pioglitazone and Chromosomal Translocation studies

pioglitazone and Chromosomal Translocation

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Research Excerpts

Excerpt	Relevance	Reference
"Approximately 35% of follicular thyroid carcinomas harbor a chromosomal translocation that results in expression of a paired box gene 8-peroxisome proliferator-activated receptor γ gene (PPARγ) fusion protein (PPFP)."	1.37	Pioglitazone induces a proadipogenic antitumor response in mice with PAX8-PPARgamma fusion protein thyroid carcinoma. ( Colby, LA; Diallo-Krou, E; Dobson, ME; Giordano, TJ; Grachtchouk, V; Koenig, RJ; Wilkinson, JE; Yu, J, 2011)

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	2 (100.00)	24.3611
2020's	0 (0.00)	2.80

Timeframe

Studies, this research(%)

All Research%

pre-1990

0 (0.00)

18.7374

1990's

0 (0.00)

18.2507

2000's

0 (0.00)

29.6817

2010's

2 (100.00)

24.3611

2020's

0 (0.00)

2.80

Authors

Authors	Studies
Zhang, Y	1
Yu, J	2
Grachtchouk, V	2
Qin, T	1
Lumeng, CN	1
Sartor, MA	1
Koenig, RJ	2
Dobson, ME	1
Diallo-Krou, E	1
Colby, LA	1
Wilkinson, JE	1
Giordano, TJ	1

Studies

Zhang, Y

Yu, J

Grachtchouk, V

Qin, T

Lumeng, CN

Sartor, MA

Koenig, RJ

Dobson, ME

Diallo-Krou, E

Colby, LA

Wilkinson, JE

Giordano, TJ

Other Studies

2 other studies available for pioglitazone and Chromosomal Translocation

Article	Year
Genomic binding of PAX8-PPARG fusion protein regulates cancer-related pathways and alters the immune landscape of thyroid cancer. Oncotarget, 2017, Jan-24, Volume: 8, Issue:4 Topics: Adenocarcinoma, Follicular; Animals; Binding Sites; Chromatin Immunoprecipitation; Disease Models, A	2017
Pioglitazone induces a proadipogenic antitumor response in mice with PAX8-PPARgamma fusion protein thyroid carcinoma. Endocrinology, 2011, Volume: 152, Issue:11 Topics: Adenocarcinoma, Follicular; Adipogenesis; Animals; Mice; Mice, Transgenic; Oncogene Proteins, Fusion	2011

Article

Year

Genomic binding of PAX8-PPARG fusion protein regulates cancer-related pathways and alters the immune landscape of thyroid cancer.

Oncotarget, 2017, Jan-24, Volume: 8, Issue:4

Topics: Adenocarcinoma, Follicular; Animals; Binding Sites; Chromatin Immunoprecipitation; Disease Models, A

2017

Pioglitazone induces a proadipogenic antitumor response in mice with PAX8-PPARgamma fusion protein thyroid carcinoma.

Endocrinology, 2011, Volume: 152, Issue:11

Topics: Adenocarcinoma, Follicular; Adipogenesis; Animals; Mice; Mice, Transgenic; Oncogene Proteins, Fusion

2011