Page last updated: 2024-11-02

pioglitazone and Condition, Preneoplastic

pioglitazone has been researched along with Condition, Preneoplastic in 7 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Research Excerpts

ExcerptRelevanceReference
"Head and neck cancer is a major source of morbidity and mortality worldwide."2.50PPARγ in head and neck cancer prevention. ( Burotto, M; Szabo, E, 2014)
"Although a correlation between pancreatic cancer and diabetes mellitus has long been suspected, the potential role diabetes mellitus plays in the pathogenicity of both hepatocellular carcinoma and colon cancer is becoming increasingly well defined."2.50Diabetes mellitus as a novel risk factor for gastrointestinal malignancies. ( Herrigel, DJ; Moss, RA, 2014)
"Oral leukoplakia is defined as a mucous membrane disorder characterized by white patches that cannot be scraped off."1.48PPARγ-Mediated p21 Induction in Aerodigestive Preneoplastic Cell Lines. ( Miller, WA; Ondrey, FG; Wuertz, BR, 2018)
"Using a mouse model of lung squamous cell carcinoma (SCC), we performed transcriptome sequencing (RNA-Seq) to profile bronchial airway gene expression and found activation of the PI3K and Myc signaling networks in cytologically normal bronchial airway epithelial cells of mice with preneopastic lung SCC lesions, which was reversed by treatment with the PI3K Inhibitor XL-147 and pioglitazone, respectively."1.46Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents. ( Lubet, RA; Miller, MS; Pan, J; Szabo, E; Wang, Y; Xiong, D; You, M; Zhang, Q, 2017)
"Pioglitazone was chosen as agonist of PPAR-gamma and GW9662 used as a specific complete antagonist of PPAR-gamma."1.35[Role of peroxisome proliferators-activated receptor-gamma in the chemical prevention therapy of sulindac for precancerous lesions of rats]. ( Han, YJ; Jin, Z; Li, CF; Li, J; Lv, YM; Zhang, YP, 2009)

Research

Studies (7)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (14.29)29.6817
2010's6 (85.71)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Miller, WA1
Wuertz, BR1
Ondrey, FG1
Burotto, M1
Szabo, E2
Liclican, EL1
Walser, TC1
Hazra, S1
Krysan, K1
Park, SJ1
Pagano, PC1
Gardner, BK1
Larsen, JE1
Minna, JD1
Dubinett, SM1
Herrigel, DJ1
Moss, RA1
Xiong, D1
Pan, J1
Zhang, Q1
Miller, MS1
Lubet, RA1
You, M1
Wang, Y1
Zhang, YP1
Lv, YM1
Li, J1
Han, YJ1
Jin, Z1
Li, CF1
Li, MY1
Yuan, H1
Ma, LT1
Kong, AW1
Hsin, MK1
Yip, JH1
Underwood, MJ1
Chen, GG1

Reviews

2 reviews available for pioglitazone and Condition, Preneoplastic

ArticleYear
PPARγ in head and neck cancer prevention.
    Oral oncology, 2014, Volume: 50, Issue:10

    Topics: Clinical Trials as Topic; Disease Progression; Evidence-Based Medicine; Head and Neck Neoplasms; Hum

2014
Diabetes mellitus as a novel risk factor for gastrointestinal malignancies.
    Postgraduate medicine, 2014, Volume: 126, Issue:6

    Topics: Adenocarcinoma; Carcinoma, Hepatocellular; Colorectal Neoplasms; Diabetes Complications; Humans; Hyp

2014

Other Studies

5 other studies available for pioglitazone and Condition, Preneoplastic

ArticleYear
PPARγ-Mediated p21 Induction in Aerodigestive Preneoplastic Cell Lines.
    The Annals of otology, rhinology, and laryngology, 2018, Volume: 127, Issue:10

    Topics: Apoptosis; Blotting, Western; Cell Division; Cell Line, Tumor; Cell Proliferation; Gene Expression R

2018
Loss of miR125a expression in a model of K-ras-dependent pulmonary premalignancy.
    Cancer prevention research (Philadelphia, Pa.), 2014, Volume: 7, Issue:8

    Topics: Bronchi; Cell Line; Cell Proliferation; Chemokine CXCL1; Enzyme-Linked Immunosorbent Assay; Epitheli

2014
Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents.
    Oncotarget, 2017, Mar-21, Volume: 8, Issue:12

    Topics: Animals; Biomarkers, Tumor; Bronchi; Carcinoma, Squamous Cell; Chemokines, CXC; Chemoprevention; Dis

2017
[Role of peroxisome proliferators-activated receptor-gamma in the chemical prevention therapy of sulindac for precancerous lesions of rats].
    Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences, 2009, Apr-18, Volume: 41, Issue:2

    Topics: 1,2-Dimethylhydrazine; Anilides; Animals; Colorectal Neoplasms; Male; Pioglitazone; PPAR gamma; Prec

2009
Roles of peroxisome proliferator-activated receptor-alpha and -gamma in the development of non-small cell lung cancer.
    American journal of respiratory cell and molecular biology, 2010, Volume: 43, Issue:6

    Topics: Animals; Carcinoma, Non-Small-Cell Lung; Disease Progression; Female; Gene Expression Regulation, Ne

2010