pioglitazone has been researched along with Hypoxia in 6 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In the present study, it was examined whether treatment with PPAR‑γ agonist pioglitazone (PIO) is beneficial in counteracting SEV‑induced neuroinflammation and cognitive decline in a rat model of CIH." | 7.91 | Pioglitazone prevents sevoflurane‑induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR‑γ. ( Dong, P; Fei, J; Li, D; Li, L; Li, N; Lin, Q; Lu, L; Yang, B; Zhang, X, 2019) |
| " In the present study, it was examined whether treatment with PPAR‑γ agonist pioglitazone (PIO) is beneficial in counteracting SEV‑induced neuroinflammation and cognitive decline in a rat model of CIH." | 3.91 | Pioglitazone prevents sevoflurane‑induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR‑γ. ( Dong, P; Fei, J; Li, D; Li, L; Li, N; Lin, Q; Lu, L; Yang, B; Zhang, X, 2019) |
| "Cardiac fibroblasts were exposed to anoxia (95% N2/5% CO2) and then reoxygenation (95% air/5% CO2)." | 1.32 | Anoxia-reoxygenation stimulates collagen type-I and MMP-1 expression in cardiac fibroblasts: modulation by the PPAR-gamma ligand pioglitazone. ( Chen, K; Hermonat, PL; Li, D; Mehta, JL; Zhang, X, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 2 (33.33) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, H | 2 |
| Huang, C | 1 |
| Zhang, D | 1 |
| Zhu, Y | 1 |
| Liu, Y | 1 |
| Luo, Q | 1 |
| Su, Z | 1 |
| Xing, J | 1 |
| Wu, J | 1 |
| Xiang, L | 1 |
| Huang, Y | 1 |
| Pan, H | 1 |
| Wu, X | 1 |
| Zhang, X | 3 |
| Li, J | 1 |
| Yan, F | 1 |
| Li, N | 1 |
| Lu, L | 1 |
| Lin, Q | 1 |
| Li, L | 1 |
| Dong, P | 1 |
| Yang, B | 1 |
| Li, D | 2 |
| Fei, J | 1 |
| Corsini, I | 1 |
| Polvani, S | 1 |
| Tarocchi, M | 1 |
| Tempesti, S | 1 |
| Marroncini, G | 1 |
| Generoso, M | 1 |
| Bresci, C | 1 |
| Gozzini, E | 1 |
| Bianconi, T | 1 |
| Galli, A | 1 |
| Dani, C | 1 |
| Chen, K | 1 |
| Hermonat, PL | 1 |
| Mehta, JL | 1 |
| Li, X | 1 |
| Kimura, H | 1 |
| Hirota, K | 1 |
| Sugimoto, H | 1 |
| Kimura, N | 1 |
| Takahashi, N | 1 |
| Fujii, H | 1 |
| Yoshida, H | 1 |
6 other studies available for pioglitazone and Hypoxia
| Article | Year |
|---|---|
Pioglitazone Protects Against Hypoxia-Induced Cardiomyocyte Apoptosis Through Inhibiting NLRP3/Caspase-1 Pathway in vivo and in vitro.
Topics: Apoptosis; Caspase 1; Creatine Kinase; Cytochromes c; Eosine Yellowish-(YS); Hematoxylin; Humans; Hy | 2022 |
Suppression of Myocardial Hypoxia-Inducible Factor-1α Compromises Metabolic Adaptation and Impairs Cardiac Function in Patients With Cyanotic Congenital Heart Disease During Puberty.
Topics: Animals; Disease Models, Animal; Fatty Acids; Glucose; Glycolysis; Heart Defects, Congenital; Humans | 2021 |
Pioglitazone prevents sevoflurane‑induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR‑γ.
Topics: Animals; Chronic Disease; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Hypoglycemic A | 2019 |
Peroxisome proliferator-activated receptor-γ agonist pioglitazone reduces the development of necrotizing enterocolitis in a neonatal preterm rat model.
Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Enterocoliti | 2017 |
Anoxia-reoxygenation stimulates collagen type-I and MMP-1 expression in cardiac fibroblasts: modulation by the PPAR-gamma ligand pioglitazone.
Topics: Animals; Blotting, Western; Collagen Type I; Electrophoretic Mobility Shift Assay; Fibroblasts; Hypo | 2004 |
Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-gamma in human proximal renal tubular cells.
Topics: Antioxidants; Cells, Cultured; Chemokine CCL2; Cyclic N-Oxides; Gene Expression Regulation; Humans; | 2007 |