pioglitazone has been researched along with Condition, Preneoplastic in 7 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Head and neck cancer is a major source of morbidity and mortality worldwide." | 2.50 | PPARγ in head and neck cancer prevention. ( Burotto, M; Szabo, E, 2014) |
| "Although a correlation between pancreatic cancer and diabetes mellitus has long been suspected, the potential role diabetes mellitus plays in the pathogenicity of both hepatocellular carcinoma and colon cancer is becoming increasingly well defined." | 2.50 | Diabetes mellitus as a novel risk factor for gastrointestinal malignancies. ( Herrigel, DJ; Moss, RA, 2014) |
| "Oral leukoplakia is defined as a mucous membrane disorder characterized by white patches that cannot be scraped off." | 1.48 | PPARγ-Mediated p21 Induction in Aerodigestive Preneoplastic Cell Lines. ( Miller, WA; Ondrey, FG; Wuertz, BR, 2018) |
| "Using a mouse model of lung squamous cell carcinoma (SCC), we performed transcriptome sequencing (RNA-Seq) to profile bronchial airway gene expression and found activation of the PI3K and Myc signaling networks in cytologically normal bronchial airway epithelial cells of mice with preneopastic lung SCC lesions, which was reversed by treatment with the PI3K Inhibitor XL-147 and pioglitazone, respectively." | 1.46 | Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents. ( Lubet, RA; Miller, MS; Pan, J; Szabo, E; Wang, Y; Xiong, D; You, M; Zhang, Q, 2017) |
| "Pioglitazone was chosen as agonist of PPAR-gamma and GW9662 used as a specific complete antagonist of PPAR-gamma." | 1.35 | [Role of peroxisome proliferators-activated receptor-gamma in the chemical prevention therapy of sulindac for precancerous lesions of rats]. ( Han, YJ; Jin, Z; Li, CF; Li, J; Lv, YM; Zhang, YP, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (14.29) | 29.6817 |
| 2010's | 6 (85.71) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Miller, WA | 1 |
| Wuertz, BR | 1 |
| Ondrey, FG | 1 |
| Burotto, M | 1 |
| Szabo, E | 2 |
| Liclican, EL | 1 |
| Walser, TC | 1 |
| Hazra, S | 1 |
| Krysan, K | 1 |
| Park, SJ | 1 |
| Pagano, PC | 1 |
| Gardner, BK | 1 |
| Larsen, JE | 1 |
| Minna, JD | 1 |
| Dubinett, SM | 1 |
| Herrigel, DJ | 1 |
| Moss, RA | 1 |
| Xiong, D | 1 |
| Pan, J | 1 |
| Zhang, Q | 1 |
| Miller, MS | 1 |
| Lubet, RA | 1 |
| You, M | 1 |
| Wang, Y | 1 |
| Zhang, YP | 1 |
| Lv, YM | 1 |
| Li, J | 1 |
| Han, YJ | 1 |
| Jin, Z | 1 |
| Li, CF | 1 |
| Li, MY | 1 |
| Yuan, H | 1 |
| Ma, LT | 1 |
| Kong, AW | 1 |
| Hsin, MK | 1 |
| Yip, JH | 1 |
| Underwood, MJ | 1 |
| Chen, GG | 1 |
2 reviews available for pioglitazone and Condition, Preneoplastic
| Article | Year |
|---|---|
PPARγ in head and neck cancer prevention.
Topics: Clinical Trials as Topic; Disease Progression; Evidence-Based Medicine; Head and Neck Neoplasms; Hum | 2014 |
Diabetes mellitus as a novel risk factor for gastrointestinal malignancies.
Topics: Adenocarcinoma; Carcinoma, Hepatocellular; Colorectal Neoplasms; Diabetes Complications; Humans; Hyp | 2014 |
5 other studies available for pioglitazone and Condition, Preneoplastic
| Article | Year |
|---|---|
PPARγ-Mediated p21 Induction in Aerodigestive Preneoplastic Cell Lines.
Topics: Apoptosis; Blotting, Western; Cell Division; Cell Line, Tumor; Cell Proliferation; Gene Expression R | 2018 |
Loss of miR125a expression in a model of K-ras-dependent pulmonary premalignancy.
Topics: Bronchi; Cell Line; Cell Proliferation; Chemokine CXCL1; Enzyme-Linked Immunosorbent Assay; Epitheli | 2014 |
Bronchial airway gene expression signatures in mouse lung squamous cell carcinoma and their modulation by cancer chemopreventive agents.
Topics: Animals; Biomarkers, Tumor; Bronchi; Carcinoma, Squamous Cell; Chemokines, CXC; Chemoprevention; Dis | 2017 |
[Role of peroxisome proliferators-activated receptor-gamma in the chemical prevention therapy of sulindac for precancerous lesions of rats].
Topics: 1,2-Dimethylhydrazine; Anilides; Animals; Colorectal Neoplasms; Male; Pioglitazone; PPAR gamma; Prec | 2009 |
Roles of peroxisome proliferator-activated receptor-alpha and -gamma in the development of non-small cell lung cancer.
Topics: Animals; Carcinoma, Non-Small-Cell Lung; Disease Progression; Female; Gene Expression Regulation, Ne | 2010 |