrome. ( Amirian, M; Jafarian, F; Mirteimouri, M; Nikdoust, S; Niroumand, S; Payrovnaziri, A; Salehi, M; Shariat Moghani, S, 2021)
"To examine the efficacy of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone among women with polycystic ovary syndrome (PCOS) resistant to clomifene citrate."9.22A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome. ( Abdel Moety, G; Al Mohammady, M; El-khayat, W; Hamed, D, 2016)
"To investigate the efficacy of pioglitazone on fecundity in infertile patients with polycystic ovary syndrome (PCOS) who are resistant to conventional ovulation induction such as clomiphene, dexamethasone, or metformin."9.13Successful pregnancies treated with pioglitazone in infertile patients with polycystic ovary syndrome. ( Goto, T; Ohyama, N; Ota, H; Yoshioka, T, 2008)
" Insulin-sensitising agents such as metformin may be effective in treating PCOS-related anovulation."8.95Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. ( Balen, AH; Morley, LC; Norman, RJ; Tang, T; Yasmin, E, 2017)
"A total of 27 RCTs with 12 interventions were included, and all therapies tended to increase clinical pregnancy, especially pioglitazone (PIO) (log OR 3."5.41The effects of first-line pharmacological treatments for reproductive outcomes in infertile women with PCOS: a systematic review and network meta-analysis. ( Li, J; Liu, Y; Ma, J; Peng, G; Tong, N; Wang, Y; Yan, Z, 2023)
"Although the number of follicles was higher in the pioglitazone group, our study showed no differences in ovary stimulation and pregnancy rate."5.41Combination of pioglitazone and clomiphene citrate versus clomiphene citrate alone for infertile women with the polycystic ovarian syndrome. ( Amirian, M; Jafarian, F; Mirteimouri, M; Nikdoust, S; Niroumand, S; Payrovnaziri, A; Salehi, M; Shariat Moghani, S, 2021)
"To examine the efficacy of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone among women with polycystic ovary syndrome (PCOS) resistant to clomifene citrate."5.22A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome. ( Abdel Moety, G; Al Mohammady, M; El-khayat, W; Hamed, D, 2016)
"To investigate the efficacy of pioglitazone on fecundity in infertile patients with polycystic ovary syndrome (PCOS) who are resistant to conventional ovulation induction such as clomiphene, dexamethasone, or metformin."5.13Successful pregnancies treated with pioglitazone in infertile patients with polycystic ovary syndrome. ( Goto, T; Ohyama, N; Ota, H; Yoshioka, T, 2008)
" Insulin-sensitising agents such as metformin may be effective in treating PCOS-related anovulation."4.95Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. ( Balen, AH; Morley, LC; Norman, RJ; Tang, T; Yasmin, E, 2017)
"The combination of dimethylbiguanide and pioglitazone was more effective for the treatment of PCOS complicated with IR than simple pioglitazone; chronic inflammation occurrence was possibly one of reasons for insulin sensitivity reduction of patients with PCOS."3.80Treatment of polycystic ovarian syndrome with insulin resistance by insulin-sensitizer. ( Hu, L; Hu, MH; Shen, H; Tian, L; Wu, QF, 2014)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (25.00)29.6817
2010's4 (50.00)24.3611
2020's2 (25.00)2.80

Authors

AuthorsStudies
Peng, G1
Yan, Z1
Liu, Y1
Li, J1
Ma, J1
Tong, N1
Wang, Y1
Amirian, M1
Shariat Moghani, S1
Jafarian, F1
Mirteimouri, M1
Nikdoust, S1
Niroumand, S1
Salehi, M1
Payrovnaziri, A1
Ibáñez, L1
Del Río, L1
Díaz, M1
Sebastiani, G1
Pozo, ÓJ1
López-Bermejo, A1
de Zegher, F1
Morley, LC1
Tang, T1
Yasmin, E1
Norman, RJ1
Balen, AH1
Hu, L1
Shen, H1
Wu, QF1
Tian, L1
Hu, MH1
El-khayat, W1
Abdel Moety, G1
Al Mohammady, M1
Hamed, D1
Ota, H1
Goto, T1
Yoshioka, T1
Ohyama, N1

Clinical Trials (7)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Independent and Additive Effects Of Micronutrients With Metformin In Patients With PCOS:A Double Blind Randomized Placebo Controlled Trial[NCT05653895]250 participants (Anticipated)Interventional2022-12-07Recruiting
The Effects of Acetyl L--Carnitine and Myo/Chiro-Inositol on Improving Ovulation, Pregnancy Rate, Ovarian Function and Perceived Stress Response in Patients With PCOS[NCT05767515]120 participants (Anticipated)Interventional2023-04-15Not yet recruiting
Combined Letrozole-metformin-pioglitazone Versus Combined Clomiphene Citrate-metformin-pioglitazone in Clomiphene Citrate-resistant Women With Polycystic Ovary Syndrome[NCT01909141]Early Phase 1100 participants (Actual)Interventional2013-08-31Completed
The Experience of Living With Polycystic Ovary Syndrome in the Military[NCT03876665]24 participants (Actual)Observational2019-08-15Completed
A Multicenter Randomized Trial of Personalized Acupuncture, Fixed Acupuncture, Letrozole and Placebo on Live Birth for Infertility in Women With Polycystic Ovary Syndrome[NCT03625531]Phase 31,100 participants (Anticipated)Interventional2018-08-13Recruiting
Effects of Inositol Alone or Associated With Alpha-lipoic Acid in Polycystic Ovary Syndrome Treatment[NCT04881851]90 participants (Anticipated)Interventional2015-05-07Recruiting
A Multicenter, Prospective, Randomized Study to Assess the Effect of Metformin Supplementation on IVF Outcome and Intrafollicular Environment in Patients With Polycystic Ovarian Syndrome Undergoing In Vitro Fertilization/Embryo Transfer[NCT03086005]Phase 324 participants (Actual)Interventional2011-10-12Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Endometrial Thickness

(NCT01909141)
Timeframe: 3 months

Interventionmm (Mean)
Arm 1:Letrozole-pioglitazone -Metformin Group10.56
Arm 2: Clomiphene Citrate-pioglitazone-metformin9.68

Number of Follicles>18mm.

(NCT01909141)
Timeframe: 3 months

Interventionfollicles (Mean)
Arm 1:Letrozole-pioglitazone -Metformin Group1.44
Arm 2: Clomiphene Citrate-pioglitazone-metformin1.5

Ovulation Rate

(NCT01909141)
Timeframe: 3 months

Interventionpercentage of all cycles (Number)
Arm 1:Letrozole-pioglitazone -Metformin Group93
Arm 2: Clomiphene Citrate-pioglitazone-metformin108

Pregnancy Rate

(NCT01909141)
Timeframe: 3 months

Interventionparticipants (Number)
Arm 1:Letrozole-pioglitazone -Metformin Group28
Arm 2: Clomiphene Citrate-pioglitazone-metformin24

Safety of Pioglitazone as Regards Serum Creatinine

serum creatinine was measured at the end of the study period (after 3 months) in both groups. (NCT01909141)
Timeframe: 3 months

Interventionmg/dL (Mean)
Arm 1:Letrozole-pioglitazone -Metformin Group0.62
Arm 2: Clomiphene Citrate-pioglitazone-metformin0.57

Reviews

2 reviews available for pioglitazone and Infertility, Female

ArticleYear
The effects of first-line pharmacological treatments for reproductive outcomes in infertile women with PCOS: a systematic review and network meta-analysis.
    Reproductive biology and endocrinology : RB&E, 2023, Mar-03, Volume: 21, Issue:1

    Topics: Abortion, Spontaneous; Clomiphene; Female; Humans; Infertility, Female; Live Birth; Metformin; Netwo

2023
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
    The Cochrane database of systematic reviews, 2017, 11-29, Volume: 11

    Topics: Abortion, Spontaneous; Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Fe

2017
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
    The Cochrane database of systematic reviews, 2017, 11-29, Volume: 11

    Topics: Abortion, Spontaneous; Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Fe

2017
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
    The Cochrane database of systematic reviews, 2017, 11-29, Volume: 11

    Topics: Abortion, Spontaneous; Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Fe

2017
Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility.
    The Cochrane database of systematic reviews, 2017, 11-29, Volume: 11

    Topics: Abortion, Spontaneous; Anovulation; Clomiphene; Female; Humans; Hypoglycemic Agents; Infertility, Fe

2017

Trials

4 trials available for pioglitazone and Infertility, Female

ArticleYear
Combination of pioglitazone and clomiphene citrate versus clomiphene citrate alone for infertile women with the polycystic ovarian syndrome.
    BMC women's health, 2021, 08-17, Volume: 21, Issue:1

    Topics: Clomiphene; Female; Fertility Agents, Female; Humans; Infertility, Female; Ovulation Induction; Piog

2021
Normalizing Ovulation Rate by Preferential Reduction of Hepato-Visceral Fat in Adolescent Girls With Polycystic Ovary Syndrome.
    The Journal of adolescent health : official publication of the Society for Adolescent Medicine, 2017, Volume: 61, Issue:4

    Topics: Adolescent; Body Mass Index; Contraceptives, Oral, Combined; Drug Combinations; Ethinyl Estradiol; F

2017
A randomized controlled trial of clomifene citrate, metformin, and pioglitazone versus letrozole, metformin, and pioglitazone for clomifene-citrate-resistant polycystic ovary syndrome.
    International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics, 2016, Volume: 132, Issue:2

    Topics: Adult; Clomiphene; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Egypt; Female; F

2016
Successful pregnancies treated with pioglitazone in infertile patients with polycystic ovary syndrome.
    Fertility and sterility, 2008, Volume: 90, Issue:3

    Topics: Adult; Female; Fertility Agents, Female; Humans; Hypoglycemic Agents; Infertility, Female; Pioglitaz

2008

Other Studies

2 other studies available for pioglitazone and Infertility, Female

ArticleYear
Treatment of polycystic ovarian syndrome with insulin resistance by insulin-sensitizer.
    Clinical and experimental obstetrics & gynecology, 2014, Volume: 41, Issue:3

    Topics: Adolescent; Adult; Blood Glucose; Body Mass Index; C-Reactive Protein; Cholesterol, HDL; Cholesterol

2014
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008
Consensus on infertility treatment related to polycystic ovary syndrome.
    Human reproduction (Oxford, England), 2008, Volume: 23, Issue:3

    Topics: Clomiphene; Diet, Reducing; Exercise; Female; Fertilization in Vitro; Gonadotropin-Releasing Hormone

2008