pioglitazone has been researched along with Colitis in 6 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Colitis: Inflammation of the COLON section of the large intestine (INTESTINE, LARGE), usually with symptoms such as DIARRHEA (often with blood and mucus), ABDOMINAL PAIN, and FEVER.
| Excerpt | Relevance | Reference |
|---|---|---|
| " We investigated the effect of pioglitazone, a peroxisome proliferator-activated receptor-gamma ligand, on dextran sulfate sodium-induced colonic mucosal injury and inflammation in mice." | 7.71 | Pioglitazone, a PPAR-gamma ligand, provides protection from dextran sulfate sodium-induced colitis in mice in association with inhibition of the NF-kappaB-cytokine cascade. ( Handa, O; Ichikawa, H; Naito, Y; Takagi, T; Tomatsuri, N; Yoshida, N; Yoshikawa, T, 2002) |
| " Moreover, macrophage PPAR-γ was required for accelerating pioglitazone-mediated recovery from dextran sodium sulfate (DSS) colitis, providing a cellular target for the anti-inflammatory effects of PPAR-γ agonists in IBD." | 3.77 | Immunoregulatory mechanisms of macrophage PPAR-γ in mice with experimental inflammatory bowel disease. ( Bassaganya-Riera, J; Climent, M; Evans, C; Guri, AJ; Hontecillas, R; Horne, WT; Sobral, BW; Zhang, Y, 2011) |
| " We investigated the effect of pioglitazone, a peroxisome proliferator-activated receptor-gamma ligand, on dextran sulfate sodium-induced colonic mucosal injury and inflammation in mice." | 3.71 | Pioglitazone, a PPAR-gamma ligand, provides protection from dextran sulfate sodium-induced colitis in mice in association with inhibition of the NF-kappaB-cytokine cascade. ( Handa, O; Ichikawa, H; Naito, Y; Takagi, T; Tomatsuri, N; Yoshida, N; Yoshikawa, T, 2002) |
| "Pioglitazone treatment ameliorated the level of decrease in adiponectin expression and improved colonic inflammation induced by the omega-3 fat-rich diet." | 1.35 | Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts. ( Hokari, R; Itoh, K; Kawaguchi, A; Komoto, S; Kurihara, C; Matsunaga, H; Miura, S; Nagao, S; Nakamura, M; Okada, Y; Okudaira, K; Takebayashi, K; Tsuzuki, Y; Watanabe, C, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (50.00) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 1 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Huang, Y | 1 |
| Wang, C | 1 |
| Tian, X | 1 |
| Mao, Y | 1 |
| Hou, B | 1 |
| Sun, Y | 1 |
| Gu, X | 1 |
| Ma, Z | 1 |
| Hontecillas, R | 1 |
| Horne, WT | 1 |
| Climent, M | 1 |
| Guri, AJ | 1 |
| Evans, C | 1 |
| Zhang, Y | 1 |
| Sobral, BW | 1 |
| Bassaganya-Riera, J | 1 |
| Flores, MBS | 1 |
| Rocha, GZ | 1 |
| Damas-Souza, DM | 1 |
| Osório-Costa, F | 1 |
| Dias, MM | 1 |
| Ropelle, ER | 1 |
| Camargo, JA | 1 |
| de Carvalho, RB | 1 |
| Carvalho, HF | 1 |
| Saad, MJA | 1 |
| Carvalheira, JBC | 1 |
| Saubermann, LJ | 1 |
| Nakajima, A | 1 |
| Wada, K | 1 |
| Zhao, S | 1 |
| Terauchi, Y | 1 |
| Kadowaki, T | 1 |
| Aburatani, H | 1 |
| Matsuhashi, N | 1 |
| Nagai, R | 1 |
| Blumberg, RS | 1 |
| Takagi, T | 1 |
| Naito, Y | 1 |
| Tomatsuri, N | 1 |
| Handa, O | 1 |
| Ichikawa, H | 1 |
| Yoshida, N | 1 |
| Yoshikawa, T | 1 |
| Matsunaga, H | 1 |
| Hokari, R | 1 |
| Kurihara, C | 1 |
| Okada, Y | 1 |
| Takebayashi, K | 1 |
| Okudaira, K | 1 |
| Watanabe, C | 1 |
| Komoto, S | 1 |
| Nakamura, M | 1 |
| Tsuzuki, Y | 1 |
| Kawaguchi, A | 1 |
| Nagao, S | 1 |
| Itoh, K | 1 |
| Miura, S | 1 |
6 other studies available for pioglitazone and Colitis
| Article | Year |
|---|---|
Pioglitazone Attenuates Experimental Colitis-Associated Hyperalgesia through Improving the Intestinal Barrier Dysfunction.
Topics: Animals; Colitis; Hyperalgesia; Hypoglycemic Agents; Inflammation Mediators; Intestinal Mucosa; Male | 2020 |
Immunoregulatory mechanisms of macrophage PPAR-γ in mice with experimental inflammatory bowel disease.
Topics: Animals; Anti-Inflammatory Agents; Cells, Cultured; Colitis; Colon; Computational Biology; Dextran S | 2011 |
RETRACTED: Obesity-induced increase in tumor necrosis factor-α leads to development of colon cancer in mice.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Agents; Apoptosis; Azoxymethane; Blotting, Western; | 2012 |
Peroxisome proliferator-activated receptor gamma agonist ligands stimulate a Th2 cytokine response and prevent acute colitis.
Topics: Acute Disease; Animals; Antibody Formation; Antioxidants; Chromans; Colitis; Cytokines; Disease Mode | 2002 |
Pioglitazone, a PPAR-gamma ligand, provides protection from dextran sulfate sodium-induced colitis in mice in association with inhibition of the NF-kappaB-cytokine cascade.
Topics: Animals; Anticoagulants; Body Weight; Colitis; Colon; Dextran Sulfate; DNA; Female; Hypoglycemic Age | 2002 |
Omega-3 fatty acids exacerbate DSS-induced colitis through decreased adiponectin in colonic subepithelial myofibroblasts.
Topics: Adiponectin; Animals; Anti-Inflammatory Agents; Cells, Cultured; Colitis; Dextran Sulfate; Dietary F | 2008 |