Page last updated: 2024-11-02

pioglitazone and Hyperlipemia

pioglitazone has been researched along with Hyperlipemia in 44 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Research Excerpts

ExcerptRelevanceReference
"To evaluate the effects of pioglitazone on insulin sensitivity and levels of biomarkers associated with thrombotic risk in overweight and obese, non-diabetic subjects with coronary artery disease."9.12Effects of pioglitazone on fasting and postprandial levels of lipid and hemostatic variables in overweight non-diabetic patients with coronary artery disease. ( Dodis, R; Francis, CW; Gerich, JE; Kaba, NK; Lee, M; Messing, S; Mieszczanska, H; Phipps, RP; Schwarz, KQ; Smith, BH; Taubman, MB, 2007)
"Combination of pioglitazone and losartan is more effective in reducing renal injury-induced atherosclerosis than either treatment alone."7.81Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype. ( Fazio, S; Kon, V; Linton, MF; Narita, I; Yamamoto, S; Yancey, PG; Yang, H; Zhong, J; Zuo, Y, 2015)
"To investigate the relationship between insulin resistance, postprandial hyperglycemia, postprandial hyperlipidemia, and oxidative stress in type 2 diabetes, changes in postprandial glucose, triglyceride, and nitrotyrosine levels vs baseline after diet loading were examined in type 2 diabetic patients given pioglitazone (PG) or glibenclamide (GB)."5.12Effects of pioglitazone vs glibenclamide on postprandial increases in glucose and triglyceride levels and on oxidative stress in Japanese patients with type 2 diabetes. ( Itoh, Y; Mori, Y; Obata, T; Tajima, N, 2006)
"To evaluate the effects of pioglitazone on insulin sensitivity and levels of biomarkers associated with thrombotic risk in overweight and obese, non-diabetic subjects with coronary artery disease."5.12Effects of pioglitazone on fasting and postprandial levels of lipid and hemostatic variables in overweight non-diabetic patients with coronary artery disease. ( Dodis, R; Francis, CW; Gerich, JE; Kaba, NK; Lee, M; Messing, S; Mieszczanska, H; Phipps, RP; Schwarz, KQ; Smith, BH; Taubman, MB, 2007)
"Pioglitazone improved insulin resistance and glycemic control, as well as Tg and HDL-C - which suggests that pioglitazone may reduce cardiovascular risk for patients with type 2 diabetes."5.09The impact of pioglitazone on glycemic control and atherogenic dyslipidemia in patients with type 2 diabetes mellitus. ( Glazer, NB; Miskin, B; Prince, MJ; Robertson, KE; Rosenblatt, S, 2001)
" Search terms used were insulin resistance, diabetes, insulin sensitivity, obesity, cardiovascular disease, metformin, thiazolidinediones, pioglitazone, rosiglitazone, and troglitazone."4.82Insulin resistance: from predisposing factor to therapeutic target in type 2 diabetes. ( Henry, RR, 2003)
"Combination of pioglitazone and losartan is more effective in reducing renal injury-induced atherosclerosis than either treatment alone."3.81Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype. ( Fazio, S; Kon, V; Linton, MF; Narita, I; Yamamoto, S; Yancey, PG; Yang, H; Zhong, J; Zuo, Y, 2015)
" A range of parameters was evaluated including body weight development, plasma levels of total cholesterol, triglycerides (TG), low-density-lipoprotein cholesterol, high-density lipoprotein cholesterol (HDL-C), adiponectin, leptin, glucose, insulin, interleukin-6 (IL-6), atherogenic index (AI) and the coronary risk index (CRI)."3.80Ficus carica leaf extract modulates the lipid profile of rats fed with a high-fat diet through an increase of HDL-C. ( Benedek, B; Bonnländer, B; Butterweck, V; Joerin, L; Kauschka, M; Pischel, I, 2014)
"We examined oxidative stress and metabolic characteristics of the spontaneously hypertensive hyperlipidemic rat (SHHR) when it was fed a high-fat diet and sucrose solution (HFDS) after N(G)-nitro-L-arginine methyl ester ingestion to develop a rat model of metabolic syndrome."3.74Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution. ( Iwai, S; Kobayashi, S; Kumai, T; Oguchi, K; Okazaki, M; Saiki, R, 2007)
"Postprandial hyperlipidaemia in type 2 diabetes is secondary to increased chylomicron production by the enterocytes and delayed catabolism of chylomicrons and chylomicron remnants."2.82Intestinal lipid absorption and transport in type 2 diabetes. ( Vergès, B, 2022)
"Pioglitazone treatment resulted in a significant increase in total (5."2.73Pioglitazone added to conventional lipid-lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat content. ( Amber, V; Bell, JD; Betteridge, DJ; Fitzpatrick, J; Hamilton, G; Holvoet, P; Hughes, R; Naoumova, RP; North, C; Potter, E; Seed, M; Thomas, EL; Tosi, I, 2007)
"Treatment with pioglitazone 30 or 45 mg QD for 16 weeks reduced mean HbA(1c) by 0."2.71A randomized, double-blind, placebo-controlled, clinical trial of the effects of pioglitazone on glycemic control and dyslipidemia in oral antihyperglycemic medication-naive patients with type 2 diabetes mellitus. ( Duran, S; Escobar-Jiménez, F; Godin, C; Grossman, LD; Hardin, PA; Hawkins, F; Herz, M; Johns, D; Konkoy, CS; Lochnan, H; Reviriego, J; Tan, MH, 2003)
"Overall, 7% of the US population has type 2 diabetes mellitus (T2DM), and among people aged 60 years or older, approximately 20% have T2DM, representing a significant health burden in this age group."2.44Initiating insulin in patients with type 2 diabetes. ( Aoki, TJ; White, RD, 2007)
"Type 2 diabetes is characterised by a gradual decline in glycaemic control and progression from oral glucose-lowering monotherapy to combination therapy and exogenous insulin therapy."2.44Pioglitazone and sulfonylureas: effectively treating type 2 diabetes. ( Hanefeld, M, 2007)
"Patients with type 2 diabetes mellitus frequently have coexistent dyslipidemia, hypertension, and obesity, and are at risk for microvascular and macrovascular disease complications such as myocardial infarction, stroke, retinopathy, and microalbuminuria."2.42Type 2 diabetes, cardiovascular risk, and the link to insulin resistance. ( Chilton, RJ; Stolar, MW, 2003)
"Valvular inflammation triggered by hyperlipidemia has been considered as an important initial process of aortic valve disease; however, cellular and molecular evidence remains unclear."1.72Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia. ( Ahn, HS; Ann, SJ; Choi, JH; Chung, J; Go, DM; Han, I; Jeong, SC; Kim, DY; Kim, K; Kim, KW; Kim, M; Kim, N; Kim, TK; Lee, HO; Lee, S; Lee, SH; Lee, SP; Oh, GT; Park, J; Park, JH; Park, KS; Park, SE; Park, WY; Shim, D; Woo, SH; Yoon, WK; Zhang, JY, 2022)
"Atorvastatin monotherapy was effective at reducing cholesterol (from 4."1.62Therapeutic effects of an aspalathin-rich green rooibos extract, pioglitazone and atorvastatin combination therapy in diabetic db/db mice. ( Awortwe, C; Joubert, E; Louw, J; Muller, CJF; Patel, O; Rosenkranz, B, 2021)
"Treatment with pioglitazone improved serum lipid profile of non-diabetic hyperlipidaemic rats equivalent to that of gemfibrozil."1.43Pioglitazone improves serum lipid profile in diet induced hyperlipidaemic non diabetic rats. ( Arain, AQ; Chiragh, S; Hussian, M, 2016)
"Treatment with pioglitazone decreased the neointimal content of lipid in 20-week-old mice from 50 +/- 6% to 30 +/- 7%, p=0."1.33Attenuation of accumulation of neointimal lipid by pioglitazone in mice genetically deficient in insulin receptor substrate-2 and apolipoprotein E. ( Clough, MH; Schneider, DJ; Sobel, BE; Taatjes, DJ; Wadsworth, MP; White, MF, 2005)
"In the present study, we assessed hyperlipidemia in Apc-deficient mice, model animals for human familial adenomatous polyposis, and examined the effects of pioglitazone and bezafibrate, respectively, PPARgamma and PPARalpha agonists, on both hyperlipidemia and intestinal polyposis."1.32Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. ( Itoh, M; Kitamura, T; Niho, N; Noda, T; Shoji, Y; Sugimura, T; Takahashi, M; Wakabayashi, K, 2003)

Research

Studies (44)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (2.27)18.2507
2000's32 (72.73)29.6817
2010's7 (15.91)24.3611
2020's4 (9.09)2.80

Authors

AuthorsStudies
Willson, TM1
Brown, PJ1
Sternbach, DD1
Henke, BR1
Vergès, B2
Lee, SH3
Kim, N1
Kim, M1
Woo, SH1
Han, I1
Park, J1
Kim, K2
Park, KS1
Shim, D1
Park, SE1
Zhang, JY1
Go, DM1
Kim, DY1
Yoon, WK1
Lee, SP1
Chung, J1
Kim, KW1
Park, JH1
Lee, S1
Ann, SJ1
Ahn, HS1
Jeong, SC1
Kim, TK1
Oh, GT1
Park, WY1
Lee, HO1
Choi, JH1
Patel, O1
Muller, CJF1
Joubert, E1
Rosenkranz, B1
Louw, J1
Awortwe, C1
Lee, M2
Ovbiagele, B1
Saver, JL1
Xia, JY1
Sun, K1
Hepler, C1
Ghaben, AL1
Gupta, RK1
An, YA1
Holland, WL1
Morley, TS1
Adams, AC1
Gordillo, R1
Kusminski, CM1
Scherer, PE1
Joerin, L1
Kauschka, M1
Bonnländer, B1
Pischel, I1
Benedek, B1
Butterweck, V1
Sakata, S1
Mera, Y1
Kuroki, Y1
Nashida, R1
Kakutani, M1
Ohta, T1
Yamamoto, S1
Zhong, J1
Yancey, PG1
Zuo, Y1
Linton, MF1
Fazio, S1
Yang, H1
Narita, I1
Kon, V1
Leonard, CE1
Han, X1
Bilker, WB1
Flory, JH1
Brensinger, CM1
Flockhart, DA1
Gagne, JJ1
Cardillo, S1
Hennessy, S1
Polyzos, SA1
Bugianesi, E1
Kountouras, J1
Mantzoros, CS1
Hussian, M1
Arain, AQ1
Chiragh, S1
Aoki, TJ1
White, RD1
Kotake, H1
Tan, MH3
Herz, M1
Johns, D1
Reviriego, J1
Grossman, LD1
Godin, C1
Duran, S1
Hawkins, F1
Lochnan, H1
Escobar-Jiménez, F1
Hardin, PA1
Konkoy, CS1
Niho, N4
Takahashi, M3
Kitamura, T1
Shoji, Y2
Itoh, M1
Noda, T1
Sugimura, T3
Wakabayashi, K4
Stolar, MW1
Chilton, RJ1
Henry, RR1
Takeuchi, Y2
Matsubara, S1
Yokote, K1
Honjo, S1
Kobayashi, K1
Fujimoto, M1
Kawamura, H1
Mori, S1
Saito, Y1
Khan, M1
Xu, Y1
Edwards, G1
Urquhart, R1
Mariz, S1
Clough, MH1
Schneider, DJ1
Sobel, BE1
White, MF1
Wadsworth, MP1
Taatjes, DJ1
Mukhtar, R1
Reckless, JP1
Goldberg, RB1
Kendall, DM1
Deeg, MA1
Buse, JB1
Zagar, AJ1
Pinaire, JA1
Khan, MA1
Perez, AT1
Jacober, SJ1
Mutoh, M2
Mori, Y1
Itoh, Y1
Obata, T1
Tajima, N1
Trivedi, NR1
Cong, Z1
Nelson, AM1
Albert, AJ1
Rosamilia, LL1
Sivarajah, S1
Gilliland, KL1
Liu, W1
Mauger, DT1
Gabbay, RA1
Thiboutot, DM1
Senba, H1
Kawano, M1
Kawakami, M1
Sakano, K1
Yamamoto, M1
Sato, H1
Mieszczanska, H1
Kaba, NK1
Francis, CW1
Gerich, JE1
Dodis, R1
Schwarz, KQ1
Phipps, RP1
Smith, BH1
Messing, S1
Taubman, MB1
Thomas, EL1
Potter, E1
Tosi, I1
Fitzpatrick, J1
Hamilton, G1
Amber, V1
Hughes, R1
North, C1
Holvoet, P1
Seed, M1
Betteridge, DJ1
Bell, JD1
Naoumova, RP1
Hanefeld, M1
Saiki, R1
Okazaki, M1
Iwai, S1
Kumai, T1
Kobayashi, S1
Oguchi, K1
Tanabe, J1
Tamasawa, N1
Yamashita, M1
Matsuki, K1
Murakami, H1
Matsui, J1
Sugimoto, K1
Yasujima, M1
Suda, T1
Wild, RA1
Nakagawa, T1
Goto, H1
Hussein, G1
Hikiami, H1
Shibahara, N1
Shimada, Y1
Kadowaki, T1
de Souza, CJ1
Eckhardt, M1
Gagen, K1
Dong, M1
Chen, W1
Laurent, D1
Burkey, BF1
Rosenblatt, S1
Miskin, B1
Glazer, NB1
Prince, MJ1
Robertson, KE1
Nakamura, T1
Ushiyama, C1
Osada, S1
Shimada, N1
Ebihara, I1
Koide, H1
Ikeda, H1
Taketomi, S1
Sugiyama, Y1
Shimura, Y1
Sohda, T1
Meguro, K1
Fujita, T1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pioglitazone Versus Rosiglitazone in Subjects With Type 2 Diabetes Mellitus and Dyslipidemia[NCT00331487]Phase 3719 participants (Actual)Interventional2000-09-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

13 reviews available for pioglitazone and Hyperlipemia

ArticleYear
The PPARs: from orphan receptors to drug discovery.
    Journal of medicinal chemistry, 2000, Feb-24, Volume: 43, Issue:4

    Topics: Animals; Diabetes Mellitus; Drug Design; Humans; Hyperlipidemias; Hypertension; Inflammation; Ligand

2000
Intestinal lipid absorption and transport in type 2 diabetes.
    Diabetologia, 2022, Volume: 65, Issue:10

    Topics: Apolipoprotein B-48; Cholesterol; Chylomicron Remnants; Chylomicrons; Diabetes Mellitus, Type 2; Dip

2022
Initiating insulin in patients with type 2 diabetes.
    The Journal of family practice, 2007, Volume: 56, Issue:8 Suppl Ho

    Topics: Blood Glucose; Cholesterol; Comorbidity; Diabetes Mellitus, Type 2; Drug Monitoring; Drug Therapy, C

2007
[Syndrome X].
    Nihon rinsho. Japanese journal of clinical medicine, 2002, Volume: 60 Suppl 10

    Topics: Animals; Bezafibrate; Biguanides; Fatty Acids, Nonesterified; Humans; Hyperglycemia; Hyperinsulinism

2002
[Thiazolidinediones: effect of the pioglitazone on hyperglycemia, dyslipidemia and cardiovascular risk].
    Revista clinica espanola, 2003, Volume: 203, Issue:1

    Topics: Cardiovascular Diseases; Humans; Hyperglycemia; Hyperlipidemias; Hypoglycemic Agents; Pioglitazone;

2003
Type 2 diabetes, cardiovascular risk, and the link to insulin resistance.
    Clinical therapeutics, 2003, Volume: 25 Suppl B

    Topics: Cardiovascular Diseases; Diabetes Complications; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hemod

2003
Insulin resistance: from predisposing factor to therapeutic target in type 2 diabetes.
    Clinical therapeutics, 2003, Volume: 25 Suppl B

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Humans; Hyperlipidemias; Hypoglycemic Agents; Insulin Resi

2003
Metabolic improvement and abdominal fat redistribution in Werner syndrome by pioglitazone.
    Journal of the American Geriatrics Society, 2004, Volume: 52, Issue:9

    Topics: Abdomen; Adipose Tissue; Body Constitution; Female; Glucose; Glucose Tolerance Test; Humans; Hyperli

2004
Dyslipidaemia in type 2 diabetes: effects of the thiazolidinediones pioglitazone and rosiglitazone.
    Diabetic medicine : a journal of the British Diabetic Association, 2005, Volume: 22 Suppl 3

    Topics: Diabetes Mellitus, Type 2; Evidence-Based Medicine; Humans; Hyperlipidemias; Hypoglycemic Agents; Me

2005
Concomitant suppression of hyperlipidemia and intestinal polyp formation by increasing lipoprotein lipase activity in Apc-deficient mice.
    Biological chemistry, 2006, Volume: 387, Issue:4

    Topics: Age Factors; Animals; Benzamides; Bezafibrate; Cyclooxygenase 2; Genes, APC; Humans; Hyperlipidemias

2006
Pioglitazone and sulfonylureas: effectively treating type 2 diabetes.
    International journal of clinical practice. Supplement, 2007, Issue:153

    Topics: Cardiovascular Diseases; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hyperlipidemi

2007
Effects of glitazones in the treatment of diabetes and/or hyperlipidaemia: glycaemic control and plasma lipid levels.
    Fundamental & clinical pharmacology, 2007, Volume: 21 Suppl 2

    Topics: Blood Glucose; Diabetes Mellitus, Type 2; Glycated Hemoglobin; Humans; Hyperlipidemias; Hypoglycemic

2007
[Hypoglycemic agents to improve insulin resistance].
    Nihon rinsho. Japanese journal of clinical medicine, 2000, Volume: 58, Issue:2

    Topics: Adipocytes; Animals; Cell Differentiation; Chromans; Diabetes Mellitus, Type 2; Disease Models, Anim

2000

Trials

9 trials available for pioglitazone and Hyperlipemia

ArticleYear
A randomized, double-blind, placebo-controlled, clinical trial of the effects of pioglitazone on glycemic control and dyslipidemia in oral antihyperglycemic medication-naive patients with type 2 diabetes mellitus.
    Clinical therapeutics, 2003, Volume: 25, Issue:4

    Topics: Adult; Aged; Aged, 80 and over; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship

2003
Effects of pioglitazone on the components of diabetic dyslipidaemia: results of double-blind, multicentre, randomised studies.
    International journal of clinical practice, 2004, Volume: 58, Issue:10

    Topics: Adult; Aged; Cardiovascular Diseases; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mellitus, Type 2;

2004
A comparison of lipid and glycemic effects of pioglitazone and rosiglitazone in patients with type 2 diabetes and dyslipidemia.
    Diabetes care, 2005, Volume: 28, Issue:7

    Topics: Aged; Apolipoproteins B; Blood Glucose; C-Peptide; Cholesterol, HDL; Cholesterol, LDL; Diabetes Mell

2005
Effects of pioglitazone vs glibenclamide on postprandial increases in glucose and triglyceride levels and on oxidative stress in Japanese patients with type 2 diabetes.
    Endocrine, 2006, Volume: 29, Issue:1

    Topics: Aged; Blood Glucose; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Fatty Acids, Nones

2006
Peroxisome proliferator-activated receptors increase human sebum production.
    The Journal of investigative dermatology, 2006, Volume: 126, Issue:9

    Topics: Adult; Cell Line, Transformed; Diabetes Mellitus; Female; Fenofibrate; Gemfibrozil; Humans; Hyperlip

2006
Effects of pioglitazone on fasting and postprandial levels of lipid and hemostatic variables in overweight non-diabetic patients with coronary artery disease.
    Journal of thrombosis and haemostasis : JTH, 2007, Volume: 5, Issue:5

    Topics: Adult; Aged; Coronary Artery Disease; Cross-Over Studies; Double-Blind Method; Fasting; Female; Hemo

2007
Pioglitazone added to conventional lipid-lowering treatment in familial combined hyperlipidaemia improves parameters of metabolic control: relation to liver, muscle and regional body fat content.
    Atherosclerosis, 2007, Volume: 195, Issue:1

    Topics: Adipose Tissue; Adult; Double-Blind Method; Humans; Hyperlipidemias; Hypoglycemic Agents; Lipids; Li

2007
The impact of pioglitazone on glycemic control and atherogenic dyslipidemia in patients with type 2 diabetes mellitus.
    Coronary artery disease, 2001, Volume: 12, Issue:5

    Topics: Adult; Aged; Arteriosclerosis; Blood Glucose; C-Peptide; Diabetes Mellitus, Type 2; Double-Blind Met

2001
Effect of pioglitazone on dyslipidemia in hemodialysis patients with type 2 diabetes.
    Renal failure, 2001, Volume: 23, Issue:6

    Topics: Cholesterol, HDL; Diabetes Mellitus, Type 2; Female; Glyburide; Glycated Hemoglobin; Humans; Hyperli

2001

Other Studies

22 other studies available for pioglitazone and Hyperlipemia

ArticleYear
Single-cell transcriptomics reveal cellular diversity of aortic valve and the immunomodulation by PPARγ during hyperlipidemia.
    Nature communications, 2022, 09-17, Volume: 13, Issue:1

    Topics: Animals; Aortic Valve; Aortic Valve Stenosis; Calcinosis; Cells, Cultured; Endothelial Cells; Humans

2022
Therapeutic effects of an aspalathin-rich green rooibos extract, pioglitazone and atorvastatin combination therapy in diabetic db/db mice.
    PloS one, 2021, Volume: 16, Issue:5

    Topics: Animals; Aspalathus; Atorvastatin; Blood Glucose; Chalcones; Diabetes Mellitus, Experimental; Diabet

2021
Intensive Medical Management to Prevent Large and Small Artery Atherothrombotic Stroke: Time to Expand the Horizon.
    JAMA, 2021, Jul-20, Volume: 326, Issue:3

    Topics: Eicosapentaenoic Acid; Folic Acid; Glucagon-Like Peptide-1 Receptor; Humans; Hyperlipidemias; Hypogl

2021
Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice.
    Diabetologia, 2018, Volume: 61, Issue:4

    Topics: Adipocytes; Adiponectin; Adipose Tissue; Animals; Blood Glucose; Gene Deletion; Gene Expression Prof

2018
Ficus carica leaf extract modulates the lipid profile of rats fed with a high-fat diet through an increase of HDL-C.
    Phytotherapy research : PTR, 2014, Volume: 28, Issue:2

    Topics: Adiponectin; Animals; Blood Glucose; Body Weight; Cholesterol, HDL; Cholesterol, LDL; Diet, High-Fat

2014
Combination therapy of an intestine-specific inhibitor of microsomal triglyceride transfer protein and peroxisome proliferator-activated receptor γ agonist in diabetic rat.
    Journal of diabetes research, 2014, Volume: 2014

    Topics: Adipose Tissue, White; Animals; Benzamides; Carrier Proteins; Diabetes Mellitus, Type 2; Drug Therap

2014
Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype.
    Atherosclerosis, 2015, Volume: 242, Issue:1

    Topics: Angiotensin Receptor Antagonists; Animals; Aortic Diseases; Apolipoproteins E; Apoptosis; Atheroscle

2015
Comparative risk of severe hypoglycemia among concomitant users of thiazolidinedione antidiabetic agents and antihyperlipidemics.
    Diabetes research and clinical practice, 2016, Volume: 115

    Topics: Aged; Diabetes Mellitus; Drug Interactions; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhi

2016
Nonalcoholic fatty liver disease: Updates on associations with the metabolic syndrome and lipid profile and effects of treatment with PPAR-γ agonists.
    Metabolism: clinical and experimental, 2017, Volume: 66

    Topics: Animals; Biomedical Research; Humans; Hyperlipidemias; Hypoglycemic Agents; Ligands; Lipotropic Agen

2017
Pioglitazone improves serum lipid profile in diet induced hyperlipidaemic non diabetic rats.
    JPMA. The Journal of the Pakistan Medical Association, 2016, Volume: 66, Issue:10

    Topics: Animals; Diet; Hyperlipidemias; Hypoglycemic Agents; Lipids; Pakistan; Pioglitazone; Rats; Rats, Spr

2016
Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands.
    Cancer research, 2003, Sep-15, Volume: 63, Issue:18

    Topics: Age Factors; Animals; Bezafibrate; Cholesterol; Fatty Acids, Nonesterified; Genes, APC; Hyperlipidem

2003
Dose-dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPAR gamma ligand.
    Cancer science, 2003, Volume: 94, Issue:11

    Topics: Animals; Cholesterol, LDL; Colonic Polyps; Dose-Response Relationship, Drug; Genes, APC; Hyperlipide

2003
Insulin sensitizer affects lipids.
    Health news (Waltham, Mass.), 2005, Volume: 11, Issue:1

    Topics: Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hyperlipidemias; Hypoglycemic Agents;

2005
Attenuation of accumulation of neointimal lipid by pioglitazone in mice genetically deficient in insulin receptor substrate-2 and apolipoprotein E.
    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 2005, Volume: 53, Issue:5

    Topics: Administration, Oral; Animals; Aorta; Apolipoproteins E; Arteriosclerosis; Hyperlipidemias; Hypoglyc

2005
Severe decrease in serum HDL-cholesterol during combination therapy of bezafibrate and pioglitazone.
    Journal of atherosclerosis and thrombosis, 2006, Volume: 13, Issue:5

    Topics: Bezafibrate; Cholesterol, HDL; Diabetes Mellitus, Type 2; Drug Therapy, Combination; Humans; Hyperli

2006
Suppression of N-nitrosobis(2-oxopropyl)amine-induced pancreatic carcinogenesis in hamsters by pioglitazone, a ligand of peroxisome proliferator-activated receptor gamma.
    Carcinogenesis, 2007, Volume: 28, Issue:8

    Topics: Animals; Antineoplastic Agents; Carcinogens; Cricetinae; Female; Hyperlipidemias; Ligands; Lipoprote

2007
Effects of pioglitazone on increases in visceral fat accumulation and oxidative stress in spontaneously hypertensive hyperlipidemic rats fed a high-fat diet and sucrose solution.
    Journal of pharmacological sciences, 2007, Volume: 105, Issue:2

    Topics: Animals; Catalase; Dietary Fats; Disease Models, Animal; Fatty Acids, Nonesterified; Female; Glutath

2007
Effects of combined PPARgamma and PPARalpha agonist therapy on reverse cholesterol transport in the Zucker diabetic fatty rat.
    Diabetes, obesity & metabolism, 2008, Volume: 10, Issue:9

    Topics: Animals; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Blood Glucose; Chole

2008
Pioglitazone and metformin for increased small low-density lipoprotein in polycystic ovary syndrome: counterpoint.
    American journal of obstetrics and gynecology, 2008, Volume: 198, Issue:1

    Topics: Adult; Atherosclerosis; Cholesterol, LDL; Female; Follow-Up Studies; Humans; Hyperlipidemias; Metfor

2008
Keishibukuryogan ameliorates glucose intolerance and hyperlipidemia in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
    Diabetes research and clinical practice, 2008, Volume: 80, Issue:1

    Topics: Adiponectin; Animals; Blood Glucose; Body Weight; Diabetes Mellitus, Type 2; Drugs, Chinese Herbal;

2008
Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance.
    Diabetes, 2001, Volume: 50, Issue:8

    Topics: Adipocytes; Adipose Tissue; Analysis of Variance; Animals; Blood Glucose; Cell Division; Cell Size;

2001
Effects of pioglitazone on glucose and lipid metabolism in normal and insulin resistant animals.
    Arzneimittel-Forschung, 1990, Volume: 40, Issue:2 Pt 1

    Topics: Adipose Tissue; Animals; Diabetes Mellitus, Experimental; Dogs; Glucose; Glucose Tolerance Test; Hyp

1990