pioglitazone has been researched along with Heart Valve Diseases in 1 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Heart Valve Diseases: Pathological conditions involving any of the various HEART VALVES and the associated structures (PAPILLARY MUSCLES and CHORDAE TENDINEAE).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Treatment with pioglitazone prevented abnormal valve calcification, but did not protect valve function." | 1.42 | Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice. ( Baumbach, GL; Brooks, RM; Chen, B; Chu, Y; Davis, MK; Doshi, H; El Accaoui, RN; Funk, ND; Hajj, GP; Hameed, T; Heistad, DD; Leinwand, LA; Lund, DD; Magida, JA; Song, LS; Weiss, RM; Zimmerman, KA, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hajj, GP | 1 |
| Chu, Y | 1 |
| Lund, DD | 1 |
| Magida, JA | 1 |
| Funk, ND | 1 |
| Brooks, RM | 1 |
| Baumbach, GL | 1 |
| Zimmerman, KA | 1 |
| Davis, MK | 1 |
| El Accaoui, RN | 1 |
| Hameed, T | 1 |
| Doshi, H | 1 |
| Chen, B | 1 |
| Leinwand, LA | 1 |
| Song, LS | 1 |
| Heistad, DD | 1 |
| Weiss, RM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effect of Pioglitazone Treatment in Patient's Calcific Aortic Valve Disease With Mild Aortic Valve Stenosis[NCT05875675] | Phase 2 | 100 participants (Anticipated) | Interventional | 2023-07-01 | Not yet recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 other study available for pioglitazone and Heart Valve Diseases
| Article | Year |
|---|---|
Spontaneous Aortic Regurgitation and Valvular Cardiomyopathy in Mice.
Topics: Actins; Animals; Aortic Valve; Aortic Valve Insufficiency; Calcinosis; Cell Death; Disease Progressi | 2015 |