Page last updated: 2024-11-02

pioglitazone and Hypoxia

pioglitazone has been researched along with Hypoxia in 6 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Hypoxia: Sub-optimal OXYGEN levels in the ambient air of living organisms.

Research Excerpts

ExcerptRelevanceReference
" In the present study, it was examined whether treatment with PPAR‑γ agonist pioglitazone (PIO) is beneficial in counteracting SEV‑induced neuroinflammation and cognitive decline in a rat model of CIH."7.91Pioglitazone prevents sevoflurane‑induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR‑γ. ( Dong, P; Fei, J; Li, D; Li, L; Li, N; Lin, Q; Lu, L; Yang, B; Zhang, X, 2019)
" In the present study, it was examined whether treatment with PPAR‑γ agonist pioglitazone (PIO) is beneficial in counteracting SEV‑induced neuroinflammation and cognitive decline in a rat model of CIH."3.91Pioglitazone prevents sevoflurane‑induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR‑γ. ( Dong, P; Fei, J; Li, D; Li, L; Li, N; Lin, Q; Lu, L; Yang, B; Zhang, X, 2019)
"Cardiac fibroblasts were exposed to anoxia (95% N2/5% CO2) and then reoxygenation (95% air/5% CO2)."1.32Anoxia-reoxygenation stimulates collagen type-I and MMP-1 expression in cardiac fibroblasts: modulation by the PPAR-gamma ligand pioglitazone. ( Chen, K; Hermonat, PL; Li, D; Mehta, JL; Zhang, X, 2004)

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (33.33)29.6817
2010's2 (33.33)24.3611
2020's2 (33.33)2.80

Authors

AuthorsStudies
Zhang, H2
Huang, C1
Zhang, D1
Zhu, Y1
Liu, Y1
Luo, Q1
Su, Z1
Xing, J1
Wu, J1
Xiang, L1
Huang, Y1
Pan, H1
Wu, X1
Zhang, X3
Li, J1
Yan, F1
Li, N1
Lu, L1
Lin, Q1
Li, L1
Dong, P1
Yang, B1
Li, D2
Fei, J1
Corsini, I1
Polvani, S1
Tarocchi, M1
Tempesti, S1
Marroncini, G1
Generoso, M1
Bresci, C1
Gozzini, E1
Bianconi, T1
Galli, A1
Dani, C1
Chen, K1
Hermonat, PL1
Mehta, JL1
Li, X1
Kimura, H1
Hirota, K1
Sugimoto, H1
Kimura, N1
Takahashi, N1
Fujii, H1
Yoshida, H1

Other Studies

6 other studies available for pioglitazone and Hypoxia

ArticleYear
Pioglitazone Protects Against Hypoxia-Induced Cardiomyocyte Apoptosis Through Inhibiting NLRP3/Caspase-1 Pathway in vivo and in vitro.
    International heart journal, 2022, Sep-30, Volume: 63, Issue:5

    Topics: Apoptosis; Caspase 1; Creatine Kinase; Cytochromes c; Eosine Yellowish-(YS); Hematoxylin; Humans; Hy

2022
Suppression of Myocardial Hypoxia-Inducible Factor-1α Compromises Metabolic Adaptation and Impairs Cardiac Function in Patients With Cyanotic Congenital Heart Disease During Puberty.
    Circulation, 2021, 06-08, Volume: 143, Issue:23

    Topics: Animals; Disease Models, Animal; Fatty Acids; Glucose; Glycolysis; Heart Defects, Congenital; Humans

2021
Pioglitazone prevents sevoflurane‑induced neuroinflammation and cognitive decline in a rat model of chronic intermittent hypoxia by upregulating hippocampal PPAR‑γ.
    Molecular medicine reports, 2019, Volume: 19, Issue:5

    Topics: Animals; Chronic Disease; Cognitive Dysfunction; Disease Models, Animal; Hippocampus; Hypoglycemic A

2019
Peroxisome proliferator-activated receptor-γ agonist pioglitazone reduces the development of necrotizing enterocolitis in a neonatal preterm rat model.
    Pediatric research, 2017, Volume: 81, Issue:2

    Topics: Animals; Animals, Newborn; Anti-Inflammatory Agents; Cytokines; Disease Models, Animal; Enterocoliti

2017
Anoxia-reoxygenation stimulates collagen type-I and MMP-1 expression in cardiac fibroblasts: modulation by the PPAR-gamma ligand pioglitazone.
    Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:6

    Topics: Animals; Blotting, Western; Collagen Type I; Electrophoretic Mobility Shift Assay; Fibroblasts; Hypo

2004
Hypoxia reduces the expression and anti-inflammatory effects of peroxisome proliferator-activated receptor-gamma in human proximal renal tubular cells.
    Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2007, Volume: 22, Issue:4

    Topics: Antioxidants; Cells, Cultured; Chemokine CCL2; Cyclic N-Oxides; Gene Expression Regulation; Humans;

2007