pioglitazone has been researched along with Cholestasis in 3 studies
Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.
Cholestasis: Impairment of bile flow due to obstruction in small bile ducts (INTRAHEPATIC CHOLESTASIS) or obstruction in large bile ducts (EXTRAHEPATIC CHOLESTASIS).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Pretreatment with pioglitazone dose-dependently attenuated gastric lesions induced by ethanol in both sham and cholestatic rats, but this effect was more prominent in cholestatic ones." | 1.40 | The increased gastroprotective effect of pioglitazone in cholestatic rats: role of nitric oxide and tumour necrosis factor alpha. ( Amirghofran, Z; Dehpour, AR; Janahmadi, Z; Moezi, L; Nekooeian, AA, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Dawson, S | 1 |
| Stahl, S | 1 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 1 |
| Moezi, L | 1 |
| Janahmadi, Z | 1 |
| Amirghofran, Z | 1 |
| Nekooeian, AA | 1 |
| Dehpour, AR | 1 |
| Pinto, AG | 1 |
| Cummings, OW | 1 |
| Chalasani, N | 1 |
3 other studies available for pioglitazone and Cholestasis
| Article | Year |
|---|---|
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
The increased gastroprotective effect of pioglitazone in cholestatic rats: role of nitric oxide and tumour necrosis factor alpha.
Topics: Animals; Cholestasis; Disease Models, Animal; Dose-Response Relationship, Drug; Ethanol; Interleukin | 2014 |
Severe but reversible cholestatic liver injury after pioglitazone therapy.
Topics: Cholestasis; Diabetes Mellitus, Type 2; Female; Humans; Hypoglycemic Agents; Middle Aged; Pioglitazo | 2002 |