Page last updated: 2024-11-02

pioglitazone and Cerebral Infarction

pioglitazone has been researched along with Cerebral Infarction in 10 studies

Pioglitazone: A thiazolidinedione and PPAR GAMMA agonist that is used in the treatment of TYPE 2 DIABETES MELLITUS.
pioglitazone : A member of the class of thiazolidenediones that is 1,3-thiazolidine-2,4-dione substituted by a benzyl group at position 5 which in turn is substituted by a 2-(5-ethylpyridin-2-yl)ethoxy group at position 4 of the phenyl ring. It exhibits hypoglycemic activity.

Cerebral Infarction: The formation of an area of NECROSIS in the CEREBRUM caused by an insufficiency of arterial or venous blood flow. Infarcts of the cerebrum are generally classified by hemisphere (i.e., left vs. right), lobe (e.g., frontal lobe infarction), arterial distribution (e.g., INFARCTION, ANTERIOR CEREBRAL ARTERY), and etiology (e.g., embolic infarction).

Research Excerpts

ExcerptRelevanceReference
"Present study was carried out to investigate the possible neuroprotective effect of pioglitazone, an antidiabetic agent, peroxisome proliferator-activated receptor gamma (PPARgamma) agonist on acute phase changes in mice model of cerebral ischemia induced by Bilateral Common Carotid artery Occlusion (BCCAO)."7.76Neuroprotective effect of pioglitazone on acute phase changes induced by partial global cerebral ischemia in mice. ( Aggarwal, R; Chakrabarti, A; Medhi, B, 2010)
"The role of the phosphorylated signal transducer and activator of transcription-3 (p-STAT3) after cerebral ischemia by the peroxisome proliferator-activated receptor γ (PPARγ) agonist pioglitazone (PGZ) remains controversial."3.78Activation of signal transducer and activator of transcription-3 by a peroxisome proliferator-activated receptor gamma agonist contributes to neuroprotection in the peri-infarct region after ischemia in oophorectomized rats. ( Kageji, T; Kinouchi, T; Kitazato, KT; Matsushita, N; Nagahiro, S; Satomi, J; Shimada, K; Sumiyoshi, M; Tada, Y; Yagi, K, 2012)
"Present study was carried out to investigate the possible neuroprotective effect of pioglitazone, an antidiabetic agent, peroxisome proliferator-activated receptor gamma (PPARgamma) agonist on acute phase changes in mice model of cerebral ischemia induced by Bilateral Common Carotid artery Occlusion (BCCAO)."3.76Neuroprotective effect of pioglitazone on acute phase changes induced by partial global cerebral ischemia in mice. ( Aggarwal, R; Chakrabarti, A; Medhi, B, 2010)
"Pre-treatment with fenofibrate and pioglitazone in addition to their combination improved neurobehavioral dysfunction, reduced cerebral infarct volume, attenuated inflammatory and apoptotic markers and ameliorated histopathological changes in I/R injured rats."1.56The impact of single and combined PPAR-α and PPAR-γ activation on the neurological outcomes following cerebral ischemia reperfusion. ( Abdelrehim, AB; Ahmed, AF; Heeba, GH; Shehata, AHF, 2020)
"Pioglitazone or vehicle was infused intracerebroventricularly over a 5-day period before, during and 24 or 48 h after middle cerebral artery occlusion."1.36Peroxisome-proliferator-activated receptors gamma and peroxisome-proliferator-activated receptors beta/delta and the regulation of interleukin 1 receptor antagonist expression by pioglitazone in ischaemic brain. ( Culman, J; Glatz, T; Gohlke, P; Herdegen, T; Nguyen-Ngoc, M; Stöck, I; Zhao, Y, 2010)
"Pioglitazone treatment reduced the infarct size and improved neurological functions."1.35Peroxisome proliferator-activated receptorsgamma (PPARgamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia. ( Culman, J; Gohlke, P; Herdegen, T; Patzer, A; Stöck, I; Zhao, Y, 2008)
"Rosiglitazone treatment curtailed the post-ischemic expression of the pro-inflammatory genes interleukin-1beta, interleukin-6, macrophage inflammatory protein-1alpha, monocyte chemoattractant protein-1, cyclooxygenase-2, inducible nitric oxide synthase, early growth response-1, CCAAT/enhancer binding protein-beta and nuclear factor-kappa B, and increased the expression of the anti-oxidant enzymes catalase and copper/zinc-superoxide dismutase."1.34Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents. ( Bowen, KK; Feinstein, DL; Kapadia, R; Liang, J; Satriotomo, I; Tureyen, K; Vemuganti, R, 2007)
"Pioglitazone or vehicle were i."1.33The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain. ( Culman, J; Gohlke, P; Herdegen, T; Patzer, A; Zhao, Y, 2005)

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (50.00)29.6817
2010's4 (40.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Shehata, AHF1
Ahmed, AF1
Abdelrehim, AB1
Heeba, GH1
Patzer, A2
Zhao, Y3
Stöck, I2
Gohlke, P3
Herdegen, T3
Culman, J3
Lee, SR1
Kim, HY1
Hong, JS1
Baek, WK1
Park, JW1
Glatz, T1
Nguyen-Ngoc, M1
Medhi, B1
Aggarwal, R1
Chakrabarti, A1
Blankenship, D1
Niemi, J1
Hilow, E1
Karl, M1
Sundararajan, S1
Kinouchi, T1
Kitazato, KT1
Shimada, K1
Yagi, K1
Tada, Y1
Matsushita, N1
Sumiyoshi, M1
Satomi, J1
Kageji, T1
Nagahiro, S1
Tureyen, K1
Kapadia, R1
Bowen, KK1
Satriotomo, I1
Liang, J1
Feinstein, DL1
Vemuganti, R1

Other Studies

10 other studies available for pioglitazone and Cerebral Infarction

ArticleYear
The impact of single and combined PPAR-α and PPAR-γ activation on the neurological outcomes following cerebral ischemia reperfusion.
    Life sciences, 2020, Jul-01, Volume: 252

    Topics: Animals; Apoptosis; Brain; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Drug Therapy

2020
Peroxisome proliferator-activated receptorsgamma (PPARgamma) differently modulate the interleukin-6 expression in the peri-infarct cortical tissue in the acute and delayed phases of cerebral ischaemia.
    The European journal of neuroscience, 2008, Volume: 28, Issue:9

    Topics: Animals; Anti-Inflammatory Agents; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Ence

2008
PPARgamma agonist pioglitazone reduces matrix metalloproteinase-9 activity and neuronal damage after focal cerebral ischemia.
    Biochemical and biophysical research communications, 2009, Feb-27, Volume: 380, Issue:1

    Topics: Animals; Brain Ischemia; Cerebral Infarction; Cytoprotection; Male; Matrix Metalloproteinase Inhibit

2009
Peroxisome-proliferator-activated receptors gamma and peroxisome-proliferator-activated receptors beta/delta and the regulation of interleukin 1 receptor antagonist expression by pioglitazone in ischaemic brain.
    Journal of hypertension, 2010, Volume: 28, Issue:7

    Topics: Animals; Brain; Brain Ischemia; Cerebral Infarction; Infarction, Middle Cerebral Artery; Interleukin

2010
Neuroprotective effect of pioglitazone on acute phase changes induced by partial global cerebral ischemia in mice.
    Indian journal of experimental biology, 2010, Volume: 48, Issue:8

    Topics: Acute-Phase Reaction; Animals; Antioxidants; Brain Edema; Brain Ischemia; Carotid Artery, Common; Ce

2010
Oral pioglitazone reduces infarction volume and improves neurologic function following MCAO in rats.
    Advances in experimental medicine and biology, 2011, Volume: 701

    Topics: Administration, Oral; Animals; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Hypoglyc

2011
Activation of signal transducer and activator of transcription-3 by a peroxisome proliferator-activated receptor gamma agonist contributes to neuroprotection in the peri-infarct region after ischemia in oophorectomized rats.
    Stroke, 2012, Volume: 43, Issue:2

    Topics: Animals; Apoptosis; Basal Ganglia; Brain; Brain Ischemia; Caspase 3; Cell Nucleus; Cerebral Infarcti

2012
The intracerebral application of the PPARgamma-ligand pioglitazone confers neuroprotection against focal ischaemia in the rat brain.
    The European journal of neuroscience, 2005, Volume: 22, Issue:1

    Topics: Animals; Brain; Brain Edema; Brain Ischemia; Cerebral Infarction; Disease Models, Animal; Encephalit

2005
[New subgroup analysis of the PROactive Study. Risk for recurrent stroke cut in half].
    MMW Fortschritte der Medizin, 2006, Oct-12, Volume: 148, Issue:41

    Topics: Cerebral Infarction; Clinical Trials as Topic; Diabetes Mellitus, Type 2; Diabetic Angiopathies; Hum

2006
Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents.
    Journal of neurochemistry, 2007, Volume: 101, Issue:1

    Topics: Anilides; Animals; Cerebral Infarction; Chemotaxis, Leukocyte; Cytokines; Diabetes Mellitus, Type 2;

2007