pioglitazone has been researched along with Glial Cell Tumors in 10 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Gliomas are the most common primary tumors of the central nervous system." | 5.37 | Peroxisome proliferator-activated receptor γ agonist pioglitazone inhibits β-catenin-mediated glioma cell growth and invasion. ( Chen, J; Lan, Q; Ma, Y; Shao, B; Shen, A; Shi, J; Shi, W; Wan, Z, 2011) |
| "A phase II trial was initiated to analyze the activity of continuously administered pioglitazone and rofecoxib combined with low-dose chemotherapy (capecitabine or temozolomide) in patients with high-grade gliomas (glioblastoma or anaplastic glioma)." | 5.12 | Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study. ( Baumgart, U; Bogdahn, U; Hau, P; Hirschmann, B; Kunz-Schughart, L; Muhleisen, H; Reichle, A; Ruemmele, P; Steinbrecher, A; Weimann, E, 2007) |
| "These data indicate that pioglitazone crosses the blood-brain barrier and has antineoplastic effects in this glioma xenograft model and may be of potential use in treatment of malignant gliomas." | 3.79 | The PPARγ agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model. ( Blankenship, D; Caprariello, A; Dechant, A; Grommes, C; Karlo, JC; Landreth, GE, 2013) |
| "In this study the authors explored the benefits of treating C57B1/6 mice with an established intracerebral glioma by combining immunotherapy with interleukin (IL)-2-secreting syngeneic/allogeneic fibroblasts administered into the tumor bed along with the chemotherapeutic agent pioglitazone, a thiazolidinedione (TZD)." | 3.74 | Prolonged survival of mice with established intracerebral glioma receiving combined treatment with peroxisome proliferator-activated receptor-gamma thiazolidinedione agonists and interleukin-2-secreting syngeneic/allogeneic fibroblasts. ( Cohen, EP; Feinstein, DL; Glick, RP; Lichtor, T; Lin, H; Spagnolo, A, 2007) |
| "Gliomas are the most common primary tumors of the central nervous system." | 1.37 | Peroxisome proliferator-activated receptor γ agonist pioglitazone inhibits β-catenin-mediated glioma cell growth and invasion. ( Chen, J; Lan, Q; Ma, Y; Shao, B; Shen, A; Shi, J; Shi, W; Wan, Z, 2011) |
| "Glioblastoma represent the most common primary brain tumor in adults and are currently considered incurable." | 1.35 | PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models. ( Heneka, MT; Hermes, M; Kummer, MP; Orlandi, M; Papi, A; Tatenhorst, L; Terwel, D, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 6 (60.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Khoo, NK | 1 |
| Hebbar, S | 1 |
| Zhao, W | 1 |
| Moore, SA | 1 |
| Domann, FE | 1 |
| Robbins, ME | 1 |
| Ren, H | 1 |
| Gao, Z | 1 |
| Wu, N | 1 |
| Zeng, L | 1 |
| Tang, X | 1 |
| Chen, X | 1 |
| Liu, Z | 1 |
| Zhang, W | 1 |
| Wang, L | 1 |
| Li, Z | 1 |
| Tapia-Pérez, JH | 1 |
| Preininger, R | 1 |
| Kirches, E | 1 |
| Reinhold, A | 1 |
| Butzmann, J | 1 |
| Prilloff, S | 1 |
| Mawrin, C | 1 |
| Schneider, T | 1 |
| Papi, A | 1 |
| Tatenhorst, L | 1 |
| Terwel, D | 1 |
| Hermes, M | 1 |
| Kummer, MP | 1 |
| Orlandi, M | 1 |
| Heneka, MT | 2 |
| Grommes, C | 3 |
| Conway, DS | 1 |
| Alshekhlee, A | 1 |
| Barnholtz-Sloan, JS | 1 |
| Wan, Z | 1 |
| Shi, W | 1 |
| Shao, B | 1 |
| Shi, J | 1 |
| Shen, A | 1 |
| Ma, Y | 1 |
| Chen, J | 1 |
| Lan, Q | 1 |
| Karlo, JC | 1 |
| Caprariello, A | 1 |
| Blankenship, D | 1 |
| Dechant, A | 1 |
| Landreth, GE | 2 |
| Sastre, M | 1 |
| Beck, M | 1 |
| Feinstein, DL | 2 |
| Jacobs, AH | 1 |
| Schlegel, U | 1 |
| Spagnolo, A | 1 |
| Glick, RP | 1 |
| Lin, H | 1 |
| Cohen, EP | 1 |
| Lichtor, T | 1 |
| Hau, P | 1 |
| Kunz-Schughart, L | 1 |
| Bogdahn, U | 1 |
| Baumgart, U | 1 |
| Hirschmann, B | 1 |
| Weimann, E | 1 |
| Muhleisen, H | 1 |
| Ruemmele, P | 1 |
| Steinbrecher, A | 1 |
| Reichle, A | 1 |
1 trial available for pioglitazone and Glial Cell Tumors
| Article | Year |
|---|---|
Low-dose chemotherapy in combination with COX-2 inhibitors and PPAR-gamma agonists in recurrent high-grade gliomas - a phase II study.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Brain Neoplasms; Capecitabin | 2007 |
9 other studies available for pioglitazone and Glial Cell Tumors
| Article | Year |
|---|---|
Differential activation of catalase expression and activity by PPAR agonists: implications for astrocyte protection in anti-glioma therapy.
Topics: Animals; Astrocytes; Catalase; Chlorocebus aethiops; COS Cells; Gene Expression Regulation; Glioma; | 2013 |
Expression of REST4 in human gliomas in vivo and influence of pioglitazone on REST in vitro.
Topics: Alternative Splicing; Brain Neoplasms; Cell Line, Tumor; Gene Expression Regulation, Neoplastic; Gli | 2015 |
Simultaneous Administration of Statins and Pioglitazone Limits Tumor Growth in a Rat Model of Malignant Glioma.
Topics: Animals; Brain Neoplasms; Disease Models, Animal; Glioma; Hydroxymethylglutaryl-CoA Reductase Inhibi | 2016 |
PPARgamma and RXRgamma ligands act synergistically as potent antineoplastic agents in vitro and in vivo glioma models.
Topics: Analysis of Variance; Animals; Annexin A5; Antineoplastic Agents; bcl-2-Associated X Protein; Brain | 2009 |
Inverse association of PPARγ agonists use and high grade glioma development.
Topics: Aged; Antineoplastic Agents; Brain Neoplasms; Female; Glioma; Humans; Kaplan-Meier Estimate; Male; P | 2010 |
Peroxisome proliferator-activated receptor γ agonist pioglitazone inhibits β-catenin-mediated glioma cell growth and invasion.
Topics: Antineoplastic Agents; Apoptosis; beta Catenin; Cell Line, Tumor; Cell Migration Assays; Cell Moveme | 2011 |
The PPARγ agonist pioglitazone crosses the blood-brain barrier and reduces tumor growth in a human xenograft model.
Topics: Animals; Blood-Brain Barrier; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Glioma; Humans; | 2013 |
Inhibition of in vivo glioma growth and invasion by peroxisome proliferator-activated receptor gamma agonist treatment.
Topics: Administration, Oral; Animals; Apoptosis; bcl-2-Associated X Protein; Brain Neoplasms; Bromodeoxyuri | 2006 |
Prolonged survival of mice with established intracerebral glioma receiving combined treatment with peroxisome proliferator-activated receptor-gamma thiazolidinedione agonists and interleukin-2-secreting syngeneic/allogeneic fibroblasts.
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Cell Culture Techniques; Cell Line, Tumor; Cell Sur | 2007 |