pioglitazone has been researched along with Choline Deficiency in 4 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Choline Deficiency: A condition produced by a deficiency of CHOLINE in animals. Choline is known as a lipotropic agent because it has been shown to promote the transport of excess fat from the liver under certain conditions in laboratory animals. Combined deficiency of choline (included in the B vitamin complex) and all other methyl group donors causes liver cirrhosis in some animals. Unlike compounds normally considered as vitamins, choline does not serve as a cofactor in enzymatic reactions. (From Saunders Dictionary & Encyclopedia of Laboratory Medicine and Technology, 1984)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Non-alcoholic steatohepatitis (NASH) may progress to liver cirrhosis, and NASH patients with liver cirrhosis have a risk of development of hepatocellular carcinoma." | 5.32 | Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. ( Kawaguchi, K; Okita, K; Omori, K; Sakaida, I; Takami, T; Tsuchiya, M, 2004) |
| "Ipragliflozin is a selective sodium glucose cotransporter 2 (SGLT2) inhibitor that increases urinary glucose excretion by inhibiting renal glucose reabsorption and thereby causes a subsequent antihyperglycemic effect." | 1.42 | Ipragliflozin, an SGLT2 inhibitor, exhibits a prophylactic effect on hepatic steatosis and fibrosis induced by choline-deficient l-amino acid-defined diet in rats. ( Hayashizaki-Someya, Y; Koide, K; Kurosaki, E; Mitori, H; Takakura, S; Takasu, T; Yamazaki, S, 2015) |
| "Pioglitazone may allow the donor indications for liver transplantation to be expanded to include severe macrovesicular fatty livers." | 1.38 | Decreased Mrp2 transport in severe macrovesicular fatty liver grafts. ( Aihara, A; Arii, S; Ban, D; Irie, T; Kudo, A; Nakamura, N; Ochiai, T; Tanaka, S, 2012) |
| "Non-alcoholic steatohepatitis (NASH) may progress to liver cirrhosis, and NASH patients with liver cirrhosis have a risk of development of hepatocellular carcinoma." | 1.32 | Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. ( Kawaguchi, K; Okita, K; Omori, K; Sakaida, I; Takami, T; Tsuchiya, M, 2004) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hayashizaki-Someya, Y | 1 |
| Kurosaki, E | 1 |
| Takasu, T | 1 |
| Mitori, H | 1 |
| Yamazaki, S | 1 |
| Koide, K | 1 |
| Takakura, S | 1 |
| Da Silva Morais, A | 1 |
| Lebrun, V | 1 |
| Abarca-Quinones, J | 1 |
| Brichard, S | 1 |
| Hue, L | 1 |
| Guigas, B | 1 |
| Viollet, B | 1 |
| Leclercq, IA | 1 |
| Kudo, A | 1 |
| Ban, D | 1 |
| Aihara, A | 1 |
| Irie, T | 1 |
| Ochiai, T | 1 |
| Nakamura, N | 1 |
| Tanaka, S | 1 |
| Arii, S | 1 |
| Kawaguchi, K | 1 |
| Sakaida, I | 1 |
| Tsuchiya, M | 1 |
| Omori, K | 1 |
| Takami, T | 1 |
| Okita, K | 1 |
4 other studies available for pioglitazone and Choline Deficiency
| Article | Year |
|---|---|
Ipragliflozin, an SGLT2 inhibitor, exhibits a prophylactic effect on hepatic steatosis and fibrosis induced by choline-deficient l-amino acid-defined diet in rats.
Topics: Amino Acids; Animals; Choline Deficiency; Food, Formulated; Glucosides; Hydroxyproline; Hypoglycemic | 2015 |
Prevention of steatohepatitis by pioglitazone: implication of adiponectin-dependent inhibition of SREBP-1c and inflammation.
Topics: Adiponectin; AMP-Activated Protein Kinase Kinases; Animals; Choline Deficiency; DNA Primers; Fatty L | 2009 |
Decreased Mrp2 transport in severe macrovesicular fatty liver grafts.
Topics: Animals; ATP-Binding Cassette Transporters; Bile; Choline Deficiency; Cyclic AMP-Dependent Protein K | 2012 |
Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet.
Topics: Amino Acids; Animal Feed; Animals; Biomarkers; Body Weight; Choline Deficiency; Fatty Liver; Fibrosi | 2004 |