pioglitazone has been researched along with Chromosomal Translocation in 2 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Excerpt | Relevance | Reference |
---|---|---|
"Approximately 35% of follicular thyroid carcinomas harbor a chromosomal translocation that results in expression of a paired box gene 8-peroxisome proliferator-activated receptor γ gene (PPARγ) fusion protein (PPFP)." | 1.37 | Pioglitazone induces a proadipogenic antitumor response in mice with PAX8-PPARgamma fusion protein thyroid carcinoma. ( Colby, LA; Diallo-Krou, E; Dobson, ME; Giordano, TJ; Grachtchouk, V; Koenig, RJ; Wilkinson, JE; Yu, J, 2011) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 0 (0.00) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 2 (100.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Zhang, Y | 1 |
Yu, J | 2 |
Grachtchouk, V | 2 |
Qin, T | 1 |
Lumeng, CN | 1 |
Sartor, MA | 1 |
Koenig, RJ | 2 |
Dobson, ME | 1 |
Diallo-Krou, E | 1 |
Colby, LA | 1 |
Wilkinson, JE | 1 |
Giordano, TJ | 1 |
2 other studies available for pioglitazone and Chromosomal Translocation
Article | Year |
---|---|
Genomic binding of PAX8-PPARG fusion protein regulates cancer-related pathways and alters the immune landscape of thyroid cancer.
Topics: Adenocarcinoma, Follicular; Animals; Binding Sites; Chromatin Immunoprecipitation; Disease Models, A | 2017 |
Pioglitazone induces a proadipogenic antitumor response in mice with PAX8-PPARgamma fusion protein thyroid carcinoma.
Topics: Adenocarcinoma, Follicular; Adipogenesis; Animals; Mice; Mice, Transgenic; Oncogene Proteins, Fusion | 2011 |