Page last updated: 2024-11-02

pioglitazone and Depressive Disorder

pioglitazone has been researched along with Depressive Disorder in 1 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.

Research

Studies (1)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Rasgon, N1
Lin, KW1
Lin, J1
Epel, E1
Blackburn, E1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Pioglitazone Treatment for Insulin Resistant Patients With Mood Disorders[NCT01559857]Phase 437 participants (Actual)Interventional2011-11-30Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Trial Outcomes

Change in HDRS-21: From Baseline to 12 Weeks

The HDRS-21 was administered at baseline and at the end of 12 weeks, and the mean difference between the two time points was calculated. The HDRS-21 is scored on a scale from 0 to 21, where 0 is the lowest level of depression severity and 21 is the highest level of depression severity. (NCT01559857)
Timeframe: 12 weeks

Interventionunits on a scale (Mean)
Pio - IS-4.45
Placebo - IS-3.57
Pio - IR-1.71
Placebo - IR-3.57

Fasting Insulin Measurements at Baseline

The fasting plasma insulin measurements taken at baseline are shown in the data table below. (NCT01559857)
Timeframe: Baseline

InterventionuIU/mL (Mean)
Pio - IS10.61
Placebo - IS9.18
Pio - IR13.98
Placebo - IR14.12

Hamilton Depression Rating Scale at Baseline

The HDRS-21 was used to screen for unremitted depression. The HDRS-21 is scored on a scale from 0 to 21, where 0 is the lowest level of depression severity and 21 is the highest level of depression severity. Unremitted depression is characterized by a score of ≥7. The HDRS-21 scores at baseline are shown in the data table below. (NCT01559857)
Timeframe: Baseline

Interventionunits on a scale (Mean)
Pio - IS15.22
Placebo - IS13.67
Pio - IR19.22
Placebo - IR13.25

Trials

1 trial available for pioglitazone and Depressive Disorder

ArticleYear
Telomere length as a predictor of response to Pioglitazone in patients with unremitted depression: a preliminary study.
    Translational psychiatry, 2016, Jan-05, Volume: 6

    Topics: Adult; Aged; Depressive Disorder; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Insulin

2016