pioglitazone has been researched along with Gastric Ulcer in 8 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chronic treatment with pioglitazone exerts a more prominent gastroprotective effect on the stomach ulcers of cirrhotic rats compared to control group probably due to constitutive nitric oxide synthase induction or inducible nitric oxide synthase inhibition." | 7.79 | Enhanced anti-ulcer effect of pioglitazone on gastric ulcers in cirrhotic rats: the role of nitric oxide and IL-1β. ( Amirghofran, Z; Dehpour, AR; Heidari, R; Moezi, L; Monabati, A; Nekooeian, AA, 2013) |
| " We determined the effect of the specific PPAR-gamma ligand, pioglitazone (5-40 mg/kg intragastrically), on the healing of acetic-acid gastric ulcers in rats." | 7.72 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat. ( Brzozowski, T; Hahn, EG; Kania, J; Konturek, PC; Konturek, SJ; Kwiecien, S; Pajdo, R, 2003) |
| "Pioglitazone treatment reduced the severity of ulceration, repressed levels of TNF-alpha, IL-1beta and nuclear p65 subunit as well as increased the abundance of PPAR-gamma in gastric mucosa." | 5.35 | Involvement of glucocorticoid receptor and peroxisome proliferator activated receptor-gamma in pioglitazone mediated chronic gastric ulcer healing in rats. ( Lahiri, S; Palit, G; Sen, T, 2009) |
| "Chronic treatment with pioglitazone exerts a more prominent gastroprotective effect on the stomach ulcers of cirrhotic rats compared to control group probably due to constitutive nitric oxide synthase induction or inducible nitric oxide synthase inhibition." | 3.79 | Enhanced anti-ulcer effect of pioglitazone on gastric ulcers in cirrhotic rats: the role of nitric oxide and IL-1β. ( Amirghofran, Z; Dehpour, AR; Heidari, R; Moezi, L; Monabati, A; Nekooeian, AA, 2013) |
| " Six weeks following streptozotocin or saline injection, gastric ulcers were induced by serosal application of acetic acid." | 3.77 | Role of activation of 5'-adenosine monophosphate-activated protein kinase in gastric ulcer healing in diabetic rats. ( Baraka, AM; Deif, MM, 2011) |
| " We determined the effect of the specific PPAR-gamma ligand, pioglitazone (5-40 mg/kg intragastrically), on the healing of acetic-acid gastric ulcers in rats." | 3.72 | Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat. ( Brzozowski, T; Hahn, EG; Kania, J; Konturek, PC; Konturek, SJ; Kwiecien, S; Pajdo, R, 2003) |
| "Pretreatment with pioglitazone dose-dependently attenuated gastric lesions induced by ethanol in both sham and cholestatic rats, but this effect was more prominent in cholestatic ones." | 1.40 | The increased gastroprotective effect of pioglitazone in cholestatic rats: role of nitric oxide and tumour necrosis factor alpha. ( Amirghofran, Z; Dehpour, AR; Janahmadi, Z; Moezi, L; Nekooeian, AA, 2014) |
| "Pioglitazone treatment reduced the severity of ulceration, repressed levels of TNF-alpha, IL-1beta and nuclear p65 subunit as well as increased the abundance of PPAR-gamma in gastric mucosa." | 1.35 | Involvement of glucocorticoid receptor and peroxisome proliferator activated receptor-gamma in pioglitazone mediated chronic gastric ulcer healing in rats. ( Lahiri, S; Palit, G; Sen, T, 2009) |
| "Pre-treatment with pioglitazone dose-dependently attenuated gastric lesions induced by 100% ethanol and WRS; the dose reducing these lesions by 50% (ID50) being 10 mg/kg and 7 mg/kg, respectively." | 1.33 | Agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma): a new compound with potent gastroprotective and ulcer healing properties. ( Brzozowski, T; Burnat, G; Cieszkowski, J; Hahn, EG; Konturek, PC; Konturek, S; Kwiecień, SN; Pajdo, R; Pawlik, WW; Targosz, A, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 4 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Moezi, L | 2 |
| Heidari, R | 1 |
| Amirghofran, Z | 2 |
| Nekooeian, AA | 2 |
| Monabati, A | 1 |
| Dehpour, AR | 2 |
| Janahmadi, Z | 1 |
| Lahiri, S | 1 |
| Sen, T | 1 |
| Palit, G | 1 |
| Konturek, PC | 4 |
| Brzozowski, T | 4 |
| Burnat, G | 2 |
| Szlachcic, A | 1 |
| Koziel, J | 1 |
| Kwiecien, S | 3 |
| Konturek, SJ | 3 |
| Harsch, IA | 1 |
| Baraka, AM | 1 |
| Deif, MM | 1 |
| Kania, J | 2 |
| Kukharsky, V | 1 |
| Bazela, K | 1 |
| Harsch, I | 1 |
| Hahn, EG | 3 |
| Pajdo, R | 2 |
| Kwiecień, SN | 1 |
| Konturek, S | 1 |
| Targosz, A | 1 |
| Cieszkowski, J | 1 |
| Pawlik, WW | 1 |
8 other studies available for pioglitazone and Gastric Ulcer
| Article | Year |
|---|---|
Enhanced anti-ulcer effect of pioglitazone on gastric ulcers in cirrhotic rats: the role of nitric oxide and IL-1β.
Topics: Animals; Anti-Ulcer Agents; Disease Models, Animal; Dose-Response Relationship, Drug; Interleukin-1b | 2013 |
The increased gastroprotective effect of pioglitazone in cholestatic rats: role of nitric oxide and tumour necrosis factor alpha.
Topics: Animals; Cholestasis; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Interleukin | 2014 |
Involvement of glucocorticoid receptor and peroxisome proliferator activated receptor-gamma in pioglitazone mediated chronic gastric ulcer healing in rats.
Topics: Animals; Anti-Ulcer Agents; Chronic Disease; Dose-Response Relationship, Drug; Female; Gastric Mucos | 2009 |
Gastric ulcer healing and stress-lesion preventive properties of pioglitazone are attenuated in diabetic rats.
Topics: Animals; Diabetes Mellitus, Experimental; Male; Pioglitazone; Protective Agents; Rats; Rats, Wistar; | 2010 |
Role of activation of 5'-adenosine monophosphate-activated protein kinase in gastric ulcer healing in diabetic rats.
Topics: Acetic Acid; Animals; Blood Glucose; Cyclic AMP-Dependent Protein Kinases; Diabetes Mellitus, Experi | 2011 |
Pioglitazone, a specific ligand of the peroxisome proliferator-activated receptor gamma reduces gastric mucosal injury induced by ischaemia/ reperfusion in rat.
Topics: Amino Acid Sequence; Animals; Cyclooxygenase 1; Cyclooxygenase 2; Gastric Mucosa; Hypoglycemic Agent | 2003 |
Pioglitazone, a specific ligand of peroxisome proliferator-activated receptor-gamma, accelerates gastric ulcer healing in rat.
Topics: Animals; Ligands; Male; Pioglitazone; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Rece | 2003 |
Agonist of peroxisome proliferator-activated receptor gamma (PPAR-gamma): a new compound with potent gastroprotective and ulcer healing properties.
Topics: Animals; Anti-Ulcer Agents; Blood Flow Velocity; Blotting, Western; Dinoprostone; Dose-Response Rela | 2005 |