Page last updated: 2024-11-02

pioglitazone and Chronic Lung Injury

pioglitazone has been researched along with Chronic Lung Injury in 5 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Research Excerpts

ExcerptRelevanceReference
"Since PPAR-γ agonists have been demonstrated to promote neonatal lung maturation and injury repair, we hypothesized that a formulation of a PPAR-γ agonist, pioglitazone (PGZ) and a synthetic lung surfactant (a surfactant protein B peptide mimic, B-YL) combined would stimulate lung maturation and block hyperoxia-induced neonatal lung injury more effectively than either modality alone."7.88A Combination of the Aerosolized PPAR-γ Agonist Pioglitazone and a Synthetic Surfactant Protein B Peptide Mimic Prevents Hyperoxia-Induced Neonatal Lung Injury in Rats. ( Lee, C; Rehan, VK; Sakurai, R; Shen, H; Walther, FJ; Waring, AJ, 2018)
"Hyperoxia-induced lung injury is characterized by acute alveolar injury, disrupted epithelial-mesenchymal signaling, oxidative stress, and surfactant dysfunction, yet currently, there is no effective treatment."5.91Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants. ( Chuang, TD; Kurihara, C; Rehan, VK; Sakurai, R; Walther, FJ; Waring, AJ, 2023)
"Since PPAR-γ agonists have been demonstrated to promote neonatal lung maturation and injury repair, we hypothesized that a formulation of a PPAR-γ agonist, pioglitazone (PGZ) and a synthetic lung surfactant (a surfactant protein B peptide mimic, B-YL) combined would stimulate lung maturation and block hyperoxia-induced neonatal lung injury more effectively than either modality alone."3.88A Combination of the Aerosolized PPAR-γ Agonist Pioglitazone and a Synthetic Surfactant Protein B Peptide Mimic Prevents Hyperoxia-Induced Neonatal Lung Injury in Rats. ( Lee, C; Rehan, VK; Sakurai, R; Shen, H; Walther, FJ; Waring, AJ, 2018)
"Hyperoxia-induced lung injury is characterized by acute alveolar injury, disrupted epithelial-mesenchymal signaling, oxidative stress, and surfactant dysfunction, yet currently, there is no effective treatment."1.91Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants. ( Chuang, TD; Kurihara, C; Rehan, VK; Sakurai, R; Walther, FJ; Waring, AJ, 2023)
"Carvacrol treatment improved inhaled PQ-induced lug injury similar to the effects of dexamethasone."1.62Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats. ( Amin, F; Boskabady, MH; Kazerani, HR; Memarzia, A; Rad, HK, 2021)
"Although pioglitazone-induced lung injury is very rare, clinicians should keep it in mind when pioglitazone is used."1.43Pioglitazone-induced Pulmonary Injury in a Very Elderly Patient. ( Fujihara, K; Isono, M; Kagohashi, K; Katayama, K; Kumagai, R; Ohara, G; Satoh, H; Yagyu, H, 2016)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's2 (40.00)2.80

Authors

AuthorsStudies
Kurihara, C1
Sakurai, R3
Chuang, TD1
Waring, AJ2
Walther, FJ2
Rehan, VK3
Amin, F1
Memarzia, A1
Rad, HK1
Kazerani, HR1
Boskabady, MH1
Lee, C1
Shen, H1
Morales, E1
Husain, S1
Paek, D1
Gong, M1
Ibe, B1
Li, Y1
Husain, M1
Torday, JS1
Katayama, K1
Kumagai, R1
Isono, M1
Fujihara, K1
Yagyu, H1
Ohara, G1
Kagohashi, K1
Satoh, H1

Other Studies

5 other studies available for pioglitazone and Chronic Lung Injury

ArticleYear
Combination of pioglitazone, a PPARγ agonist, and synthetic surfactant B-YL prevents hyperoxia-induced lung injury in adult mice lung explants.
    Pulmonary pharmacology & therapeutics, 2023, Volume: 80

    Topics: Animals; Hyperoxia; Lung; Lung Injury; Mice; Pioglitazone; PPAR gamma; PPAR-gamma Agonists; Surface-

2023
Carvacrol and PPARγ agonist, pioglitazone, affects inhaled paraquat-induced lung injury in rats.
    Scientific reports, 2021, 04-14, Volume: 11, Issue:1

    Topics: Animals; Case-Control Studies; Cymenes; Dexamethasone; Disease Models, Animal; Drug Synergism; Gene

2021
A Combination of the Aerosolized PPAR-γ Agonist Pioglitazone and a Synthetic Surfactant Protein B Peptide Mimic Prevents Hyperoxia-Induced Neonatal Lung Injury in Rats.
    Neonatology, 2018, Volume: 113, Issue:4

    Topics: Administration, Inhalation; Animals; Animals, Newborn; Biomimetic Materials; Cell Differentiation; F

2018
Nebulized PPARγ agonists: a novel approach to augment neonatal lung maturation and injury repair in rats.
    Pediatric research, 2014, Volume: 75, Issue:5

    Topics: Administration, Inhalation; Animals; Animals, Newborn; Bronchoalveolar Lavage; Cell Differentiation;

2014
Pioglitazone-induced Pulmonary Injury in a Very Elderly Patient.
    Internal medicine (Tokyo, Japan), 2016, Volume: 55, Issue:13

    Topics: Adrenal Cortex Hormones; Aged, 80 and over; Diabetes Mellitus, Type 2; Dyspnea; Female; Humans; Lung

2016