pioglitazone has been researched along with Depressive Disorder in 1 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Rasgon, N | 1 |
Lin, KW | 1 |
Lin, J | 1 |
Epel, E | 1 |
Blackburn, E | 1 |
Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
---|---|---|---|---|---|---|---|
Pioglitazone Treatment for Insulin Resistant Patients With Mood Disorders[NCT01559857] | Phase 4 | 37 participants (Actual) | Interventional | 2011-11-30 | Completed | ||
[information is prepared from clinicaltrials.gov, extracted Sep-2024] |
The HDRS-21 was administered at baseline and at the end of 12 weeks, and the mean difference between the two time points was calculated. The HDRS-21 is scored on a scale from 0 to 21, where 0 is the lowest level of depression severity and 21 is the highest level of depression severity. (NCT01559857)
Timeframe: 12 weeks
Intervention | units on a scale (Mean) |
---|---|
Pio - IS | -4.45 |
Placebo - IS | -3.57 |
Pio - IR | -1.71 |
Placebo - IR | -3.57 |
The fasting plasma insulin measurements taken at baseline are shown in the data table below. (NCT01559857)
Timeframe: Baseline
Intervention | uIU/mL (Mean) |
---|---|
Pio - IS | 10.61 |
Placebo - IS | 9.18 |
Pio - IR | 13.98 |
Placebo - IR | 14.12 |
The HDRS-21 was used to screen for unremitted depression. The HDRS-21 is scored on a scale from 0 to 21, where 0 is the lowest level of depression severity and 21 is the highest level of depression severity. Unremitted depression is characterized by a score of ≥7. The HDRS-21 scores at baseline are shown in the data table below. (NCT01559857)
Timeframe: Baseline
Intervention | units on a scale (Mean) |
---|---|
Pio - IS | 15.22 |
Placebo - IS | 13.67 |
Pio - IR | 19.22 |
Placebo - IR | 13.25 |
1 trial available for pioglitazone and Depressive Disorder
Article | Year |
---|---|
Telomere length as a predictor of response to Pioglitazone in patients with unremitted depression: a preliminary study.
Topics: Adult; Aged; Depressive Disorder; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Insulin | 2016 |